Search results for " Urinary"

showing 10 items of 569 documents

Fetal neurogenesis: breathe HIF you can.

2016

Blood vessels are part of the stem cell niche in the developing cerebral cortex, but their in vivo role in controlling the expansion and differentiation of neural stem cells (NSCs) in development has not been studied. Here, we report that relief of hypoxia in the developing cerebral cortex by ingrowth of blood vessels temporo‐spatially coincided with NSC differentiation. Selective perturbation of brain angiogenesis in vessel‐specific Gpr124 null embryos, which prevented the relief from hypoxia, increased NSC expansion at the expense of differentiation. Conversely, exposure to increased oxygen levels rescued NSC differentiation in Gpr124 null embryos and increased it further in WT embryos, s…

0301 basic medicineNeurogenesisNicheNeovascularization PhysiologicBiologyCell fate determinationGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesMiceFetusNeural Stem CellsmedicineAnimalsHumansNews & ViewsHypoxiaMolecular BiologyCentral elementreproductive and urinary physiologyCell ProliferationCerebral CortexFetusGeneral Immunology and MicrobiologyGeneral NeuroscienceNeurogenesisCell DifferentiationArticlesHypoxia-Inducible Factor 1 alpha Subunitnervous system diseasesOxygen030104 developmental biologymedicine.anatomical_structurenervous systemCerebral cortexImmunologyNeuronStem cellbiological phenomena cell phenomena and immunityNeuroscienceGlycolysisThe EMBO journal
researchProduct

Olfactory system in mammals: structural and functional anatomy

2016

Olfactory system in mammals: structural and functional anatomy

0301 basic medicineOlfactory systemanatomy[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutritionanimal diseasesmammalOlfactionBiology03 medical and health sciencesPrimary olfactory cortex0302 clinical medicineparasitic diseasesmedicinereproductive and urinary physiologyOlfactory receptorfungiAnatomyolfactoryOlfactory bulb[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition030104 developmental biologymedicine.anatomical_structurecortexFunctional anatomyepitheliumOlfactory epithelium[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition030217 neurology & neurosurgery
researchProduct

Residual tumor micro-foci and overwhelming regulatory T lymphocyte infiltration are the causes of bladder cancer recurrence

2016

Bladder cancer has an unexplained, high recurrence rate. Causes of recurrence might include the presence of sporadic tumor micro-foci in the residual urothelial tissue after surgery associated with an inverted ratio between intratumoral effector and regulatory T cell subsets. Hence, surgical specimens of both tumors and autologous, macroscopically/histologically free-of-tumor tissues were collected from 28 and 20 patients affected by bladder or renal cancer, respectively. The frequencies of effector (IFNγ+ and IL17+ T cells) and regulatory (CD4+CD25hiCD127lo and CD8+CD28-CD127loCD39+ Treg) T cell subpopulations among tumor infiltrating lymphocytes were analyzed by immunofluorescence, while …

0301 basic medicinePathologyNeoplasm ResidualT-LymphocytesMessengerImmunoenzyme TechniqueFluorescent Antibody TechniqueCD8-Positive T-LymphocytesT-Lymphocytes RegulatoryImmunoenzyme TechniquesTh10302 clinical medicineLymphocytesReverse Transcriptase Polymerase Chain ReactionResearch Paper: ImmunologyPrognosisRegulatoryBladder cancer; Immune response; Immunity; Immunology and microbiology section; Mage; Th1; Th17; Tumor infiltrating lymphocytes; CD8-Positive T-Lymphocytes; Case-Control Studies; Fluorescent Antibody Technique; Follow-Up Studies; Humans; Immunoenzyme Techniques; Lymphocytes Tumor-Infiltrating; Melanoma-Specific Antigens; Neoplasm Grading; Neoplasm Proteins; Neoplasm Recurrence Local; Neoplasm Staging; Neoplasm Residual; Prognosis; RNA Messenger; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes Regulatory; Urinary Bladder Neoplasms; OncologyNeoplasm Proteinsmedicine.anatomical_structureLocalOncologytumor infiltrating lymphocytesResidual030220 oncology & carcinogenesisImmunology and Microbiology Sectionbladder cancerTh17Case-Control StudieMelanoma-Specific AntigenMelanoma-Specific AntigensHumanmedicine.medical_specialtyPrognosiRegulatory T cellT cellReal-Time Polymerase Chain ReactionMAGEFollow-Up StudieNeoplasm Protein03 medical and health sciencesLymphocytes Tumor-InfiltratingImmune systemAntigenmedicineHumansTumor-InfiltratingRNA MessengerImmune responseNeoplasm StagingBladder cancerTumor-infiltrating lymphocytesbusiness.industryImmunityCD8-Positive T-LymphocyteT lymphocytemedicine.diseaseNeoplasm Recurrence030104 developmental biologyUrinary Bladder NeoplasmsCase-Control StudiesNeoplasmRNANeoplasm GradingNeoplasm Recurrence Localtumor infiltrating lymphocytebusinessCD8Follow-Up StudiesOncotarget
researchProduct

Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts

2016

The research leading to these results was funded by the Spanish Ministry of Health (FIS-PI11/00610, FIS-PI041436, FIS-PI081151, FIS-PI042018, and FIS-PI09/02311), the European Union (EU) (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), the Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/01007, 11/02591, CP11/00178, FIS-PI06/0867, and FIS-PS09/00090), the Conselleria de Sanitat Generalitat Valenciana, the Generalitat de Catalunya-CIRIT (1999SGR 00241), the Obre Social Cajastur, the Universidad de Oviedo, the Department of Health of the Basque Government (2005111093 and 2009111069),…

0301 basic medicinePediatrics:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Birth Weight [Medical Subject Headings]:Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Fetal Development [Medical Subject Headings]Health Toxicology and MutagenesisPlacentaEspañaPhysiology:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Growth Disorders::Fetal Growth Retardation [Medical Subject Headings]ADN mitocondrial010501 environmental sciencesMitochondrion01 natural sciencesFetal DevelopmentBélgicaPregnancyBirth Weightskin and connective tissue diseasesPeso al nacerNews | Science SelectionsMitocondrias:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]:Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria [Medical Subject Headings]2. Zero hunger:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]Air PollutantsAmbient air pollutionAire -- ContaminacióFemenino3. Good healthmedicine.anatomical_structureMaternal ExposureFemaleBirth cohort:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Air Pollution [Medical Subject Headings]Mitochondrial DNAmedicine.medical_specialtyModelos LinealesEmbarazoBirth weightInfants -- DesenvolupamentBiology:Chemicals and Drugs::Inorganic Chemicals::Gases::Nitrogen Oxides::Nitrogen Dioxide [Medical Subject Headings]DNA Mitochondrial:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes Mitochondrial [Medical Subject Headings]03 medical and health sciencesAir pollutantsPlacentaAir PollutionmedicineHumans:Geographicals::Geographic Locations::Europe::Belgium [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Linear Models [Medical Subject Headings]Contaminación del aire0105 earth and related environmental sciencesRetardo del crecimiento fetal:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::DNA::DNA Circular::DNA Mitochondrial [Medical Subject Headings]Genes mitocondrialesPregnancyPublic Health Environmental and Occupational HealthDesarrollo fetalmedicine.disease:Anatomy::Embryonic Structures::Placenta [Medical Subject Headings]030104 developmental biology:Check Tags::Female [Medical Subject Headings]13. Climate actionSpainsense organsDióxido de nitrógeno
researchProduct

Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis

2016

Twin pregnancies are at increased risk of stillbirth. Uncomplicated twin pregnancies are commonly delivered earlier to prevent stillbirth; however, there is a risk of neonatal complications associated with being born prior to 39 weeks’ gestation. The optimal gestational age for delivery in twin pregnancies is unknown and likely varies by chorionicity. The present study aimed to determine the prospective risk of stillbirth in women with uncomplicated monochorionic and dichorionic twin pregnancies, and neonatal mortality risks, when delivered beyond 34 weeks of gestation. Data on twin pregnancies that reported rates of stillbirth were obtained from MEDLINE, EMBASE, and Cochrane Library. Separ…

0301 basic medicinePediatricsNeonatal intensive care unitPerinatal DeathCochrane LibraryInfant Newborn Diseases0302 clinical medicineObstetrics and gynaecologyPregnancyRisk FactorsTwins DizygoticMedicineProspective StudiesProspective cohort studyreproductive and urinary physiologyTwin Pregnancyhealth care economics and organizations030219 obstetrics & reproductive medicineObstetricsIncidence (epidemiology)Absolute risk reductionObstetrics and GynecologyGestational ageProspective riskGeneral MedicineStillbirthfemale genital diseases and pregnancy complicationsMeta-analysisGestationFemalemedicine.medical_specialtyeducationGestational AgeTwin-to-twin transfusion syndrome03 medical and health sciences030225 pediatricsJournal ArticleHumansGynecologyPregnancybusiness.industryResearchInfant NewbornTwins Monozygoticmedicine.diseaseConfidence interval030104 developmental biologyIntensive Care NeonatalPregnancy TwinbusinessBMJ (Clinical research ed.)
researchProduct

Postpartum listeria meningitis

2020

Highlights • Listeria monocytogenes is a rare cause of meningitis in immunocompetent patient. • Pregnancy and puerperium are accompanied by a decrease in cellular immunity. • Pregnancy and puerperium should be considered as risk factors for invasive listeriosis.

0301 basic medicinePediatricsmedicine.medical_specialty030106 microbiologyInfectious and parasitic diseasesRC109-216DiseaseAbortionmedicine.disease_causeAsymptomaticArticle03 medical and health sciences0302 clinical medicineImmune systemListeria monocytogenesmedicineMeningitis030212 general & internal medicinereproductive and urinary physiologyListeria monocytogenePregnancybusiness.industryPuerperiummedicine.diseaseAntimicrobialListeria monocytogenesfemale genital diseases and pregnancy complicationsMeningitiInfectious Diseasesmedicine.symptombusinessMeningitisIDCases
researchProduct

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury.

