Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury.

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RESEARCH PRODUCT

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury.

Takaki Miyata José Manuel García-verdugo Toshihiro Akaike Takuya Miyamoto Naoko Kaneko Kazunobu Sawamoto Kazunobu Sawamoto Itsuki Ajioka Shinji Saitoh Hideo Jinnou Yasuhiko Tabata Takumi Kawaue Masato Sawada Koya Kawase Vicente Herranz-perez Vicente Herranz-pérez

subject

0301 basic medicine RHOA animal structures ventricular-subventricular zone Biology 03 medical and health sciences 0302 clinical medicine gait behavior Neuroblast Cell Movement Neuroblast migration Lateral Ventricles Genetics medicine Animals reproductive and urinary physiology N-cadherin Neurons neuronal migration neuronal regeneration neonatal brain injury Cadherin Embryogenesis fungi Cell Biology postnatal neurogenesis Recovery of Function Cadherins Embryonic stem cell Neural stem cell Radial glial cell 030104 developmental biology medicine.anatomical_structure nervous system Animals Newborn Brain Injuries biology.protein Molecular Medicine rhoA GTP-Binding Protein Neuroscience Neuroglia 030217 neurology & neurosurgery radial glial cell

description

Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries.

year	journal	country	edition	language
2018-01-01	Cell stem cell

10.1016/j.stem.2017.11.005 https://pubmed.ncbi.nlm.nih.gov/29304341