Search results for " aging."
showing 10 items of 556 documents
Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders
2010
In recent years there has been a growing interest, supported by a large number of experimental and epidemiological studies, in the beneficial effects of some commonly used food-derived products in preventing various age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. Spices and herbs often contain active phenolic substances endowed with potent antioxidative and chemopreventive properties. Curcumin is a phytochemical compound extracted from the rhizome of Curcuma Longa. It is the pigment responsible for the characteristic yellow color of Indian curry. Data from our and other laboratories demonstrated that curcumin, as well as some other polyphenols, strongly…
The Impact of Population Ageing and Social Stratification: The Case of Latvia
2019
Population ageing and social stratification is widely assumed to have detrimental effects on the economy yet there is little empirical evidence about the magnitude of its effects. The aim of this article is to investigate the relationships between population ageing and social stratification and the state of economy of a small and post-transition economy. We are looking for these relationships and their strength of influence; at what time after shocking these variables reach their original levels. We apply standard Granger (non-) causality tests, VAR (Vector Auto-Regressive), IRF (Impulse Response Function) and the prediction error variance analysis by using quarterly data from 2000 to 2018.…
Depopulation in the Baltic states
2011
Šiame straispnyje nagrinėjami pagrindiniai Baltijos šalyse vykstančių demografinių procesų bruožai. Atkūrus nepriklausomybę Estijoje, Latvijoje ir Lietuvoje išryškėjo gyventojų skaičiaus mažėjimo tendencija, kurią nulėmė neigiama natūrali gyventojų kaita ir neigiama neto tarptautinė migracija (išvykusiųjų skaičius viršija atvykusiųjų skaičių). Kartų kaitos neužtikrinantis gimstamumo lygis, santykinai aukštas mirtingumo lygis (ypač vyrų), intensyvi emigracija ir gyventojų senėjimas stebimi visose Baltijos šalyse. Šios nepalankios tendencijos ypač pasireiškė šalims įstojus į Europos Sąjungą 2004 m. Nuo 1990 m. Latvija ir Lietuva pasižymi vienais iš didžiausių depopuliacijos tempų Europoje. De…
Low in vivo brain glucose consumption and high oxidative stress in accelerated aging
2009
AbstractThe validity of the free radical theory of aging has been recently questioned. Our aim was to test whether there is oxidative stress in tissues critically involved in accelerated aging (senescence-accelerated mice, SAM) and whether this correlates with lower glucose consumption in vivo and behavioural tests. Positron emission tomography shows that brains of old SAM-prone animals consume less glucose than young ones. Behavioural characteristics, mitochondrial peroxide production, and damage in both the central nervous system and bone marrow stem cells also indicate that SAM-prone animals age faster than SAM-resistant ones. Our results support the role of the free radical theory of ag…
Prevalence and characteristics of prisoners requiring end-of-life care: A prospective national survey
2017
Background: Ensuring adequate end-of-life care for prisoners is a critical issue. In France, data investigating the impact of laws allowing release of seriously ill prisoners are lacking. Aim: To assess the number and characteristics of prisoners requiring palliative care in French prisons. Design: A prospective, national survey collecting data over a 3-month period. Setting/participants: All healthcare units ( n = 190) providing care for prisoners in France. The prison population was 66,698 during the study period. Data collection concerned prisoners requiring end-of-life care, that is, with serious, advanced, progressive, or terminal illness and life expectancy <1 year. Results: Estima…
Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators
2021
The vast majority of the literature on the aryl hydrocarbon receptor is concerned with its functions in xenobiotic detoxification. However, in the course of evolution, this receptor had to have physiological (rather than toxicological) functions. Our aim was to review the aryl hydrocarbon receptor’s role in the physiological functions involved in aging. This study was performed by searching the MEDLINE and Google Academic databases. A total of 34 articles were selected that focused specifically on the aryl hydrocarbon receptor and aging, the aryl hydrocarbon receptor and physiological functions, and the combination of both. This receptor’s main physiological functions (mediated by the modul…
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases
2020
Abstract Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress‐induced and aging‐related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine‐immune system, which explain their traditional use for the treatment of a wide range of conditions. They exhibit a biphasic dose‐effect response: at low doses they function as …
Oxidative stress and mitochondrial dysfunction in Kindler syndrome
2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.
The effect of Transient over Voltages on the Partial Discharges activity in HVDC joints
2021
Rapid growth of HVDC cable line installations is expected in the coming years. Several research groups have investigated dielectric phenomena that occur in the insulation of HVDC cables and accessories that accelerate aging and reduce the reliability of this technology over time. Unlike in HVAC cables, under HVDC stress, the distribution of the electric field inside the insulation layer depends not only on the applied voltage but also on the temperature distribution and on other factors related to manufacturing such as the presence of impurities. Reaching local and transient electric field peaks can enhance the onset of Partial Discharges (PDs) which can lead to premature aging of the insul…
Release and permeation profiles of spray-dried chitosan microparticles containing caffeic acid
2018
Made available in DSpace on 2018-12-11T17:17:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01 Caffeic acid (CA), a phenolic compound found in plants with antioxidant and antimicrobial activity, induces collagen production and prevents premature aging of the skin. The objective of this study was to develop two types of chitosan microparticles (MP) containing CA and to relate the morphology with the release and permeation profiles. One type of MP was prepared from a hydroalcoholic solution (MPI) and the other from an aqueous solution (MPII). Their morphology and size was evaluated by high-resolution scanning electron microscopy. The release profile of CA was evaluated using the…