Search results for " bone"
showing 10 items of 933 documents
The comparison of knee osteoarthritis treatment with single-dose bone marrow-derived mononuclear cells vs. hyaluronic acid injections
2017
Objective: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. Materials and methods: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren– Lawrence stage II–III osteoarthritis during the 12-month period were performed. The results were compared with the control group treated routinely by hyaluronic acid injections…
Characterization of C4-2 Prostate Cancer Bone Metastases and Their Response to Castration
2003
New well-characterized preclinical models of prostate cancer (CaP) bone metastases are needed to improve our understanding of the development of CaP-related bone disease in patients. Here we describe characterization of a model consisting of direct injection of C4–2 cells into tibias. Introduction: Prostate cancer (CaP) has a high proclivity to metastasize to bone. Development and characterization of preclinical models of CaP bone metastases are of high interest. The objective of this study was to characterize C4–2 bone metastases and their response to castration. Materials and Methods: Cell suspensions of C4-2, a subline of LNCaP, were injected directly into the tibias of intact male mice.…
Is there a role for percutaneous pelvic and acetabular reconstruction?
2007
The primary goal in the treatment of pelvic fractures is the restoration of haemodynamic stability. The secondary goal is the reconstruction of stability and symmetry of the pelvic ring. Percutaneous reconstruction can only be accepted if these goals are met. The type of definitive surgery is dependent of the degree of instability of the anterior and posterior pelvic ring. Retrograde transpubic screw fixation of pubic rami fractures is a good alternative to external fixation or plate and screw osteosynthesis. The technique of screw placement and image intensifier control is explained. Internal fixation of pure sacroiliac dislocations, fracture-dislocations of the sacroiliac joint and sacral…
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium
2011
Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of RO…
Enregistrement du cycle du carbone au Pliensbachien (Jurassique inférieur) sur la marge sud téthysienne (Amellago, Haut-Atlas Central, Maroc)
2018
International audience; Le Pliensbachien s’inscrit dans un contexte climatique greenhouse au Jurassique, en période de dislocation de la Pangée. De récentes études dans le domaine nord-ouest téthysien ont démontré une certaine variabilité climatique soutenue notamment par des variations isotopiques remarquables dans le cycle du carbone, comparables en amplitude et en durée à d’autres événements du Toarcien (e.g. T-OAE). Malgré la multiplication des travaux le long de la marge nord téthysienne avec la mise en évidence de changements géodynamiques importants, la marge sud n’a jamais été étudiée à haute résolution. Nous proposons, dans un cadre biostratigraphique extrêmement précis (ammonites …
Photo-acoustic excitation and optical detection of fundamental flexural guided wave in coated bone phantoms.
2013
Abstract Photo-acoustic (PA) imaging was combined with skeletal quantitative ultrasound (QUS) for assessment of human long bones. This approach permitted low-frequency excitation and detection of ultrasound so as to efficiently receive the thickness-sensitive fundamental flexural guided wave (FFGW) through a coating of soft tissue. The method was tested on seven axisymmetric bone phantoms, whose 1- to 5-mm wall thickness and 16-mm diameter mimicked those of the human radius. Phantoms were made of a composite material and coated with a 2.5- to 7.5-mm layer of soft material that mimicked soft tissue. Ultrasound was excited with a pulsed Nd:YAG laser at 1064-nm wavelength and received on the s…
Assessment of the cortical bone thickness using ultrasonic guided waves: Modelling and in vitro study
2007
Determination of cortical bone thickness is warranted, e.g., for assessing the level of endosteal resorption in osteoporosis or other bone pathologies. We have shown previously that the velocity of the fundamental antisymmetric (or flexural) guided wave, measured for bone phantoms and bones in vitro, correlates with the cortical thickness significantly better than those by other axial ultrasound methods. In addition, we have introduced an inversion scheme based on guided wave theory, group velocity filtering and 2-D fast Fourier transform, for determination of cortical thickness from the measured velocity of guided waves. In this study, the method was validated for tubular structures by usi…
Thickness sensitivity of ultrasound velocity in long bone phantoms
2004
One approach to bone disease diagnosis such as osteoporosis is to measure the velocity of ultrasound propagating axially along long bones. In this study, the variation in velocity as a function of radial position was assessed using two polyvinyl chloride (PVC) bone phantoms with cross-sectional geometry similar to the human tibia but differing in medullary cavity diameter. Two ultrasonometers were used: these were a commercial device operating at a relatively high frequency (HF) of 1.25 MHz and a prototype low frequency (LF) device operating at approximately 200 kHz. The LF measurements showed a larger variation with radial position, with changes in velocity of up to 20% occurring around th…
Measuring guided waves in long bones: Modeling and experiments in free and immersed plates
2005
Guided waves, consistent with the A0 Lamb mode, have previously been observed in bone phantoms and human long bones. Reported velocity measurements relied on line fitting of the observed wave fronts. Such an approach has limited ability to assess dispersion and is affected by interference by other wave modes. For a more robust identification of modes and determination of phase velocities, signal processing techniques using the fast Fourier transform (FFT) were investigated. The limitations of FFT because of spatial resolution were addressed to improve the precision of the measured modes. An inversion scheme was developed for determining the plate thickness from the measured velocity. Experi…
Osseointegration of one-piece zirconia implants compared with a titanium implant of identical design: a histomorphometric study in the dog
2010
Objective: The aim of this study was to evaluate osseointegration of one-piece zirconia vs. titanium implants depending on their insertion depth by histomorphometry. Material and methods: Four one-piece implants of identical geometry were inserted on each side of six mongrel dogs: (1) an uncoated zirconia implant, (2) a zirconia implant coated with a calcium-liberating titanium oxide coating, (3) a titanium implant and (4) an experimental implant made of a synthetic material (polyetheretherketone). In a split-mouth manner they were inserted in submerged and non-submerged gingival healing modes. After 4 months, dissected blocks were stained with toluidine blue in order to histologically asse…