Search results for " Resolution"

Calix[4]arene-Based Bis[2]catenanes: Synthesis and Chiral Resolution

2007

The exclusive formation of hydrogen-bonded dimers between tetraaryl and tetratosylurea calix[4]arenes has been used to prepare a series of ten "bisloop" tetraurea calix[4]arenes 3, in which adjacent phenylurea groups are covalently linked through alpha,omega-dioxyalkane chains. This dimerization with tetratosylurea 2 as template preorganizes the alkenyl residues of tetra(m-alkenyloxyphenyl) ureas 1 and enables their selective connection in high yield (up to 95 %) by olefin metathesis followed by hydrogenation. The "bisloop" calixarenes 3 also exclusively form heterodimers with 1. Thus, in a separated metathesis/hydrogenation sequence, a series of 14 cyclic bis[2]catenanes 4, in which two ca…

Determining the Geometry of Hydrogen Bonds in Solids with Picometer Accuracy by Quantum-Chemical Calculations and NMR Spectroscopy

2005

The structure of multiply hydrogen-bonded systems is determined with picometer accuracy by a combined solid-state NMR and quantum-chemical approach. On the experimental side, advanced 1H-15N dipolar recoupling NMR techniques are capable of providing proton-nitrogen distances of up to about 250 pm with an accuracy level of +/-1 pm for short distances (i.e., around 100 pm) and +/-5 pm for longer ones (i.e., 180 to 250 pm). The experiments were performed under fast magic-angle spinning, which ensures sufficient dipolar decoupling and spectral resolution of the 1H resonance lines. On the quantum-chemical side, the structures of the hydrogen-bonded systems were computationally optimised, yieldin…

Electron microscopy of gold nanoparticles at atomic resolution

2014

Detailed structure of a gold nanoparticle Adding only a few atoms or changing the capping ligand can dramatically change the structure of individual metal nanoparticles. Azubel et al. used aberration-corrected transmission electron microscopy to derive a three-dimensional reconstruction of water-soluble gold nanoparticles. Small-angle x-ray scattering and other techniques have also corroborated this model. They used this to determine the atomic structure, which compared favorably with density functional theory calculations, without assuming any a priori structural knowledge or the use of model fitting. Science , this issue p. 909

Combining Pharmacokinetics and Vibrational Spectroscopy: MCR-ALS Hard-and-Soft Modelling of Drug Uptake In Vitro Using Tailored Kinetic Constraints

2022

Raman microspectroscopy is a label-free technique which is very suited for the investigation of pharmacokinetics of cellular uptake, mechanisms of interaction, and efficacies of drugs in vitro. However, the complexity of the spectra makes the identification of spectral patterns associated with the drug and subsequent cellular responses difficult. Indeed, multivariate methods that relate spectral features to the inoculation time do not normally take into account the kinetics involved, and important theoretical information which could assist in the elucidation of the relevant spectral signatures is excluded. Here, we propose the integration of kinetic equations in the modelling of drug uptake…

Measurement and Analysis of the Raman Intensities of 12CD4

1995

0022-2852; The stimulated Raman spectrum of 12CD4 was recorded at high resolution, in the spectral range 1963 to 2260 cm(-1). Intensities of the rovibrational transitions were estimated by fitting the line profiles. The recorded elementary spectrum was 1 cm(-1) wide; all recordings were then intensity calibrated. Afterward, the relative Raman intensities were analyzed by using a polarizability model developed previously [A. Boutahar and M. Loete, Can. J. Phys. 69, 26-35 (1991); J. P. Champion, M. Loete, and G. Pierre, in ''Spectroscopy of the Earth's Atmosphere and Interstellar Molecules'' (K. Narahari Rao and A. Weber, Eds.), pp. 388-397, Academic Press, Boston. 1992]. The investigated reg…

The SMAP and Copernicus Sentinel 1A/B microwave active-passive high resolution surface soil moisture product

2019

Abstract Soil Moisture Active Passive (SMAP) mission of NASA was launched in January 2015. Currently, SMAP has an L-band radiometer and a defunct L-band radar with a rotating 6-m mesh reflector antenna. On July 7th, 2015, the SMAP radar malfunctioned and became inoperable. Consequently, the production of high-resolution active-passive soil moisture product got hampered, and only ~2.5 months (April 15th, 2015 to July 7th, 2015) of data remain available. Therefore, during the SMAP post-radar phase, many ways were examined to restart the high-resolution soil moisture product generation of the SMAP mission. One of the feasible approaches was to substitute the SMAP radar with other available SAR…

The effects of precipitates on CdZnTe device performance

2005

A high-intensity X-ray beam collimated down to a 10-micrometer spot size, available at Brookhaven's National Synchrotron Light Source (NSLS), was employed to perform X-ray mapping to measure the correlation between microscopic defects (precipitates) and variations in the collected charges in long-drift CdZnTe (CZT) detectors. First, we use X-ray diffraction topography (XDT) measurements at the high-energy beamline and IR microscopy to identify the defects distribution and strains in the bulk of CZT crystals. Then, we perform X-ray raster scans of the CZT detectors to measure their responses with 10-micrometer spatial resolution. The brightness of the source allows for good statistics in ver…

2014

Due to its millisecond-scale temporal resolution, EEG allows to assess neural correlates with precisely defined temporal relationship relative to a given event. This knowledge is generally lacking in data from functional magnetic resonance imaging (fMRI) which has a temporal resolution on the scale of seconds so that possibilities to combine the two modalities are sought. Previous applications combining event-related potentials (ERPs) with simultaneous fMRI BOLD generally aimed at measuring known ERP components in single trials and correlate the resulting time series with the fMRI BOLD signal. While it is a valuable first step, this procedure cannot guarantee that variability of the chosen …

Affine compensation of illumination in hyperspectral remote sensing images

2009

A problem when working with optical satellite or airborne images is the need to compensate for changes in the illumination conditions at the time of acquisition. This is particularly critical when working with time series of data. Atmospheric correction strategies based on radiative transfer codes may provide a rigorous solution but it may not be the best solution for situations where a huge amount of hyperspectral images may need to be processed and computational time is a critical factor. The GMES (”Global Monitoring for Environment and Security”) initiative has promoted the creation of a new generation of satellites (the SENTINEL series) with ”ultra-high resolution” and ”superspectral im…

Ein Auswerteprogramm zur quantitativen Untersuchung der Lungenventilation mittels dynamischer MRT von hochpolarisiertem 3He

2004

Purpose: 3 He-MRI is able to visualize the regional distribution of lung ventilation with a temporal and spatial resolution so far unmatched by any other technique. The aim of the study was the development of a new software tool for quantification of dynamic ventilation parameters in absolute physical units. Materials and Methods: During continuous breathing, a bolus of hyperpolarized 3 He (300 ml) was applied at inspiration and a series of 168 coronal projection images simultaneously acquired using a 2D FLASH-sequence. Postprocessing software was developed to analyze the 3 He distribution in the lung. After correction for lung motion, several ventilation parameters (rise time, delay time, …