Search results for " antibiotics"

showing 10 items of 50 documents

Determination of several aminoglycoside and macrolide antibiotics in animal tissues by liquid chromatography-electrospray ionization-tandem mass spec…

2008

ChromatographyLiquid chromatography electrospray ionization tandem mass spectrometryProtein mass spectrometryLiquid chromatography–mass spectrometrymedicine.drug_classChemistryAminoglycosidemedicineGeneral MedicineToxicologySample preparation in mass spectrometryMacrolide AntibioticsToxicology Letters
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Pathophysiology of anthracycline cardiotoxicity.

2016

Anthracyclines (ANTs) are powerful drugs that have reduced the mortality of cancer patients. However, their use is limited by the development of cardiotoxicity (CTX), which is dose dependent and may lead to left ventricular dysfunction and heart failure. Although various strategies have been suggested to reduce the negative effects of ANTs, CTX is still an important unresolved clinical issue. This may be due at least partly to the incomplete characterization of the molecular and cellular mechanisms of ANT-induced CTX. In addition, although various forms of cardiac damage have been demonstrated with the use of these drugs in experimental studies, it is not yet clear how these translate to th…

DrugAnthracyclinemedia_common.quotation_subjectLeftanthracyclines; cancer; cardiotoxicity; Cardiology and Cardiovascular MedicineDose dependenceAntineoplastic Agents030204 cardiovascular system & hematologyanthracyclineBioinformatics03 medical and health sciencesVentricular Dysfunction Left0302 clinical medicineAntibioticsNeoplasmsVentricular DysfunctionmedicinecancerHumansGenetic Predisposition to DiseaseAnthracyclinesmedia_commonHeart FailureCardiotoxicityAntibiotics AntineoplasticDose-Response Relationship Drugbusiness.industryanthracyclines cancer cardiotoxicityCancerHeartGeneral Medicinebiochemical phenomena metabolism and nutritionmedicine.diseaseAntineoplasticPathophysiologyCardiotoxicityCardiovascular Diseases030220 oncology & carcinogenesisHeart failureCardiology and Cardiovascular Medicinebusinessanthracyclines; cancer; cardiotoxicity; Anthracyclines; Antibiotics Antineoplastic; Cardiotoxicity; Heart Failure; Humans; Neoplasms; Ventricular Dysfunction LeftJournal of cardiovascular medicine (Hagerstown, Md.)
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Photo-induced fluorescence of magnesium derivatives of tetracycline antibiotics in wastewater samples

2009

Abstract An analytical strategy, for the determination of tetracyclines (TCs), based on a HPLC system coupled with a photo-reactor followed by post-column derivatization was developed. Higher fluorescence emission after coupling the resulting photo-fragments with magnesium ions was observed for the determination of minocycline (MC), epitetracycline (ETC), tetracycline (TC) and doxycycline (DC). The manifold included a HPLC system with a photo-reactor (PTFE tubing helically coiled around a low-pressure mercury lamp), a mixing T-piece and a fluorescence detector. The derivatization reagent was delivered at 0.5 mL min −1 by a pump. After HPLC separation using a gradient system with a mobile ph…

Environmental EngineeringLightPhotochemistrymedicine.drug_classHealth Toxicology and MutagenesisTetracycline antibioticsMagnesium Compoundschemistry.chemical_elementWaste Disposal FluidHigh-performance liquid chromatographyFluorescenceFluorescence spectroscopychemistry.chemical_compoundmedicineEnvironmental ChemistrySolid phase extractionDerivatizationWaste Management and DisposalMagnesium ionChromatography High Pressure LiquidChromatographyMagnesiumReproducibility of ResultsReference StandardsPollutionchemistryTetracyclinesReagentIndicators and ReagentsWater Pollutants ChemicalJournal of Hazardous Materials
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VIRULENCE FACTORS AND ANTIMICROBIAL RESISTANCE OF ESCHERICHIA COLI ST131 IN COMMUNITY-ONSET HEALTHCARE-ASSOCIATED INFECTIONS IN SICILY, ITALY

2017

Escherichia coli ST131 is an emerging resistant agent recently called “superbug” in England. This strain is responsible of community-acquired urinary tract infections and nowadays showing increasing resistance to antibiotics like fluoroquinolones and cephalosporins. Survey of virulent bacterial clone is relevant to control its spreading in community. We aim to assess the circulation of resistant clones Escherichia coli ST131 outside of the hospital to prompt control of outbreak in our geographical area. We selected 105 E. coli resistant isolates from community-acquired urinary infections and performed a multiplex PCR to evaluate if they belonged to the ST131 type. We investigated their set …

Escherichia coli urinary tract infections antibiotics fluoroquinolones cephalosporins
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A 3-week post-weaning restricted feeding as alternative to an ad libitum antibiotic-medicated feed: Effects on growth, carcass and meat of rabbits di…

