0000000000162252
AUTHOR
Toshihiro Akaike
showing 3 related works from this author
Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell–cell Adhesion in the Postnatal Brain
2018
In the rodent olfactory system, neuroblasts produced in the ventricular-subventricular zone of the postnatal brain migrate tangentially in chain-like cell aggregates toward the olfactory bulb (OB) through the rostral migratory stream (RMS). After reaching the OB, the chains are dissociated and the neuroblasts migrate individually and radially toward their final destination. The cellular and molecular mechanisms controlling cell–cell adhesion during this detachment remain unclear. Here we report that Fyn, a nonreceptor tyrosine kinase, regulates the detachment of neuroblasts from chains in the male and female mouse OB. By performing chemical screening andin vivoloss-of-function and gain-of-f…
Structural Characterization of Glycoconjugate Polystyrene in Aqueous Solution
1999
Maltopentaose-carrying polystyrene was synthesized by the homopolymerization of vinylbenzyl maltopentaose amide. Resulted amphiphilc polymacromonomer was dissolved in 0.1 M urea aqueous solution, and its structure was characterized by small-angle X-ray scattering and molecular modeling. Maltopentaose-carrying polystyrene polymacromonomer was found to be represented by a molecular bottlebrush, composed of a large helix of polystyrene backbone and maltopentaose brushes. The molecular bottlebrush seems to be distributed randomly or many even be broken once or twice in segments with no apparent intersegmental spatial correlation. A large helix of polystyrene backbone is formed by a random seque…
Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury.
2018
Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-contai…