Search results for " System P"
showing 10 items of 181 documents
Logical Operations among Conditional Events: theoretical aspects and applications
2019
We generalize the notions of conjunction and disjunction of two conditional events to the case of $n$ conditional events. These notions are defined, in the setting of coherence, by means of suitable conditional random quantities with values in the interval $[0,1]$. We also define the notion of negation, by verifying De Morgan's Laws. Then, we give some results on coherence of prevision assessments for some families of compounded conditionals and we show that some well known properties which are satisfied by conjunctions and disjunctions of unconditional events are also satisfied by conjunctions and disjunction of conditional events. We also examine in detail the coherence of the prevision a…
ATTEMPTS TO ISOLATE C'3 ACTIVITY FROM PIG SERUM.
1965
Gli autori descrivono un metodo per l'isolamento del terzo componente del complemento dal siero di maiale, basato sulla possibilita di provocare, per aggiunta di lisozima, passaggio in soluzione del C′3 precipitato insieme ad altre proteine in seguito all'aggiunta di opportune quantita di « Liquoid » al siero.
Activation of complement by the alternative pathway as a factor in the pathogenesis of periodontal disease.
1976
Dental plaque and a bacterium, Actinomyces viscosus, isolated from plaque that can reproduce periodontal disease in germ-free rats, are activators of complement by the alternative pathway. It is suggested that this process is involved in the pathogenesis of chronic inflammatory periodontal disease.
Host immune response to Cryptosporidium parvum infection
2010
Species of the genus Cryptosporidium are protozoan parasites (Apicomplexa) that cause gastroenteritis in animals and humans. Of these Cryptosporidium parvum and Cryptosporidium hominis are the major causative agents of human cryptosporidiosis. Whereas infection is self-limiting in the immunocompetent hosts, immunocompromised individuals develop a chronic, life-threatening disease. As specific therapeutic or preventive interventions are not yet available, better understanding of the immune response to the parasite is required. This minireview briefly summarizes the factors involved in the innate and acquired immune response in this pathogen-host interaction with an emphasis on more recent da…
A central nervous system-focused treatment approach for people with frozen shoulder: protocol for a randomized clinical trial
2019
Background: Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist. The aim of this study will be to compare the effectiveness of a central nervous system (CNS)-directed treatment program versus a standard medical and physical therapy care program on outcomes in participants with FS. Methods/design: The study is a two-group, randomized clinical trial with blinding of participants and assessors. Participants will be recruited via referrals fr…
On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety.
1995
Combined treatment with trypsin, cholesterol esterase, and neuraminidase transforms LDL, but not HDL or VLDL, to particles with properties akin to those of lipid extracted from atherosclerotic lesions. Single or double enzyme modifications, or treatment with phospholipase C, or simple vortexing are ineffective. Triple enzyme treatment disrupts the ordered and uniform structure of LDL particles, and gives rise to the formation of inhomogeneous lipid droplets 10-200 nm in diameter with a pronounced net negative charge, but lacking significant amounts of oxidized lipid. Enzymatically modified LDL (E-LDL), but not oxidatively modified LDL (ox-LDL), is endowed with potent complement-activating c…
PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery.
2019
Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing within PML NBs. Often, large DNA viruses disassemble and reorganize PML NBs to counteract their intrinsic antiviral activity and support establishment of infection. However, human papillomavirus (HPV) requires PML protein to retain incoming viral DNA in the nucleus for subsequent efficient transcription. In contrast, Sp100 was identified as a restriction factor for HPV. These findings suggested that PML NBs are important regulators of early stages o…
Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system
2007
Although mucosal immune responses are critical for protection of hosts from clinical illness and even mortality caused by mucosal pathogens, the molecular mechanism of mucosal immunity, which is independent of systemic immunity, remains elusive. To explore the mechanistic basis of mucosal protective immunity, gene transcriptional profiling in mucosal tissues was evaluated after the primary and secondary immunization of animals with an attenuated avian infectious bronchitis virus (IBV), a prototype of Coronavirus and a well-characterized mucosal pathogen. Results showed that a number of innate immune factors including toll-like receptors (TLRs), retinoic-acid-inducible gene-1 (RIG-1), type I…
The efficacy of two immunostimulants against Flavobacterium columnare infection in juvenile rainbow trout (Oncorhynchus mykiss).
2009
Abstract Bacterium Flavobacterium columnare is the causative agent of columnaris disease in many wild and farmed fish species. Immunostimulants are used with success in aquaculture against many pathogens, but the ability to improve innate resistance to columnaris disease has not been studied. Fingerling rainbow trout were treated with two immunostimulants, yeast β-glucan and β-hydroxy-β-methylbutyrate (HMB). Selected innate immune function parameters, the production of reactive oxygen species (ROS) by whole blood and by isolated head kidney leukocytes, plasma lysozyme activity and complement bacteriolytic activity, were determined to assess the immune status of fish. The fish were then bath…
EU transition in power sector
2019
Abstract In the past, much of Europe’s electricity grid network has been designed in consideration of the locations of conventional generation plants. However, a large share of today's renewables production – notably variable wind and solar – does not correspond to this grid architecture. Interconnectors, in addition to internal infrastructure, are key to creating new electricity corridors to connect areas of surplus to areas of scarcity. In this context, in 2014 the European Council, in recognizing that a fundamental role of transmission infrastructure is to enable the integration of areas of high renewable energy potential with main consumption areas, endorsed the proposal by the European…