Search results for " Research Design"
showing 10 items of 95 documents
Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: A European consensus position paper
2015
While they account for one-fifth of new cancer cases, rare cancers are difficult to study. A higher than average degree of uncertainty should be accommodated for clinical as well as for population-based decision making. Rules of rational decision making in conditions of uncertainty should be rigorously followed and would need widely informative clinical trials. In principle, any piece of new evidence would need to be exploited in rare cancers. Methodologies to explicitly weigh and combine all the available evidence should be refined, and the Bayesian logic can be instrumental to this end. Likewise, Bayesian-design trials may help optimize the low number of patients liable to be enrolled in …
Writing to Learn Programming? : A Single Case Pilot Study
2016
This paper explores the use of writing-to-learn techniques in the context of programming education. It presents a pilot study where a writing assignment is introduced with the purpose of strengthening students' conceptual understanding of a programming construct. The intervention is evaluated using a single case research design, which is augmented by qualitative interview data. Students participating in the study were mildly positive towards the intervention and the results encourage more work on the topic. This work sets directions for further investigations into how writing-to-learn can strengthen programming education and contributes with insights into what kinds of results can be obtain…
The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes
2015
Background. Critically ill patients appear to be at high risk of developing deep vein thrombosis (DVT) and pulmonary embolism during their stay in the intensive care unit (ICU). However, little is known about the clinical course of venous thromboembolism in the ICU setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of DVT on hospital and ICU stay, duration of mechanical ventilation and mortality in critically ill patients. We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the ICU setting. Materials and methods. MEDLINE and EMBASE databases were searched up…
Revista electrónica de investigación y evaluación educativa
2014
Resumen basado en el de la publicación Título, resumen y palabras clave en inglés y español Se analiza el estatus del género existente en los equipos o consejos editoriales de las revistas científicas españolas de Educación. A priori, se indaga el estatus de la eminencia científica en el campo de la Educación; con el fin de detectar los posibles sesgos de género. Como análisis complementario se considera la nacionalidad o procedencia de los miembros de los consejos editoriales de las revistas de Educación. El hallazgo principal testimonia un fuerte sesgo contra las mujeres cuando éstas son consideradas editoras. Valencia ESP
Metodologia della ricerca sociale e politiche pubbliche
2020
In questo capitolo si passano in rasegna i principali concetti che devono essere padroneggiati dal buon valutatore delle politiche pubbliche e gli strumenti che devono far parte della sua cassetta degli attrezzi. Trattando la causazione e l'esperimento vedremo come nel campo delle scienze sociali sia necessario avvalersi di alcuni accorgimenti per disegnare una buona ricerca valutativa. In this chapter we review the main concepts that must be mastered by the good public policy evaluator and the tools that must be part of his toolbox. In dealing with causation and experiment we will see how in the field of social sciences it is necessary to use some precautions to design good evaluative rese…
Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) …
2017
Background HCV GT4 accounts for up to 20% of HCV infections worldwide. Simeprevir, given for 12 weeks as part of a 24- or 48-week combination regimen with PR is approved for the treatment of chronic HCV GT4 infection. Primary study objectives were assessment of efficacy and safety of simeprevir plus PR in treatment-naïve patients with HCV GT4 treated for 12 weeks. Primary efficacy outcome was sustained virologic response 12 weeks post-treatment (SVR12). Additional objectives included investigation of potential associations of rapid virologic response and baseline factors with SVR12. Methods This multicentre, open-label, single-arm study (NCT01846832) evaluated efficacy and safety of simepre…
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
2011
BACKGROUND: Tight-junction (TJ) protein degradation is a decisive step in hypoxic blood-brain barrier (BBB) breakdown in stroke. In this study we elucidated the impact of acute cerebral ischemia on TJ protein arrangement and the role of the apoptotic effector protease caspase-3 in this context. METHODOLOGY/PRINCIPAL FINDINGS: We used an in vitro model of the neurovascular unit and the guinea pig whole brain preparation to analyze with immunohistochemical methods the BBB properties and neurovascular integrity. In both methodological approaches we observed rapid TJ protein disruptions after 30 min of oxygen and glucose deprivation or middle cerebral artery occlusion, which were accompanied by…
Learning research in a laboratory classroom : a reflection on complementarity and commensurability among multiple analytical accounts
2022
With the myriad theories generated through research over the years, a continuing challenge for researchers is to navigate the multitude of theories in order to communicate their research, integrate empirical results, and make progress as a field by building upon empirical research. The Social Unit of Learning project was purposefully designed so that researchers from multiple disciplines with different theoretical perspectives could work together to examine the complexity of the mathematics classroom. In this paper, we reflect on the multiple analytical accounts generated from the project, drawing from the notions of complementarity and commensurability. Two parallel analyses, applying the …
Effectiveness of Organizational Interventions to Reduce Emergency Department Utilization: A Systematic Review
2012
BackgroundEmergency department (ED) utilization has dramatically increased in developed countries over the last twenty years. Because it has been associated with adverse outcomes, increased costs, and an overload on the hospital organization, several policies have tried to curb this growing trend. The aim of this study is to systematically review the effectiveness of organizational interventions designed to reduce ED utilization.Methodology/principal findingsWe conducted electronic searches using free text and Medical Subject Headings on PubMed and The Cochrane Library to identify studies of ED visits, re-visits and mortality. We performed complementary searches of grey literature, manual s…