Search results for " STRESS"
showing 10 items of 3936 documents
Does Bacillus thuringiensis Affect the Stress and Immune Responses of Rhynchophorus ferrugineus Larvae, Females, and Males in the Same Way?
2022
Simple Summary Rhynchophorus ferrugineus is a destructive quarantine pest of palm trees, now widely distributed. Although broad-spectrum insecticides are often used to protect palm against R. ferrugineus, there is increasing concern about their effects on the environment and human health, especially where palm trees are located in urban areas. As an environmentally friendly entomopathogen, Bacillus thuringiensis (Bt) has been widely used to prevent other pest infestations. Although Bt products are the most sold bio-insecticides, there are still many interesting features to be investigated in the relationship of Bt and its hosts. We investigated the effect of Bt on larvae, females, and males…
The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value
2021
AbstractIron is a fundamental nutrient utilized by living cells to support several key cellular processes. Despite its paramount role to sustain cell survival, excess of labile iron availability can inflict severe cell damage via reactive oxygen species generation which, in turn, can promote neoplastic transformation. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tensions herein present. Moreover, cigarette smoke as well as air pollution particulate can function as vehicles of iron supply, leading to an iron dysregulation condition shown to be crucial in the pathogenesis of several respiratory diseases including lung cancer. Hephaestin (HEPH) bel…
Jauna dihidropiridīna atvasinājuma AV-6-93 efekts uz biomarķiera BDNF ekspresiju stresa modelī žurkām
2015
Stresa izraisītie atmiņas bojājumi ir iemesls jaunu zāļu vielu meklējumiem, kas spētu aizkavēt smadzeņu bojājumus. Mūsu pētījuma mērķis bija noteikt jauna Latvijas Organiskās sintēzes institūtā sintezētās zāļu vielas AV-6-93, kas sastāv no dihidropiridīna un adamantāna atvasinājumiem, ietekmi uz neirotrofā faktora BDNF ekspresiju imobilizācijas stresētām žurkām hipokampā ar Western blota metodi. Petījuma rezultāti rāda, ka imobilizācijas stress ir palielinājis BDNF ekspresiju žurku hipokampā salīdzinājumā ar kontroles hipokampa žurkām, un AV-6-93 piemīt spēja normalizēt BDNF ekspresiju stresēto žurku hipokampā. Mūsu dati rāda, ka nepieciešams turpināt pētīt šī savienojuma molekulāros mehāni…
Metallic nanoparticles exhibit paradoxical effects on oxidative stress and pro-inflammatory response in endothelial cells in vitro
2007
Particulate matter is associated with different human diseases affecting organs such as the respiratory and cardiovascular systems. Very small particles (nanoparticles) have been shown to be rapidly internalized into the body. Since the sites of internalization and the location of the detected particles are often far apart, a distribution via the blood stream must have occurred. Thus, endothelial cells, which line the inner surface of blood vessels, must have had direct contact with the particles. In this study we tested the effects of metallic nanoparticles (Co and Ni) on oxidative stress and proinflammatory response in human endothelial cells in vitro. Exposure to both nanoparticle types…
Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells E…
2022
Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is authorized as a drug for the treatment of Leber’s hereditary optic neuropathy. Mitochondria of retinal pigment epithelium (RPE) are particularly vulnerable to oxidative damage associated with cellular senescence. Therefore, the aim of this study was to explore idebenone’s cytoprotective effect and its underlying mechanism. We used a human-RPE cell line (ARPE-19) exposed to idebenone pre-treatment for 24 h followed by conditions …
Development and validation of new methods for the study of oxidative stress by Imaging Flow Cytometry
2017
El estrés oxidativo se origina debido a un desequilibrio entre la producción de especies reactivas de oxígeno (ROS) y los mecanismos celulares antioxidantes. Este desequilibrio en el estado normal redox puede causar efectos tóxicos a través de la producción de radicales libres y peróxidos, que dañan a componentes esenciales de la célula, como proteínas, lípidos y ADN. Actualmente se cree que el estrés oxidativo está relacionado con los mecanismos en un gran número de enfermedades degenerativas y cáncer, y también se le atribuye un papel importante en el proceso de envejecimiento. En algunos casos, la producción de especies reactivas de oxígeno (ROS) no es un fenómeno indeseable sino que for…
Variation of environmental condition and diet act on immune parameters of Mytilus galloprovinciali
2015
Variation of environmental condition and diet act on immune parameters of Mytilus galloprovincialis The knowledge of the immunity mechanisms as environmental indicators and their alterations in the case of physical stress can be of fundamental importance in the environmental management programs. Recently has been shown that environmental factors affect immune responses in some species of bivalves. In this study we assessed different enzymatic activities from digestive gland of M. galloprovincialis such esterase, phosphatase and phenoloxidase (PO), involved in digestive inflammatory, detoxification and melanization processes. Particularly, esterases catalyze the hydrolysis reaction of the es…