Search results for " aging."
showing 10 items of 556 documents
Female Vascular Senescence
2012
Long before the existence of cardiovascular imaging, Sir William Osler axiom that “man is as old as his arteries”. Followed by several physicians for decades, this aphorism has been widely confirmed by studies demonstrating that risk factors for cardiovascular disease increase as we age (Cooper et al., 1994; Lakatta & Levy, 2003). Nevertheless, a flaw in this statement is the generalization that men and women age similarly. Much data from clinical and basic research have established that vascular aging in women does not follow the same chronology as in men (Shaw et al., 2006; Pereira et al., 2010; Takenouchi et al., 2009). If known risk factors that influence cardiovascular aging are exclud…
Genetic manipulation of longevity-related genes as a tool to regulate yeast life span and metabolite production during winemaking
2013
Abstract Background Yeast viability and vitality are essential for different industrial processes where the yeast Saccharomyces cerevisiae is used as a biotechnological tool. Therefore, the decline of yeast biological functions during aging may compromise their successful biotechnological use. Life span is controlled by a variety of molecular mechanisms, many of which are connected to stress tolerance and genomic stability, although the metabolic status of a cell has proven a main factor affecting its longevity. Acetic acid and ethanol accumulation shorten chronological life span (CLS), while glycerol extends it. Results Different age-related gene classes have been modified by deletion or o…
Functional capacity and risk of frailty syndrome in 85-year-old and older women living in nursing homes in Poland
2021
Maintaining sufficient physical fitness to prevent any limitations in performing activities of daily living and to be functionally independent is of great importance for both longevity and quality of life in older adults. Aim of the study was to evaluate functional physical fitness of women aged 85 years and older, residents of nursing homes, in the Polish population and to assess the risk of frailty syndrome. The study involved 17 women aged 85 years or older, residents of nursing homes in the Lower Silesian voivodeship. The Senior Fitness Test was used to assess functional fitness. The results of functional fitness tests were related to the standards for the elderly population in Poland a…
Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long‐lived individuals
2022
The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represen…
Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
2023
Many neurodegenerative disorders are characterized by the abnormal aggregation of misfolded proteins that form amyloid deposits which possess prion-like behavior such as self-replication, intercellular transmission, and consequent induction of native forms of the same protein in surrounding cells. The distribution of the accumulated proteins and their correlated toxicity seem to be involved in the progression of nervous system degeneration. Molecular chaperones are known to maintain proteostasis, contribute to protein refolding to protect their function, and eliminate fatally misfolded proteins, prohibiting harmful effects. However, chaperone network efficiency declines during aging, prompt…
Les expertises dans le domaine du vin : cas du concept de vin de garde
2010
Wine expertise : the case of "vin de garde" concept. This work aimed to investigate different types of knowledge and skills involved in wine expertise. This work is based on the “vin de garde” concept, we first broadened the study of this concept, and we identified gustatory (astringency and acidity) and olfactory (woody, burnt, vanilla and prune notes) clues used by wine professionals from Bourgogne to judge the aging potential of red wines from Bourgogne. The expertise is investigated through two studies. In the first study, we examined if the environment in which professionals practise leads to specific perceptive skills and conceptual knowledge regarding wines with an aging potential. W…
In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellul…
2017
Obesity, metabolic syndrome, and hyperleptinemia are associated with aging and age-associated diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increases insulin sensitivity and suppresses prostate cancer cell tumor growth in animal models, providing a rationale for clinical trials. We sought to demonstrate that biomarkers derived from plasma extracellular vesicles (EVs) reflect systemic leptin and insulin signaling and respond to dietary interventions. We studied plasma samples from men with prostate cancer awaiting prostatectomy who particip…
Cross-Sectional and Longitudinal Associations between Leisure Time Physical Activity, Mental Well-Being and Subjective Health in Middle Adulthood
2019
Previous studies have shown that participation in leisure time physical activity is related to better mental well-being and subjective health. However, the associations between different types of leisure time physical activities and different dimensions of mental well-being have rarely been studied. In addition, longitudinal research, analyzing possible causal relations between these variables, is lacking. To investigate these research questions, data gathered at ages 42 and 50 (present N = 303) for the Finnish Jyväskylä Longitudinal Study of Personality and Social Development were used. Physical activity was assessed as frequency of participation at ages 42 and 50, and at age 50 also as fr…
Los Centros Especializados de Atención a Mayores (CEAM) en la Comunidad Valenciana: un modelo de prevención gerontológica
2010
Concepto y características de un Centro Especializado de Atención a Mayores. Evolución histórica de los centros de mayores, sus áreas de intervención y programas que se desarrollan en los CEAMs. Envejecimiento activo en los CEAM. Conclusiones Specialized elder care center: concept and characteristics. Historical evolution of centers for senior citizens. Intervention areas and programs developed at CEAM. Active aging at CEAM. Conclusions.
Iedzīvotāju skaita samazināšanās un jauniešu emigrācija Latvijā un Lietuvā
2018
Maģistra darba mērķis ir aprakstīt un analizēt demogrāfiskās tendences iedzīvotāju migrācijā, novecošanā, populācijas sarukšanā, intelektuālā darbaspēka emigrācijā un izvērtēt šos kritērijus Lietuvā un Latvijā. Kādas ir dažādo demogrāfisko parādību definīcijas un to atšķirības un kā tās tiek pielietotas Lietuvā un Latvijā salīdzinājumā ar pārējo pasauli un Eiropas Savienību? Un kāda ir Lietuvas un Latvijas jaunatnes motivācija dzīvot, strādāt un veidot ģimenes savā dzimtenē? Ko veicina augsts negatīvās migrācijas, iedzīvotāju skaita samazināšanās un novecošanas rādītājs Lietuvā un Latvijā un kāpēc tas ir tik svarīgs jautājums? Darbā tiks analizēti notikumi no 90. gadu sākuma līdz mūsdienām …