Search results for " Renal cell carcinoma"
showing 9 items of 59 documents
Efecto de la radiación ionizante persistente a bajas dosis en la angiogénesis del carcinoma renal de células claras : estudio morfométrico comparativ…
2013
La angiogénesis en el carcinoma de células renales claras (ccRCC) es un proceso influenciado por sustancias producidas en su mayoría por el tumor en respuesta a una reestructuración vascular necesaria en su etapa de crecimiento y metástasis. La exposición persistente a bajas dosis de radiación ionizante (CPLDIR) ha sido asociada a modificaciones nucleares que estimulan la proliferación celular neoplásica. Sus efectos en el proceso de neovascularización de los ccRCC han sido poco estudiados. Métodos: Estudiamos a través de un estudio morfométrico semiautomático e inmunohistoquímico, la densidad microvascular (MVD) y la expresión de factores angiogénicos en 124 pacientes con ccRCC de regiones…
VHL gēna mutācijas gaišo šūnu nieru karcinomas gadījumā
2019
Nieru šūnu karcinoma ir sestais biežāk diagnosticētais audzējs no visām onkoloģiskajām diagnozēm pasaulē. Gaišo šūnu nieru karcinoma ir 65-70% no visiem saslimšanas gadījumiem ar nieru audzējiem. Izmaiņas von Hippel-Lindau (VHL) gēnā, kurš ir visbiežāk mutētais gēns gaišo šūnu nieru karcinomas gadījumā, tiek salīdzinātas starp in vitro audzētām cilvēku nieru proksimālo kanāliņu epitēlija šūnām un gaišo šūnu nieru karcinomas šūnu līnijām un primārajām šunām, kuras iegūtas no gaišo šūnu nieru karcinomas pacientu audiem un blakus esošiem veselajiem audiem. Darba rezultātā tika konstatēts viena nukleotīda polimorfisms pacientu gaišo šūnu nieru karcinomas audos un veselajos audos no VHL gēna izo…
Prediction of significant renal function decline after open, laparoscopic, and robotic partial nephrectomy: External validation of the Martini’s nomo…
2022
Objectives: Martini et al. developed a nomogram to predict significant (>25%) renal function loss after robot-assisted partial nephrectomy and identified four risk categories. We aimed to externally validate Martini’s nomogram on a large, national, multi-institutional data set including open, laparoscopic, and robot-assisted partial nephrectomy. Methods: Data of 2584 patients treated with partial nephrectomy for renal masses at 26 urological Italian centers (RECORD2 project) were collected. Renal function was assessed at baseline, on third postoperative day, and then at 6, 12, 24, and 48 months postoperatively. Multivariable models accounting for variables included in the Martini’s nomog…
Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent manner. Being a pattern recognition molecule of the innate immunity, C1q can recognize a number of self, non-self and altered-self ligands and bring about effector mechanisms designed to clear pathogens via opsonisation and inflammatory response. C1q is locally synthesized by macrophages and dendritic cells, and thus, can get involved in a range of biological processes, such as angiogenesis and tissue remodeling, immune modulation, and immu…
CT and MR imaging of cystic renal lesions
2020
AbstractCystic renal lesions are a common incidental finding on routinely imaging examinations. Although a benign simple cyst is usually easy to recognize, the same is not true for complex and multifocal cystic renal lesions, whose differential diagnosis includes both neoplastic and non-neoplastic conditions. In this review, we will show a series of cases in order to provide tips to identify benign cysts and differentiate them from malignant ones.
Transperitoneal vs retroperitoneal minimally invasive partial nephrectomy: comparison of perioperative outcomes and functional follow-up in a large m…
2020
Abstract Background Aim of this study was to evaluate and compare perioperative outcomes of transperitoneal (TP) and retroperitoneal (TR) approaches in a multi-institutional cohort of minimally invasive partial nephrectomy (MI-PN). Material and methods All consecutive patients undergone MI-PN for clinical T1 renal tumors at 26 Italian centers (RECORd2 project) between 01/2013 and 12/2016 were evaluated, collecting the pre-, intra-, and postoperative data. The patients were then stratified according to the surgical approach, TP or RP. A 1:1 propensity score (PS) matching was performed to obtain homogeneous cohorts, considering the age, gender, baseline eGFR, surgical indication, clinical dia…
Chromophobe Renal Cell Carcinoma
1996
SUMMARY A case ofchromophobe renal cell carcinoma is reported in a 73 year-old man. Light microscopically, the tumor was composed of polygonal cells with a slightly eosinophilic and a fine reticular pattern, and a reaction of the cytoplasm with Hale's acid iron colloid. Ultrastructural analysis showed membranous microuesicles within the tumor cells, with degenerated mitochondria. Immunohistochemical profile against intermediate filaments was positive to cytokeratin 18 and negative against uimentin. Flow cytometry and cytogenetics revealed a predominant bypertriploid population. Few cases have been published with flow cytometry and cytogenetic findings. We report a new case.
Unusual giant chromophobe renal cancer totally managed with laparoscopic technique: Report of a case
2020
Highlights • We describe a case report of giant renal cell chromophobe carcinoma totally treated by laparoscopic surgery. • The size of renal lesion represents a critical point in surgical approach because to perform a laparoscopic radical nephrectomy can be challenging even for skilled surgeons in giant renal tumors. • A brief review of literature was performed to identify outcomes and potentially surgical advantages of laparoscopic approach for retroperitoenal liposarcoma. • The possibility of the laparoscopic approach derives from from the preoperative identification of adipose cleavage, from the absence of invasion of major vascular axes, from the absence of distant metastatic lesions.
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
2021
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…