2018

Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-contai…

0301 basic medicineRHOAanimal structuresventricular-subventricular zoneBiology03 medical and health sciences0302 clinical medicinegait behaviorNeuroblastCell MovementNeuroblast migrationLateral VentriclesGeneticsmedicineAnimalsreproductive and urinary physiologyN-cadherinNeuronsneuronal migrationneuronal regenerationneonatal brain injuryCadherinEmbryogenesisfungiCell Biologypostnatal neurogenesisRecovery of FunctionCadherinsEmbryonic stem cellNeural stem cellRadial glial cell030104 developmental biologymedicine.anatomical_structurenervous systemAnimals NewbornBrain Injuriesbiology.proteinMolecular MedicinerhoA GTP-Binding ProteinNeuroscienceNeuroglia030217 neurology & neurosurgeryradial glial cellCell stem cell
researchProduct

2016

AbstractStem cells control their mitotic activity to decide whether to proliferate or to stay in quiescence. Drosophila neural stem cells (NSCs) are quiescent at early larval stages, when they are reactivated in response to metabolic changes. Here we report that cell-contact inhibition of growth through the canonical Hippo signalling pathway maintains NSC quiescence. Loss of the core kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator Yorkie and initiation of growth and proliferation in NSCs. Yorkie is necessary and sufficient for NSC reactivation, growth and proliferation. The Hippo pathway activity is modulated via inter-cellular transmembran…

0301 basic medicineRegulation of gene expressionHippo signaling pathwayanimal structuresMultidisciplinaryGeneral Physics and AstronomyGeneral ChemistryBiologyGeneral Biochemistry Genetics and Molecular BiologyHedgehog signaling pathwayNeural stem cellnervous system diseasesCell biology03 medical and health sciences030104 developmental biologynervous systembiological phenomena cell phenomena and immunitySignal transductionStem cellMitosisreproductive and urinary physiologyDrosophila ProteinNature Communications
researchProduct

TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn.

2019

Ten-eleven-translocation (TET) proteins catalyze DNA hydroxylation, playing an important role in demethylation of DNA in mammals. Remarkably, although hydroxymethylation levels are high in the mouse brain, the potential role of TET proteins in adult neurogenesis is unknown. We show here that a non-catalytic action of TET3 is essentially required for the maintenance of the neural stem cell (NSC) pool in the adult subventricular zone (SVZ) niche by preventing premature differentiation of NSCs into non-neurogenic astrocytes. This occurs through direct binding of TET3 to the paternal transcribed allele of the imprinted gene Small nuclear ribonucleoprotein-associated polypeptide N (Snrpn), contr…

0301 basic medicineScienceCellular differentiationGeneral Physics and AstronomySubventricular zone02 engineering and technologyBiologyDNA-binding proteinArticleGeneral Biochemistry Genetics and Molecular BiologyCatalysissnRNP Core ProteinsDioxygenases03 medical and health sciencesMiceNeural Stem CellsLateral VentriclesProto-Oncogene ProteinsmedicineAnimalsRNA Small Interferinglcsh:SciencePsychological repressionreproductive and urinary physiologyMultidisciplinarySnRNP Core ProteinsQNeurogenesisBrainCell DifferentiationGeneral Chemistry021001 nanoscience & nanotechnologyNeural stem cellnervous system diseasesCell biologyDNA-Binding Proteins030104 developmental biologymedicine.anatomical_structurenervous systemAstrocyteslcsh:Qbiological phenomena cell phenomena and immunity0210 nano-technologyGenomic imprintingSignal Transduction
researchProduct

Activin and inhibin A in predicting outcome of pregnancies of unknown location after ART

2018

Abstract The aim was to investigate the predictive value of a single serum determination of activin A and inhibin A for classifying pregnancies of unknown location (PUL) after IVF cycles in both own fresh and donated oocytes. A case–control study conducted in a University-affiliated IVF center. Pregnancy outcomes after own fresh oocytes included 12 failing PUL, 12 ectopic pregnancies (EP) and a control group of 24 singleton intrauterine pregnancies (IUP). The same scheme was followed for the oocyte donation recipients. Inhibin A, activin A, β-hCG and Progesterone (P) were determined. In the own fresh oocytes IVF, the AUC for predicting EP vs. f failing PUL were: Activin A: 0.458 and Inhibin…

0301 basic medicineendocrine systemPregnancyInhibin a030219 obstetrics & reproductive medicineEctopic pregnancybusiness.industryActivin and inhibinmedicine.diseasefemale genital diseases and pregnancy complicationsActivin aAndrology03 medical and health sciences030104 developmental biology0302 clinical medicineInduced ovulationOocyte donationMedicineBiomarker (medicine)businessreproductive and urinary physiologyhormones hormone substitutes and hormone antagonistsMedicina Reproductiva y Embriología Clínica
researchProduct