2022

In this investigation, the impact of a 3-week post-weaning restricted feeding (RF) using an antibiotic-free feed, applied to rabbits from 36 to 56 days of age to preserve their health status as alternative to an ad libitum medicated feed with antibiotics (AMF), was verify in relation to rabbit genotype and slaughter age (SA). The RF and AMF treatments were compared evaluating their effects on feed intake, growth, mortality, carcass and meat quality of rabbits of two genotypes, Italian White purebred (IWP) and hybrid Hycole×IWP crossbred (HIWC), slaughtered at 78 or 92 days of age to obtain light or heavy carcasses. At 36 days of age, 256 weaned rabbits of both sexes were divided into 4 homo…

General VeterinaryFeed restriction Antibiotics Crossbred rabbits Feed conversion ratio Rabbit mortality rateAnimal Science and ZoologyLivestock Science
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Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia

2018

Background and objectives: Many pediatric patients have been treated with antibiotics during their hospitalization. There is a need to improve antibiotic prescribing for pediatric patients because many of these prescriptions are inappropriate. Antibiotic consumption analysis was conducted at the Children&rsquo

Hospitals CountyMale0301 basic medicinePoint prevalence surveymedicine.medical_specialtyMedicine (General)Adolescentmedicine.drug_class030106 microbiologyAntibioticsInappropriate Prescribingparenteral antibioticsArticlepoint prevalence surveyHospitals UniversityTertiary Care CentersAntimicrobial Stewardship03 medical and health sciences0302 clinical medicineR5-920defined daily dose; hospitalized children; parenteral antibiotics; point prevalence survey; third-generation cephalosporinsInternal medicinemedicineHumans030212 general & internal medicineMedical prescriptionChilddefined daily dosebusiness.industryData CollectionCeftriaxoneDrug Resistance MicrobialGeneral MedicineAmoxicillinHospitals PediatricUniversity hospitalLatviaDrug UtilizationAnti-Bacterial Agentsthird-generation cephalosporinsCross-Sectional StudiesDefined daily doseChild PreschoolCeftriaxonehospitalized childrenFemaleObservational studybusinessmedicine.drugMedicina; Volume 54; Issue 5; Pages: 74
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Idiopathic facial aseptic granuloma.

2014

Summary Idiopathic facial aseptic granuloma (IFAG) is a condition that is commonly encountered in clinical practice, but is rarely reported. It appears in childhood and its pathogenesis is still unknown. It has a benign course with resolution within a few months without aggressive treatment. Microbiological tests are negative and histological findings are nonspecific. It is possible that this condition is part of the spectrum of granulomatous rosacea in childhood. We present two cases in which diagnosis of IFAG was established and resolved without sequelae following topical antibiotic treatment.

Idiopathic facial aseptic granulomaMalemedicine.medical_specialtyGranulomaGranulomatous RosaceaAdolescentbusiness.industryTopical antibioticsDermatologymedicine.diseaseSurgeryPathogenesisClinical PracticeDiagnosis DifferentialRosaceamedicineHumansFemalebusinessChildFacial DermatosesClinical and experimental dermatology
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Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

2019

Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early pr…

Male:Medicina Básica [Ciências Médicas]030230 surgeryLogistic regression0302 clinical medicineInjury Severity ScoreInterquartile rangeRisk FactorsAntibioticsAbdomenDiagnosisAcute peritonitis; Early warning score; Emergency surgery; Source control; Abdomen; Adult; Aged; Chi-Square Distribution; Female; Hospital Mortality; Humans; Injury Severity Score; Logistic Models; Male; Middle Aged; Risk Factors; Sepsis; PrognosisHospital MortalityMortality rateAcute peritonitilcsh:Medical emergencies. Critical care. Intensive care. First aidaarly warning scoreAcute peritonitisMiddle AgedEarly warning scorePrognosisacute peritonitis; aarly warning score; emergency surgery; source control; abdomen; adult; aged; chi-square distribution; female; hospital mortality; humans; injury severity score; logistic models; male; middle aged; risk factors; sepsis; prognosis3. Good healthManagementCiências Médicas::Medicina BásicaEmergency MedicineEmergency surgeryInjury Severity ScoreFemaleResearch ArticleHumanAdultmedicine.medical_specialtyLogistic ModelSepsilcsh:SurgeryNO03 medical and health sciencesSource controlInternal medicineSepsismedicineHumansAgedAcute appendicitisScience & TechnologyChi-Square Distributionbusiness.industryAcute peritonitis; Early warning score; Emergency surgery; Source controlRisk FactorAcute appendicitis; Antibiotics; Diagnosis; Management; SurgeryEarly warning scorelcsh:RD1-811lcsh:RC86-88.93126 Surgery anesthesiology intensive care radiologymedicine.diseaseAcute peritonitis ; Early warning score ; Emergency surgery ; Source controlLogistic ModelsObservational studySurgerybusinessChi-squared distributionKidney disease
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Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

2018

Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments.

