Search results for " administration"
showing 10 items of 4299 documents
Comprehensive defence in Latvia – rebranding state defence and call for society's involvement
2020
Abstract This article explores how comprehensive defence has been introduced in Latvia, and focuses on society's involvement and tasks in the state defence. This approach envisages a significant change in society's relationship with the armed forces and state defence. Differently from many other countries, Latvia maintains its system without introducing conscription and instead puts efforts towards youth education in defence. Additionally, the Ministry of Defence involves different society groups and NGOs in defining their role in state defence. This article also discusses the concepts of resistance and non-collaboration as part of comprehensive defence.
Introduction: Research Interest and Research Questions
2017
This chapter explores the theoretical and empirical puzzles of regionalism in the Global South on the example of the Southern African Development Community (SADC). The SADC is one of the most realistic and promising examples of the new regionalism and shows constant dynamics in a number of policy areas. The main research interest of this much-needed analysis is to explain the emergence, institutional design and performance of regionalism in the SADC from a political science perspective. In order to provide innovative research, the analytical focus is on the role and influence of regional key countries and, particularly, external actors. Moreover, this chapter offers a comprehensive overview…
Backlash against the procedural consensus
2020
While the politics of backlash is typically described as a reaction to policy decisions in favour of minority rights, immigration or globalisation, this essay focuses on the fact that backlash typically also involves a reaction against the procedural consensus liberal democracy is based upon. This challenge to democratic procedures and institutions may be even more dangerous in its effects than the substantial objectives of backlash. I use the composite definition of backlash suggested by Alter and Zürn to assess in how far the attacks on the institutions of liberal democracy have retrograde objectives in themselves or in how far they are merely instrumental to the pursuit of other retrogr…
The “Refugee Crisis,” Immigration Attitudes, and Euroscepticism
2019
Between 2015 and 2017, the European Union (EU) was confronted with a major crisis in its history, the so-called “European refugee crisis.” Since the multifaceted crisis has provoked many different responses, it is also likely to have influenced individuals’ assessments of immigrants and European integration. Using data from three waves of the European Social Survey (ESS) — the wave before the crisis in 2012, the wave at the beginning of the crisis in 2014, and the wave right after the (perceived) height of the crisis in 2016 — we test the degree to which the European refugee crisis increased Europeans’ anti-immigrant sentiment and Euroscepticism, as well as the influence of Europeans’ anti-…
From “Mano Dura” to “Enfrentamiento Directo”: swings of public policies in El Salvador
2019
RESUMEN Introduccion: El presente trabajo analiza las cuatro principales politicas publicas de seguridad contra las pandillas en El Salvador: Mano Dura (2003-2004), Super Mano Dura (2004-2009), Tregua entre pandillas (2012-2014) y Enfrentamiento Directo (2014-2019). El objetivo es identificar la influencia de estas politicas sobre la violencia. Materiales y Metodos: Se trata de una investigacion cualitativa apoyada en 12 entrevistas y el relato de vida con las que se explora la responsabilidad gubernamental frente al problema de la violencia en El Salvador. El trabajo de campo se efectuo durante 7 meses, entre septiembre de 2016 y marzo de 2017. El tratamiento de la informacion se efectuo m…
La performance hospitalière : à la recherche d'un modèle multidimensionnel cohérent
2009
Cet article a pour ambition de proposer un modele multidimensionnel coherent de la performance hospitaliere. En effet, le secteur hospitalier doit repondre a une performance globale et multidimensionnelle (qualite et securite des soins, utilisation optimale des ressources, productivite, satisfaction du patient, etc.). En France, aucun modele integrant les differentes dimensions de la performance hospitaliere n’a pour l’instant ete instaure alors que l’hopital public est au centre d’enjeux essentiels pour son avenir. Pour construire ce modele, nous nous appuierons d’une part sur une comparaison des systemes hospitaliers de trois pays anglo-saxons et d’autre part, sur une revue des cadres con…
FLT3 Ligand as a Molecular Adjuvant for Naked RNA Vaccines
2016
Intranodal immunization with antigen-encoding naked mRNA has proven to be an efficacious and safe approach to induce antitumor immunity. Thanks to its unique characteristics, mRNA can act not only as a source for antigen but also as an adjuvant for activation of the immune system. The search for additional adjuvants that can be combined with mRNA to further improve the potency of the immunization revealed Fms-like tyrosine kinase 3 (FLT3) ligand as a potent candidate. Systemic administration of the dendritic cell-activating FLT3 ligand prior to or along with mRNA immunization-enhanced priming and expansion of antigen-specific CD8(+) T cells in lymphoid organs, T-cell homing into melanoma tu…
Consensus paper on the “executive summary of the international conference on Mediterranean diet and health: a lifelong approach” an Italian initiativ…
2018
The Mediterranean Diet Foundation, in collaboration with the International Menarini Foundation, organized the “International Conference on Mediterranean Diet and Health: A Lifelong Approach.” The Conference was held in Ostuni (Puglia, Italy) from March 30 to April 1, 2017. The event received the endorsement of the American Federation for Aging Research, the Research Consortium “Luigi Amaducci,” the European Nutrition for Health Alliance, the European Union Geriatric Medicine Society, the Clinical Section of the International Association of Gerontology and Geriatrics—European Region, the National Research Council Research Project on Aging, the Italian Society of Gerontology and Geriatrics, a…
Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model
2017
The therapy of inflammatory bowel diseases is still rather inefficient, and about 80% of patients require surgery at some stage. Improving the treatments by more efficient medication is, therefore, an urgent medical need. The objective of this project was to demonstrate targeted delivery of Cyclosporine-A (CYA) to the inflamed areas of the intestinal mucosa after oral administration, enabling improved alleviation of the symptoms and, at the same time, reduced systemic drug absorption and associated adverse effects. As had already been demonstrated in previous studies, nano- to micrometer-sized drug particles will accumulate at inflamed mucosal areas, providing a platform for such purposes. …
Oral Monosodium Glutamate Administration Causes Early Onset of Alzheimer's Disease-Like Pathophysiology in APP/PS1 Mice.
2019
Glutamate excitotoxicity has long been related to Alzheimer's disease (AD) pathophysiology, and it has been shown to affect the major AD-related hallmarks, amyloid-β peptide (Aβ) accumulation and tau phosphorylation (p-tau). We investigated whether oral administration of monosodium glutamate (MSG) has effects in a murine model of AD, the double transgenic mice APP/PS1. We found that AD pathogenic factors appear earlier in APP/PS1 when supplemented with MSG, while wildtype mice were essentially not affected. Aβ and p-tau levels were increased in the hippocampus in young APP/PS1 animals upon MSG administration. This was correlated with increased Cdk5-p25 levels. Furthermore, in these mice, we…