Search results for " STRESS"

Transcriptional Rewiring, Adaptation, and the Role of Gene Duplication in the Metabolism of Ethanol of Saccharomyces cerevisiae

2020

Ethanol is the main by-product of yeast sugar fermentation that affects microbial growth parameters, being considered a dual molecule, a nutrient and a stressor. Previous works demonstrated that the budding yeast arose after an ancient hybridization process resulted in a tier of duplicated genes within its genome, many of them with implications in this ethanol “produce-accumulate-consume” strategy. The evolutionary link between ethanol production, consumption, and tolerance versus ploidy and stability of the hybrids is an ongoing debatable issue. The implication of ancestral duplicates in this metabolic rewiring, and how these duplicates differ transcriptionally, remains unsolved. Here, we …

Rauga Kluyveromyces marxianus acetāta tolerance

2017

Maģistra darba mērķis bija novērtēt rauga Kluyveromyces marxianus iespējamos šūnu adaptācijas mehānismus pret acetāta izraisīto stresu. Fermentācijās ar laktozi saturošu substrātu un pievienotu 40 mM acetātu šūnu kultūrai tika novērota paildzināta lag fāze, kuras laikā palielinājās šūnu populācijas rezistence pret acetātu. Pētījumos tika novērota rauga Kluyveromyces marxianus DSM 5422 šūnu populācijas heterogenitāte, kas liecina, ka daļa no šūnām sākotnēji ir tolerantāka pret organisko skābju izraisīto stresu. Kultivējot raugu K. marxianus laktozi saturošā barotnē ar pievienotu acetātu, tika novērota iekššūnu vides pH palielināšanās. Iespējams, raugam K. marxianus vājo skābju izraisīta stre…

“Stress e iperattività dell’asse ipotalamo-ipofisi-surrene nella patogenesi dei disturbi psicotici”

2014

Glial Chloride Homeostasis Under Transient Ischemic Stress

2021

High water permeabilities permit rapid adjustments of glial volume upon changes in external and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–]int) and glial cell swelling are often assumed to represent early events in ischemia, infections, or traumatic brain injury. Experimental data for glial [Cl–]int are lacking for most brain regions, under normal as well as under pathological conditions. We measured [Cl–]int in hippocampal and neocortical astrocytes and in hippocampal radial glia-like (RGL) cells in acute murine brain slices using fluorescence lifetime imaging microscopy with the chloride-sensitive dye MQAE at room temperature. We observed s…

Hemodynamic Changes During Physiological and Pharmacological Stress Testing in Healthy Subjects, Aortic Stenosis and Aortic Coarctation Patients–A Sy…

2019

Introduction: Exercise testing has become a diagnostic standard in the evaluation and management of heart disease. While different methods of exercise and pharmacological stress testing exist, only little is known about their comparability. We aimed to assess hemodynamic changes during dynamic exercise, isometric exercise, and dobutamine stress testing at different stress intensities in healthy subjects and patients with aortic stenosis (AS) and aortic coarctation (CoA).Methods: A systematic literature search (PROSPERO 2017:CRD42017078608) in MEDLINE of interventional trials was conducted to identify eligible studies providing evidence of changes in hemodynamic parameters under different st…

Novel Perspectives in the Detection of Oral and Nasal Oxidative Stress and Inflammation in Pediatric United Airway Diseases

2010

United airway disease (UAD) concept proposed that asthma and rhinitis are both different clinical manifestation of a single inflammatory process. The aim of this study is to assess in upper and lower airways the level of inflammation and oxidative stress and to investigate the relationship between biomarkers in persistent allergic rhinitis (PER) and in concomitant asthma with PER. By a crosssectional study we measured oral and nasal (FENO) and oral and nasal EBC 8-isoprostane, LTB4 and PGE2 in children with PER (n=14) and with PER and concomitant intermittent asthma (IA; n=25), mild persistent asthma (mA; n=28), moderate persistent asthma (MA; n=13) and in Healthy Controls (HCs; n=13). Oral…

Empīriskajā metodē izstrādāto aktivitāšu ietekme angļu valodas runātprasmes apguvei 11. klases skolēniem Rīgas tehnikumā

2019

Diplomdarbā tiek pētīts, kā empīriskajā metodē izstrādātās aktivitātes uzlabo skolēnu runas prasmes, samazina stresu un baiļu sajūtu no runāšanas. Mērķis ir izstrādāt uz empīrisko metodi balstītas apmācību aktivitātes un izpētīt, kā tas veicina skolnieku runas prasmju attīstīšanu un vai motivē aktīvi piedalīties apmācības procesā. Teorētiskajā daļā ir pētīta runas prasme, empīriskās apmācības teorija un tās pielietošana apmācībās procesā. Empīriskajā daļā atspoguļoti metodes pielietošanas rezultāti. Sākotnējās pārbaudes rezultātu analīze, salīdzinot ar starppārbaudes un gala pārbaudes rezultātiem, pierādīja, ka skolnieku grupai, kuri bija iesaistīti eksperimentā, uzlabojās runas prasme, sam…

Progressi sperimentali e numerici nella valutazione dell'integrita strutturale dei solidi mediante Thermoelastic Stress Analysis

2023

The Role of Individual- and Macro-Level Social Determinants on Young Adolescents’ Psychosomatic Complaints

2011

This study examines the social determinants of psychosomatic complaints in young adolescents. Using data from the Health Behaviour in School-aged Children (HBSC) study, psychosomatic complaints are studied in 98,773 adolescents (11- and 13-year-olds; 48% 11-year-olds, 52% 13-year-olds; 52% females, 48% males) from 34 European countries. Individual-level determinants, including family-, peer- and school-related factors as well as country-level determinants (Human Development Index [HDI]) are considered. In line with existing evidence, results revealed more psychosomatic complaints in young adolescents experiencing stress inducing familial-, peer- and school-related factors. Negative effects…

Stress darbā un veselības veicināšanas pasākumi farmaceitiem

2018

“Stress darbā un veselības veicināšanas pasākumi farmaceitiem.” Darba autore Linda Grabovska. Darba zinātniskā vadītāja: Dr. med., asociētā profesore Ženija Roja. Maģistra darbs izklāstīts uz 70 lpp., ietver 21 attēlu, 9 tabulas, 7 pielikumus, 56 informatīvos avotus. Maģistra darbā ir pētīti stresa indikatori aptiekās strādājošajiem darbiniekiem un kā kontroles grupa piesaistīti dažādu nozaru biroja darbinieki. Stress ir bieža sastopama parādība darba vietās, kas negatīvi ietekmē darbinieka veselību, ko bieži izraisa darba vides riski un psihoemocionālā slodze. Darbs sastāv no trīs daļām. Pirmajā daļā analizēta pieejamā literatūra par pētām…