Search results for " complement"
showing 10 items of 753 documents
Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments
2021
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production. Although the primary triggering factors of ITP remain unknown, a loss of immune tolerance—mostly represented by a regulatory T-cell defect—allows T follicular helper cells to stimulate autoreactive splenic B cells that differentiate into antiplatelet antibody-producing plasma cells. Glycoprotein IIb/IIIa is the main target of antiplatelet antibodies leading to platelet phagocytosis by splenic macrophages, through interactions with Fc gamma receptors (FcγRs) and complement receptors. This allows macrophages to activate autoreactive T cells …
Proton-irradiated breast cells: molecular points of view
2019
Abstract Breast cancer (BC) is the most common cancer in women, highly heterogeneous at both the clinical and molecular level. Radiation therapy (RT) represents an efficient modality to treat localized tumor in BC care, although the choice of a unique treatment plan for all BC patients, including RT, may not be the best option. Technological advances in RT are evolving with the use of charged particle beams (i.e. protons) which, due to a more localized delivery of the radiation dose, reduce the dose administered to the heart compared with conventional RT. However, few data regarding proton-induced molecular changes are currently available. The aim of this study was to investigate and descri…
ABO blood groups and Australia antigen
2008
The distribution of ABO blood in two groups of people with Australia antigen was studied (121 blood donors and 128 patients) and in 3,091 controls was investigated. There was a significant excess of A in comparison with o when the two groups were combined, and when the two groups were tested for (A + B): (AB +O) individually and together, both were found to be statistically significant. The results are discussed.
Strutture e trasformazioni condivise in matematica e musica: dalle categorie alla musicologia / Shared structures and transformations in mathematics …
2018
Le mutue influenze tra scienza e musica, iniziate con Pitagora, caratterizzano la ricerca musicale contemporanea, dalla teoria all'analisi della performance. La matematica può collegare campi diversi: in particolare, la teoria matematica delle categorie e, più in generale, il pensiero diagrammatico, costituiscono un potente strumento per analizzare i processi e le trasformazioni tra i processi. Una categoria è data da oggetti (punti) e trasformazioni tra di loro (frecce), che verificano la proprietà associativa e possiedono l’elemento neutro. Punti e frecce costituiscono diagrammi. Un'intera categoria può essere vista come un punto e le trasformazioni tra categorie possono essere rappresent…
Le domande computer-based dell'indagine OCSE-Pisa e le domande INVALSI: uno studio sperimentale sul confronto tra i due strumenti di somministrazione
2016
Le valutazioni standardizzate stanno orientandosi verso la somministrazione computer-based; in quest'ottica, la ricerca si è concentrata principalmente sull'analisi della comparabilità dei risultati e sullo studio delle eventuali differenze nelle performance degli allievi dovuti al passaggio ad un nuovo ambiente di somministrazione. Tale passaggio è tutt’altro che neutro. Questo articolo presenta la prima fase di una ricerca più ampia che si propone di indagare in maniera analitica le differenze di comportamento di studenti coinvolti nella risoluzione di test somministrati in ambiente cartaceo e computerizzato. L’obiettivo è definire e validare degli strumenti di analisi che permettano di e…
The second component of human complement: Detection of two hemolytic forms in plasma by pH Variation
1988
The second component of human complement (C2) in pseudoglobulin prepared from normal plasma eluted as a single peak at high conductivity (30 mS) and pH 4.5 from the cationic exchangers S-Sepharose or Mono S in the Fast Protein Liquid Chromatography (FPLC) System. The C2 was stable at pH 4.5 and 0 degrees C if enzyme inhibitors were used and the pH was raised to 6.0 after elution from the columns. After rechromatography on Mono S in the FPLC System at the median isoelectric point of 5.5 or pH 6.0, the C2 eluted as two distinct hemolytic forms: the first peaked at 16 mS, the second at 30 mS. The two forms of C2 did not correlate with the allotypic variant of C2 in individual, normal human pla…
Description of a Simple, Specific, and Sensitive Test for the Detection of Detergent-Solubilized C3b Receptor
1981
Abstract The C3b receptor was isolated from detergent-solubilized human erythrocyte membranes by a previously described technique (1). The receptor glycoprotein was shown to enhance EAC14oxy23b rosette formation with Raji lymphoblastoid cells. This provided a specific and sensitive test to detect the solubilized C3b receptor either in crude or highly purified form. The property of the C3b receptor tested by this assay appears to be analogous to properties of β1H.
Glutamine synthetase from roots of Brassica napus. Nucleotide sequence of a cytosolic isoform.
1994
The Anaphylatoxic Peptide C3a of Guinea Pig Complement
1978
Abstract Highly purified guinea pig C3a was obtained after specific cleavage of isolated C3 by the alternative pathway enzyme VF-B in a one step procedure. It turned out to be a low molecular weight peptide with basic character (M.W. 9500; isoelectric point above 9.4). C3a represents an antigenetic determinant of its own in the native C3 molecule, different from the B determinant. Guinea pig C3a is resistant to 100°C for 10 minutes. Its smooth muscle contracting activity can be destroyed by trypsin and carboxypeptidase B. These findings indicate that guinea pig C3a is quite similar to human C3a.
C1q
2000
Publisher Summary This chapter provides information to the physical properties, structure, and function of C1q protein. This protein is made up of three individual polypeptide chains, A, B and C, which are synthesized as pre-molecules with 22, 25, and 28 amino acid leader sequences, respectively. C1q has a characteristic appearance under the electron microscope, with six globular heads connected by six collagen-like stalks forming a central fibril stem. Glucosylgalactosyl disaccharide units are linked to certain hydroxylysine residues in the collagen regions of all three chains. C1q has a critical function in host defense and clearance of immune complexes. Antibody-independent activation of…