Search results for " adaptive"
showing 10 items of 157 documents
Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis,modulates responses of the human immune system
2017
The selective modulation of immunity is an emerging concept driven by the vast advances in our understanding of this crucial host defense system. Invertebrates have raised researchers’ interest as potential sources of new bioactive molecules owing to their antibacterial, anticancer and immunomodulatory activities. A LipoPolySaccharide (LPS) challenge in the ascidian Ciona intestinalis generates the transcript, Ci8 short, with cisregulatory elements in the 3′ UTR region that are essential for shaping innate immune responses. The derived amino acidic sequence in silico analysis showed specific binding to human Major Histocompatibility Complex (MHC) Class I and Class II alleles. The role of Ci…
Positive selection in development and growth rate regulation genes involved in species divergence of the genus Radix
2015
AbstractBackgroundLife history traits like developmental time, age and size at maturity are directly related to fitness in all organisms and play a major role in adaptive evolution and speciation processes. Comparative genomic or transcriptomic approaches to identify positively selected genes involved in species divergence can help to generate hypotheses on the driving forces behind speciation. Here we use a bottom-up approach to investigate this hypothesis by comparative analysis of orthologous transcripts of four closely related EuropeanRadixspecies.ResultsSnails of the genusRadixoccupy species specific distribution ranges with distinct climatic niches, indicating a potential for natural …
Modelling complex dynamics and distributed generation of knowledge with bacterial-based algorithms
2014
Este estudio tuvo como objetivo demostrar que las sociedades conectadas y heterogéneas con intercambios entre pares (P2P) son más resilientes que las centralizadas y homogéneas. En el modelado basado en agentes, se modelizan agentes con racionalidad limitada que interactúan en un entorno común guiado por reglas locales, lo que lleva a Sistemas Adaptativos Complejos (CAS) que se denominan 'sociedades artificiales'. Estos modelos simplificados de sociedades humanas crecen de abajo hacia arriba en entornos computacionales y pueden utilizarse como un laboratorio para probar algunas hipótesis. Hemos demostrado que en un modelo basado en interacciones libres entre agentes autónomos, los resultado…
Dual Capability EAM for Agility in Business Capability Building : A Systems Theoretical View
2021
Through two cases of IT-enabled business capability building in large enterprises, this paper elucidates how the systems theory approach can explain the enterprise architecture management (EAM) challenge to support business agility. The observation in both of these cases is that a legacy EAM approach does not adapt to a business development scenario involving agility. This leads to a study of the nature of the challenges in EAM when enabling strategic business moves involving new technologies, at the business unit level. For the type of projects as in these cases, we do not find a fitting paradigm in the EAM literature. Suggested solutions are IT bimodality, or Two Speed IT. However, its co…
M-GRASP: A GRASP With Memory for Latency-Aware Partitioning Methods in DVE Systems
2009
A necessary condition for providing quality of service to distributed virtual environments (DVEs) is to provide a system response below a maximum threshold to the client computers. In this sense, latency-aware partitioning methods try to provide response times below the threshold to the maximum number of client computers as possible. These partitioning methods should find an assignment of clients to servers that optimizes system throughput, system latency, and partitioning efficiency. In this paper, we present a new algorithm based on greedy randomized adaptive search procedure with memory for finding the best solutions as possible to this problem. We take into account several different alt…
Modeling a teacher in a tutorial-like system using Learning Automata
2012
Published version of a chapter in the book: Transactions on Computational Collective Intelligence VIII. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-34645-3_2 The goal of this paper is to present a novel approach to model the behavior of a Teacher in a Tutorial- like system. In this model, the Teacher is capable of presenting teaching material from a Socratic-type Domain model via multiple-choice questions. Since this knowledge is stored in the Domain model in chapters with different levels of complexity, the Teacher is able to present learning material of varying degrees of difficulty to the Students. In our model, we propose that the Teacher will be able to as…
A Novel Adaptive Sliding Mode Controller for a 2-DOF Elastic Robotic Arm
2022
Collaborative robots (or cobots) are robots that are capable of safely operating in a shared environment or interacting with humans. In recent years, cobots have become increasingly common. Compliant actuators are critical in the design of cobots. In real applications, this type of actuation system may be able to reduce the amount of damage caused by an unanticipated collision. As a result, elastic joints are expected to outperform stiff joints in complex situations. In this work, the control of a 2-DOF robot arm with elastic actuators is addressed by proposing a two-loop adaptive controller. For the outer control loop, an adaptive sliding mode controller (ASMC) is adopted to deal with unce…
On the accuracy of the fast hierarchical DBEM for the analysis of static and dynamic crack problems
2010
In this paper the main features of a fast dual boundary element method based on the use of hierarchical matrices and iterative solvers are described and its effectiveness for fracture mechanics problems, both in the static and dynamic case, is demonstrated. The fast solver is built by representing the collocation matrix in hierarchical format and by using a preconditioned GMRES for the solution of the algebraic system. The preconditioner is computed in hierarchical format by LU decomposition of a coarse hierarchical representation of the collocation matrix. The method is applied to elastostatic problems and to elastodynamic cases represented in the Laplace transform domain. The application …
Branch and bound for the cutwidth minimization problem
2013
The cutwidth minimization problem consists of finding a linear arrangement of the vertices of a graph where the maximum number of cuts between the edges of the graph and a line separating consecutive vertices is minimized. We first review previous approaches for special classes of graphs, followed by lower bounds and then a linear integer formulation for the general problem. We then propose a branch-and-bound algorithm based on different lower bounds on the cutwidth of partial solutions. Additionally, we introduce a Greedy Randomized Adaptive Search Procedure (GRASP) heuristic to obtain good initial solutions. The combination of the branch-and-bound and GRASP methods results in optimal solu…
E-heutagogy for lifelong e-learning
2012
Abstract The paper aims to introduce a new concept: e-heutagogy. This aim is approached through two sub-objectives:a) Giving the rationale for the new concept of e-heutagogy.b) Outlining the features of e-heutagogy necessary for lifelong e-learning.Why do we need a new concept? Learning is a complex concept and it is a part of our entire life. Today we can speak about new generations of learners at all levels, from kindergarten to university, not only due to technology but also due to rapid changes in open, heterogeneous, dynamic and uncertain environments.Taking into account that heutagogy is appropriate to the needs of learners but learners are most of their life without their teachers an…