Search results for " VAS"
showing 10 items of 1524 documents
Endothelin receptors mediating contraction in goat cerebral arteries
1993
1. The aim of the present study was to identify the subtype of receptor mediating contraction to endothelin-1 and sarafotoxin S6b in goat isolated middle cerebral arteries. 2. Endothelin-1, endothelin-2 and endothelin-3 contracted cerebral arteries in a concentration-dependent manner. Although the three peptides were full agonists, the order of potency was endothelin-1 = endothelin-2 > endothelin-3, with a relative potency of endothelin-1 and endothelin-2 versus endothelin-3 of approximately 280. Sarafotoxin S6b induced concentration-dependent contractions with lower potency than endothelin-1/endothelin-2, higher potency than endothelin-3 and a higher maximum response than the three endothe…
Functional evidence of inverse agonism in vascular smooth muscle
1996
1. In the present study, depletion of internal Ca2+ stores sensitive to noradrenaline (1 microM) in rat aorta, is the signal for the entry of extracellular Ca2+, not only to refill the stores but also, in our experimental conditions, to activate the contractile proteins. This induces an increase in the resting tone that constitutes, the first functional evidence of this Ca2+ entry. 2. The fact that methoxamine (100 microM) reproduces the same processes as noradrenaline but clonidine (1 microM) does not, indicates that alpha(1)-adrenoceptor activation is related to the increase in the resting tone observed after depletion of adrenoceptor-sensitive internal Ca2+-stores. 3. Benoxathian and WB …
Le necropoli di Agrigento: rileggendo alcune immagini dipinte sui vasi
2014
La rilettura delle tematiche figurative di alcuni vasi restituiti dalle necropoli agrigentine lascia intravedere una elite colta della colonia geloa, alimentata dal contesto poltico-culturale costruito nell’Agrigento della tirannide emmenide. Si delinea inoltre un rapporto di ‘committenza’ tra botteghe attiche e aristocrazie coloniali, che scelgono o rifunzionalizzano i soggetti figurativi. Le immagini sono sfruttate per costruire l’identità socio-politica e religiosa di una élite, che con l’età delle tirannidi sembra raffinare il suo modo di autorappresentarsi attraverso l’immaginario mitico, grazie alla vivacità culturale e all’ambiente letterario creatisi attorno alla corte teroniana. Qu…
Propagation of Calendula maritima Guss. (Asteraceae) through Biotechnological Techniques for Possible Usage in Phytotherapy
2022
The genus Calendula (Asteraceae) includes several species that are renowned for their therapeutic properties and/or use as ingredients in the preparation of cosmetics. The rare and critically endangered sea marigold, Calendula maritima Guss., an endemic species from Western Sicily, has also been recognized as a potential “farm plant species” for several important compounds used in cosmetics. However, the few remnant populations of this species are currently threatened with extinction because of several factors, such as hybridization with the congeneric species Calendula suffruticosa subsp. fulgida (Raf.) Guadagno and anthropogenic disturbance of its habitat. Therefore, in order to preserve …
Dos geófitos nuevos para la provincia de Alicante
2018
Se aportan datos sobre dos especies no mencionadas hasta la fecha en la provincia de Alicante, Hyacinthus orientalis y Sternbergia lutea. It is shown some data about two new taxa for the Alicante province, Hyacinthus orientalis and Sternbergia lutea.
Precisiones corológicas y taxonómicas sobre la flora de Alicante
2007
Se presentan datos sobre la distribución y ecología de táxones nuevos o poco conocidos de la flora vascular de Alicante. Se aportan nueve primeras citas concretas para la flora provincial, siendo tres de ellas novedades asimismo para la Comunidad Valenciana. Además, se proponen dos nuevas combinaciones: Nepeta mallophora subsp. bourgaei (Briq.) M.B. Crespo, Camuñas & J.C. Cristóbal, y N. mallophora subsp. anticaria (Ladero & Rivas Goday ex Ubera & Valdés) M.B. Crespo, Camuñas & J.C. Cristóbal. Data are reported on distribution and ecology of new or poorly known taxa of Alicante province (E of Spain). Nine species are cited for the first time in that territory, being three of them also new f…
Acacia cyclops A. Cunn. ex G. Don (Leguminosae) in Italy: first cases of naturalization
2012
The first two cases of naturalization of Acacia cyclops are reported for Italy. Young trees were observed growing in the wild some 15 years ago on Linosa (Pelagie Islands, Strait of Sicily). A decade later, this alien plant should no longer be considered as a casual, since a very intensive process of self-sown regeneration has been observed in some plantations on Lampedusa, the major island of the same Archipelago. The available literature suggests the need for careful monitoring of the ongoing invasion process, as A. cyclops has already shown a very invasive behaviour elsewhere within Mediterranean-type biomes due to its ability to withstand high environmental stresses. As migrating birds …
Effects of Parietaria judaica pollen extract on human microvascular endothelial cells
2008
Abstract Pollinosis from Parietaria judaica is one of the main causes of allergy in the Mediterranean area. The present study is designed to assess if P. judaica pollens contain bioactive compounds able to elicit a functional response in endothelial cells. We have demonstrated that addition of pollen extract to human lung microvascular endothelial cells (HMVEC-L) induces a modification of cell morphology, actin cytoskeletal rearrangements and an increase in endothelial cell permeability. We further showed that the treatment of endothelial cells with pollen extract causes an increase of E-selectin and VCAM-1 protein levels as well as an increase of IL-8 production. The stimulation of cell–ce…
Innovazione e pianificazione. Una nuova visione per il progetto del territorio provinciale
2012
The regional planning, as for a product of synergies arising from differ- ent agents, is getting more and more such a complex topic, possibly requir- ing a renovation in order to refresh its approach. Thinking over how to plan the territory is not a new process. History teaches that both the evolution and the technological progress have always involved some new needs and alterations of the life styles, consequently producing some renovate models as regards the use of the territory. One of the problem, that has urgently to be dealt with, is the relationship between preservation and innovation since the recent models seem to re- gard the territory as a continuously consumable and renewable re…