Male:Medicina Básica [Ciências Médicas]Computed tomography030230 surgery0302 clinical medicineAntibioticsDiagnosisAppendicitiProspective StudiesLaparoscopyProspective cohort studyTomographymedicine.diagnostic_testAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Surgery; Emergency MedicineAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Acute Disease; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Female; Hospitalization; Humans; Laparoscopy; Length of Stay; Logistic Models; Male; Prospective Studies; Tomography X-Ray Computed; Treatment OutcomeMortality ratelcsh:Medical emergencies. Critical care. Intensive care. First aidApendicite3. Good healthX-Ray ComputedManagementHospitalizationTreatment Outcome030220 oncology & carcinogenesisCiências Médicas::Medicina BásicaAcute appendicitisAcute DiseaseEmergency MedicineFemaleAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Acute Disease; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Female; Hospitalization; Humans; Laparoscopy; Length of Stay; Logistic Models; Male; Prospective Studies; Tomography X-Ray Computed; Treatment Outcome; Surgery; Emergency MedicineDiagnosiHumanResearch ArticleAdultmedicine.medical_specialtyLogistic Modellcsh:SurgeryNO03 medical and health sciencesmedicineAppendectomyHumansAcute appendicitisChi-Square Distributionbusiness.industryGeneral surgeryAntibioticAcute appendicitis; Antibiotics; Diagnosis; Management; Surgerylcsh:RD1-811lcsh:RC86-88.9Length of Staymedicine.diseaseAppendicitisAppendicitisProspective StudieLogistic ModelsObservational studyLaparoscopySurgeryAcute appendicitibusinessTomography X-Ray ComputedChi-squared distributionWorld Journal of Emergency Surgery
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Adherence to antibiotic treatment guidelines and outcomes in the hospitalized elderly with different types of pneumonia.

2015

none 22 no Background: Few studies evaluated the clinical outcomes of Community Acquired Pneumonia (CAP), Hospital-Acquired Pneumonia (HAP) and Health Care-Associated Pneumonia (HCAP) in relation to the adherence of antibiotic treatment to the guidelines of the Infectious Diseases Society of America (IDSA) and the American Thoracic Society (ATS) in hospitalized elderly people (65 years or older). Methods: Data were obtained from REPOSI, a prospective registry held in 87 Italian internal medicine and geriatric wards. Patients with a diagnosis of pneumonia (ICD-9 480-487) or prescribed with an antibiotic for pneumonia as indication were selected. The empirical antibiotic regimen was defined t…

MaleAntibiotic regimenGuidelines adherenceSettore MED/09 - Medicina InternaAntibioticsLogistic regressionElderlyCommunity-acquired pneumoniaAntibiotics80 and overElderly peopleAge FactorHospital MortalityAged 80 and overTreatment regimenMedicine (all)Age FactorsOptimal managementAntibiotics; Elderly; Guidelines adherence; Mortality; Pneumonia; Re-hospitalization; Age Factors; Aged; Aged 80 and over; Anti-Bacterial Agents; Female; Hospital Mortality; Humans; Logistic Models; Male; Pneumonia; Practice Guidelines as Topic; Treatment Outcome; Guideline Adherence; Hospitalization; Internal Medicine; Medicine (all)Anti-Bacterial AgentsHospitalizationTreatment OutcomePractice Guidelines as TopicFemaleGuideline AdherenceHumanmedicine.medical_specialtyLogistic Modelmedicine.drug_classSocio-culturaleantibiotic treatment; guidelines; pneumonia; elderly;Internal medicineRe-hospitalizationAnti-Bacterial AgentmedicineInternal MedicineHumanselderly pmeumonia antibiotics guidelines adherence mortality re-hospitalizationpmeumoniaMortalityIntensive care medicineAntibiotics; Elderly; Guidelines adherence; Mortality; Pneumonia; Re-hospitalization; Age Factors; Aged; Aged 80 and over; Anti-Bacterial Agents; Female; Hospital Mortality; Humans; Logistic Models; Male; Pneumonia; Practice Guidelines as Topic; Treatment Outcome; Guideline Adherence; Hospitalization; Internal MedicineAgedbusiness.industrySettore MED/09 - MEDICINA INTERNAAntibioticPneumoniamedicine.diseasePneumoniaAntibiotics; Elderly; Guidelines adherence; Mortality; Pneumonia; Re-hospitalizationLogistic ModelsAntibiotics; Elderly; Guidelines adherence; Mortality; Pneumonia; Re-hospitalization; Age Factors; Aged; Aged 80 and over; Anti-Bacterial Agents; Female; Hospital Mortality; Humans; Logistic Models; Male; Pneumonia; Practice Guidelines as Topic; Treatment Outcome; Guideline Adherence; Hospitalizationbusiness
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