Search results for " Variation"
showing 10 items of 1712 documents
Genetic architecture of circulating lipid levels
2011
Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independen…
Local and nonlocal weighted pLaplacian evolution equations with Neumann boundary conditions
2011
In this paper we study existence and uniqueness of solutions to the local diffusion equation with Neumann boundary conditions and a bounded nonhomogeneous diffusion coefficient g ≥ 0, {ut = div (g|∇u|p-2∇u) in ]0; T[×Ωg|∇u|p-2u·n = 0 on ]0; T[×∂Ω; for 1 ≤ p < ∞. We show that a nonlocal counterpart of this diffusion problem is ut(t; x)= ∫ω J(x-y)g(x+y/2)|u(t; y)-u(t; x)| p-2 (u(t; y)-u(t; x)) dy in ]0; T[× Ω,where the diffusion coefficient has been reinterpreted by means of the values of g at the point x+y/2 in the integral operator. The fact that g ≥ 0 is allowed to vanish in a set of positive measure involves subtle difficulties, specially in the case p = 1.
A nonlocal p-Laplacian evolution equation with Neumann boundary conditions
2008
In this paper we study the nonlocal p-Laplacian type diffusion equation,ut (t, x) = under(∫, Ω) J (x - y) | u (t, y) - u (t, x) |p - 2 (u (t, y) - u (t, x)) d y . If p > 1, this is the nonlocal analogous problem to the well-known local p-Laplacian evolution equation ut = div (| ∇ u |p - 2 ∇ u) with homogeneous Neumann boundary conditions. We prove existence and uniqueness of a strong solution, and if the kernel J is rescaled in an appropriate way, we show that the solutions to the corresponding nonlocal problems converge strongly in L∞ (0, T ; Lp (Ω)) to the solution of the p-Laplacian with homogeneous Neumann boundary conditions. The extreme case p = 1, that is, the nonlocal analogous t…
NONLOCAL LAYER-WISE ADVANCED THEORIES FOR LAMINATED PLATES
2019
Eringen nonlocal layer-wise models for the analysis of multilayered plates are formulated in the framework of the Carrera Unified Formulation and the Reissner Mixed Variational Theorem (RMVT). The use of the layer-wise approach and RMVT ensures the fulfilment of the transverse stress equilibrium at the layers’ interfaces and allows the analysis of plates with layers exhibiting different characteristic lengths in their nonlocal behaviour. A Navier solution has been implemented and tested for the static bending of rectangular simply-supported plates. The obtained results favourably compare against available three-dimensional analytic results and demonstrate the features of the proposed theori…
Sequence features and evolutionary mechanisms in the chicken avidin gene family
2001
The chicken avidin gene family comprises the avidin gene (avd) and several homologous avidin-related genes (avrs). The sequences of the avr genes are nearly identical to each other but exhibit nonrandomly distributed, frequently nonsynonymous nucleotide substitutions compared to avd. In this study, we determined the genetic distances and the phylogeny of the avd and avr genes and found differences between different exons and introns. Our results suggest the involvement of biased gene conversion in the evolution of the genes. Furthermore, one of the genes was identified as a putative fusion gene. The occurrence of both gene conversion and recombination supports the models suggesting a common…
Emergence and Phylodynamics of Citrus tristeza virus in Sicily, Italy
2013
Citrus tristeza virus (CTV) outbreaks were detected in Sicily island, Italy for the first time in 2002. To gain insight into the evolutionary forces driving the emergence and phylogeography of these CTV populations, we determined and analyzed the nucleotide sequences of the p20 gene from 108 CTV isolates collected from 2002 to 2009. Bayesian phylogenetic analysis revealed that mild and severe CTV isolates belonging to five different clades (lineages) were introduced in Sicily in 2002. Phylogeographic analysis showed that four lineages co-circulated in the main citrus growing area located in Eastern Sicily. However, only one lineage (composed of mild isolates) spread to distant areas of Sici…
Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells
2012
The multidrug resistance-associated protein 2 (MRP2/ABCC2) is involved in the efflux of endogenous and xenobiotic substrates, including several anticancer and antiviral drugs. The functional consequences of ABCC2 protein variants remain inconsistent, which may be due to shortcomings of the in vitro assays used. To study systematically the functional consequences of nonsynonymous ABCC2 variants, we used a novel “Screen and Insert” (ScIn) technology to achieve stable and highly reproducible expression of 13 ABCC2 variants in HT1080 cells. Western blotting revealed lower (30–65%) ABCC2 expression for D333G, R1174H, and R1181L as compared with wild type (WT; 100%), whereas the linked variant V1…
Population genetics of cucumber mosaic virus infecting medicinal, aromatic and ornamental plants from northern Italy
2012
An epidemiological survey carried at the Herb Garden of Casola Valsenio (Emilia Romagna region; Northern Italy) from 2006 to 2009 resulted in finding Cucumber mosaic virus (CMV) as the infectious agent of several ornamental, medicinal and aromatic plants. All CMV-infected plant species showed leaf symptoms followed, in some cases, by flower colour-breaking and stunting. Genetic analysis consisted in the characterization of movement protein gene of each CMV-isolate by single strand polymorphism analysis and sequencing. Phylogenetic trees identified only two isolates as member of subgroup II, while all other isolates were part of subgroup IA. This survey confirms an unexpected increment of CM…
Genetic variability and evolutionary analysis of parietaria mottle virus: role of selection and genetic exchange
2015
[EN] The genetic variability and evolution of parietaria mottle virus (PMoV) of the genus Ilarvirus was studied by analyzing nucleotide sequences of 2b and CP genes from isolates collected in different countries. Phylogenetic analysis showed that PMoV isolates clustered in different clades: one (clade I) composed of only Italian isolates and three clades (clades II-IV) including the Spanish isolates. The Greek isolate GrT-1 used in this study was in clade IV for the CP phylogenetic tree whereas it formed a separate branch in the 2b phylogenetic tree. The nucleotide sequence diversity of both the 2b and CP genes was low (0.062 +/- A 0.006 and 0.063 +/- A 0.006 for 2b and CP, respectively) bu…
Critical point Higgs inflation in the Palatini formulation
2021
We study Higgs inflation in the Palatini formulation with the renormalisation group improved potential in the case when loop corrections generate a feature similar to an inflection point. Assuming that there is a threshold correction for the Higgs quartic coupling $\lambda$ and the top Yukawa coupling $y_t$, we scan the three-dimensional parameter space formed by the two jumps and the non-minimal coupling $\xi$. The spectral index $n_s$ can take any value in the observationally allowed range. The lower limit for the running is $\alpha_s>-3.5\times10^{-3}$, and $\alpha_s$ can be as large as the observational upper limit. Running of the running is small. The tensor-to-scalar ratio is $2.2\tim…