Search results for " Spin"
showing 10 items of 1036 documents
Apical dendritic spines and axonic terminals in the bipyramidal neurons of the dorsomedial cortex of lizards (Lacerta).
1984
Gold-toned bipyramidal neurons of the dorsomedial cortex of Lacerta have been studied using light and electron microscopy. The spines have been classified as stubby, mushroom-shaped or thin. Thin and mushroom-shaped spines are only found on proximal and intermediate dendritic segments, whereas stubby spines are found on distal dendritic segments. A Timm's method modification for electron microscopy (sulphide-osmium procedure) has been used. Timm-positive axonal endings usually synapse on thin and mushroom-shaped spines, whereas Timm-negative axonal endings usually synapse on stubby spines. Timm-positive afferents and their post-synaptic spines on bipyramidal neurons of Lacerta's dorsomedial…
Dorsal root ganglia neurite outgrowth measured as a function of changes in microelectrode array resistance
2017
Current research in prosthetic device design aims to mimic natural movements using a feedback system that connects to the patient's own nerves to control the device. The first step in using neurons to control motion is to make and maintain contact between neurons and the feedback sensors. Therefore, the goal of this project was to determine if changes in electrode resistance could be detected when a neuron extended a neurite to contact a sensor. Dorsal root ganglia (DRG) were harvested from chick embryos and cultured on a collagen-coated carbon nanotube microelectrode array for two days. The DRG were seeded along one side of the array so the processes extended across the array, contacting a…
Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis
2013
Type-1 cannabinoid receptors (CB1R) are important regulators of the neurodegenerative damage in multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis (EAE). In GABAergic striatal neurons, CB1R stimulation exerts protective effects by limiting inflammation-induced potentiation of glutamate-mediated spontaneous excitatory postsynaptic currents (sEPSCs). Here we show that CB1R located on GABAergic or on glutamatergic neurons are differentially involved in the pre- and postsynaptic alterations of sEPSCs caused by EAE in the striatum. After induction of EAE, mice selectively lacking CB1R on GABAergic neurons (GABA-CB1R-KO) showed exacerbated alterations of sEPSC duration in GA…
Novel clinical insights into spinal hemangioblastoma in adults: a systematic review
2021
ABSTRACT Background Hemangioblastomas are well vascularized, benign CNS tumors and the third most common primary spinal cord tumor after astrocytoma/ependymoma, occurring sporadically or as a part of an autosomal dominant von Hippel-Lindau disease in which tumors are often multiple and prone to relapse. Spinal hemangioblastomas are commonly located in the cervical cord and associated with a syrinx formation. Due to location and growth trends, they may cause significant neurological deficit, impairing patient quality of life. We conducted a systematic review to understand better clinical insights of spinal hemangioblastoma in adults and compare spinal hemangioblastoma versus posterior crania…
Presurgical role of MRI tractography in a case of extensive cervicothoracic spinal ependymoma
2017
Background: Intramedullary spinal ependymoma is a tumor, hardly characterizable with conventional magnetic resonance (MR) imaging only. MR diffusion tensor imaging (DTI) with three dimensional fiber tracking reconstructions allows the evaluation of the relationship between neoplasm and white matter fiber tracts, being a powerful tool in presurgical planning. We present DTI findings in a case of a young female with an extensive cervicothoracic spinal ependymoma. Case Description: The patient complained of a 2 month history of acute urinary retention, weakness and numbness on the lower limbs and the upper left limb. She underwent MR imaging that showed an extensive cervicothoracic spinal mass…
Desenvolupament de les habilitats matemàtiques en alumnat amb espina bífida: revisió bibliogràfica
2019
espanolEl alumnado con Espina Bifida presenta dificultades a la hora de desarrollar sus habilidades matematicas. Se ha analizado con profundidad el concepto de Espina Bifida, para tener una primera vision de lo que este conlleva. Para la revision se ha realizado una busqueda bibliografica en las bases de datos scopus, Dialnet y Google Academico, seleccionando 18 articulos objeto de analisis. Los resultados obtenidos han permitido dar respuesta a los objetivos planteados, obteniendo informacion sobre los enfoques practicos en el area de matematicas con este colectivo y analizar, asi, la efectividad de los mismos. Ademas, en las conclusiones extraidas, se encuentra la necesidad de llevar a ca…
Ligand-Binding Cooperativity Effects in Polymer-Protein Conjugation.
2019
We present an electron paramagnetic resonance (EPR) spectroscopic characterization of structural and dynamic effects that stem from post-translational modifications of bovine serum albumin (BSA), an established model system for polymer-protein conjugation. Beyond the typical drug delivery and biocompatibility aspect of such systems, we illustrate the causes that alter internal dynamics and therefore functionality in terms of ligand-binding to the BSA protein core. Uptake of the paramagnetic fatty acid derivative 16-doxyl stearic acid by several BSA-based squaric acid macroinitiators and polymer-protein conjugates was studied by EPR spectroscopy, aided by dynamic light scattering (DLS) and z…
Corporate spin-offs value creation : parent & spin-off view
2015
Corporate spin-offs have gained popularity over the past few years. Despite of this in Finnish media and university teaching this phenomenon has gained little attention. This study aims to fulfill this knowledge gap. Spin-off is a restructuring procedure where company splits into two separate legal entities via pro-rata transaction basis. I researched this phenomenon by event-study methodology which has been quite popular also in earlier studies. I have com-pared parent and spin-off stock performance in order to reveal potential value gains for investors. Parent company is analyzed also from the announcement period where we find strong positive abnormal returns associated with announcement …
Thoracic spinal extradural arachnoid cyst: A case report and literature review
2022
Background: Spinal extradural arachnoid cysts (SEDACs) are rare and are variously attributed to congenital, traumatic, or inflammatory etiologies. Here, we report a 70-year-old male who presented with a T11-T12 SEDAC and an incidental craniovertebral junction (CVJ) meningioma. Case Description: A 70-year-old male presented with progressive bilateral lower limb weakness and paresthesias. The thoracic MRI identified an extradural arachnoid cystic lesion at the T11-T12 level. In addition, the brain/ cervical MR documented an incidental meningioma at the CVJ. The patient underwent T11-T12 laminectomy for fenestration/removal of the extradural arachnoid cyst resulting in immediate cord decompre…
The spin-1/2 Kagome XXZ model in a field: competition between lattice nematic and solid orders
2016
We study numerically the spin-1/2 XXZ model in a field on an infinite Kagome lattice. We use different algorithms based on infinite Projected Entangled Pair States (iPEPS) for this, namely: (i) with simplex tensors and 9-site unit cell, and (ii) coarse-graining three spins in the Kagome lattice and mapping it to a square-lattice model with nearest-neighbor interactions, with usual PEPS tensors, 6- and 12-site unit cells. Similarly to our previous calculation at the SU(2)-symmetric point (Heisenberg Hamiltonian), for any anisotropy from the Ising limit to the XY limit, we also observe the emergence of magnetization plateaus as a function of the magnetic field, at $m_z = \frac{1}{3}$ using 6-…