Search results for " SCR."
showing 10 items of 1323 documents
Immigration and changes in the epidemiology of hemoglobin disorders in Italy : an emerging public health burden
2012
Abstract Background In the last years Italy is confronting with massive migratory movements from developing countries where hemoglobinopathies are widespread. This is causing a large diffusion and a changing spectrum in the epidemiology of hemoglobin disorders in Italy. Methods Investigations recently published in Italy on hemoglobinopathies among immigrants were revised in order to appreciate the impact of immigration from developing countries on epidemiology of these pathologies and to outline adequate guidelines of prevention. Results Although in Italy there is a limited number of investigations regarding the relation between immigration and hemoglobin disorders, published data show that…
Pap Testing in a High-Income Country with Suboptimal Compliance Levels: A Survey on Acceptance Factors among Sicilian Women
2018
Cervical cancer screening is uncommon, especially in low-income countries and among lower socioeconomic status people in high-income countries. The aims of this study were to examine the adherence of Sicilian women to Pap testing and to identify the determinants of this in a population with a secondary prevention attitude lower than high-income countries and the national average. A cross-sectional study called &ldquo
Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score
2021
The British journal of surgery 108(11), 1274-1292 (2021). doi:10.1093/bjs/znab183
Syntactic complexity in Finnish-background EFL learners’ writing at CEFR levels A1–B2
2022
Eurooppalaisen viitekehyksen (EVK) merkitys kielikoulutukselle on lisännyt tutkimusta sen taitotasojen kielellisistä piirteistä; tarkempi tieto näistä piirteistä auttaisi EVK:n soveltamista opetusmateriaalien, kurssien ja arviointin laatimiseen. Tutkimuksessa selvitettiin eroavatko EVK:n tasot toisistaan syntaksin kompleksisuuden perusteella. Suomalaiset 14- ja 17-vuotiaat englannin oppijat (N=379) kirjoittivat kolme kirjoitelmaa, jotka arvioitiin EVK:n taitotasoille. Arviointiaineisto tutkittiin monitahoisella Rasch-analyysillä ja tekstien piirteet selvitettiin automaattisilla analyysiohjelmilla. Tuloksien perusteella alimpia EVK-tasoja (A1–A2) erotti selvimmin toisistaan lauseiden ja T-yk…
Polish highlander jokes and their targets
2017
The aim of the paper is to identify the characteristic features of jokes about Polish highlanders and analyse them to isolate the comic script of a highlander. This group of jokes is treated as a good illustration of Christie Davies’s ethnic jokes theory concerning canny versus stupid and centre versus periphery oppositions, as well as mind over matter. A particular type of reasoning and the use of regional dialect are distinctive features of the joke targets that make it possible to perceive these jokes as a culturally specific phenomenon. The head shepherd (called baca) is the key character of the cycle. He is a very down-to-earth person, who is proud of his practical wisdom and has a ver…
Bioactive Constituents of Juniperus turbinata Guss. from La Maddalena Archipelago.
2018
A comprehensive phytochemical study of Juniperus turbinata (Cupressaceae) collected from La Maddalena Archipelago (Sardinia, Italy) is reported. Both the essential oil and the ethanolic extract obtained from the aerial parts were analyzed. The essential oil appears to belong to a new chemotype compared to other Mediterranean juniper accessions, as it was favored by geographic isolation of the isles. It showed a low content of monoterpene hydrocarbons and -terpineol, ent-manoyl oxide, 1,10-di-epi-cubenol as the major constituents. The ethanolic fraction contained mainly diterpenoids. Among these, 15-formyloxyimbricatolic acid (7) is a new natural product since it has hitherto been obtained o…
Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice
2013
In the present work biocompatible quercetin and curcumin nanovesicles were developed as a novel approach to prevent and restore skin tissue defects on chronic cutaneous pathologies. Stable and suitable quercetin- and curcumin-loaded phospholipid vesicles, namely liposomes and penetration enhancer-containing vesicles (PEVs), were prepared. Vesicles were made from a highly biocompatible mixture of phospholipids and alternatively a natural polyphenol, quercetin or curcumin. Liposomes were obtained by adding water, while PEVs by adding polyethylene glycol 400 and Oramix®CG110 to the water phase. Transmission electron microscopy, cryogenic-transmission electron microscopy and small- and wide-ang…
Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.
2011
Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…
Meeting the Challenges of Generational Change in the Teaching Profession : Towards a European Model for Intergenerational Teacher Collaboration
2013
In a European-wide effort to improve the professional development of teachers, the 2AgePro project was conducted from November 2008 to October 2010. One of its goals was to develop and test different forms of intergenerational teacher collaboration among junior and senior teachers in primary and secondary schools. Another aim was to utilise the results from these pilots, which were conducted in the Czech Republic, Finland, Germany, the Netherlands, and Sweden, to create a model for intergenerational collaboration that could be used in any national or cultural setting. This article reports on the national pilots and proposes a European model for intergenerational collaboration for teachers. …
TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro
2017
International audience; The quest for chemicals able to operate at selected genomic loci in a spatiotemporally controlled manner is desirable to create manageable DNA damages. Mounting evidence now shows that alternative DNA structures, including G-quadruplexes and branched DNA (or DNA junctions), might hamper proper progression of replication fork, thus triggering DNA damages and genomic instability. Therefore, small molecules that stabilize these DNA structures are currently scrutinized as a promising way to create genomic defects that cannot be dealt with properly by cancer cells. While much emphasis has been recently given to G-quadruplexes and related ligands, we report herein on three…