Search results for " complement"
showing 10 items of 753 documents
F-type lectin from the sea bass (Dicentrarchus labrax): purification, cDNA cloning, tissue expression and localization, and opsonic activity.
2009
Recently described biochemical and structural aspects of fucose-binding lectins from the European eel (Anguilla anguilla) and striped bass (Morone saxatilis) led to the identification of a novel lectin family ("F-type" lectins) characterized by a unique sequence motif and a characteristic structural fold. The F-type fold is shared not only with other members of this lectin family, but also with apparently unrelated proteins ranging from prokaryotes to vertebrates. Here we describe the purification, biochemical and molecular properties, and the opsonic activity of an F-type lectin (DlFBL) isolated from sea bass (Dicentrarchus labrax) serum. DlFBL exhibits two tandemly arranged carbohydrate-r…
Confrontare decimali e frazioni: analisi delle concezioni degli studenti a partire da una domanda INVALSI
2016
A partire da una domanda a risposta multipla tratta dai test standardizzati INVALSI per la quinta primaria, investighiamo la concezione di numero razionale sviluppata dagli studenti italiani. Lo scopo di questa ricerca è quello di individuare quali invarianti-operatori emergono dalle risposte degli studenti e quali di questi conducono più facilmente a conclusioni corrette o errate. Vengono anche osservati alcuni errori comuni nella conversione da frazione a decimale (e viceversa). Sono discusse alcune implicazioni per la pratica e la ricerca.
To B or Not to B: Comparative Genomics Suggests
2018
Insect lineages feeding on nutritionally restricted diets such as phloem sap, xylem sap, or blood, were able to diversify by acquiring bacterial species that complement lacking nutrients. These bacteria, considered obligate/primary endosymbionts, share a long evolutionary history with their hosts. In some cases, however, these endosymbionts are not able to fulfill all of their host's nutritional requirements, driving the acquisition of additional symbiotic species. Phloem-feeding members of the insect family Aleyrodidae (whiteflies) established an obligate relationship with Candidatus Portiera aleyrodidarum, which provides its hots with essential amino acids and carotenoids. In addition, ma…
Modified total variation regularization using fuzzy complement for image denoising
2015
In this paper, we propose a denoising algorithm based on the Total Variation (TV) model. Specifically, we associate to the regularization term of the Rodin-Osher-Fatimi (ROF) functional a small weight whenever denoising is performed in edge and texture regions, which means less regularization and more details preservation. On the other hand, a large weight is associated if the region being filtered is smooth which means noise will be well suppressed. The weight computation is inspired from the fuzzy edge complement. Experiments on well-known images and comparison with state of the art denoising algorithms demonstrate that the proposed method not only presents good denoising performance but …
Klein Concert: A Report from a Math-Musical Classroom Experience
2020
Can music help mathematical education? Can some shapes, that challenge visual imagination, be translated into music? I present a pedagogical application of my interdisciplinary research. This concerns a cycle of seminars about mathematics and music I gave in Italy at the Music Conservatory of Palermo and that, in a shortened version, I also gave at Ca’ Foscari University in Venice, at the Conservatory of Livorno, and in the UK, at the University of Greenwich. Seminars included a theoretical section and a workshop. Mathematical concepts helped students formalize their musical knowledge, and music provided an intuitive understanding of mathematical concepts, such as the dualism continuous/dis…
C1q–Ha matrix regulates the local synthesis of hyaluronan in malignant pleural mesothelioma by modulating has3 expression
2021
Increased hyaluronic acid (HA) production is often associated with cancer progression. In malignant pleural mesothelioma (MPM), HA is found at elevated levels in pleural effusions and sera of patients, and it has been widely debated whether MPM cells are able to produce HA by themselves or through the release of growth factors stimulating other cells. Another key component of the MPM microenvironment is C1q, which can act as a pro-tumorigenic factor favoring cell adhesion, migration and proliferation. The aim of the current study was to prove that MPM primary cells are able to synthesize HA and to inquire the stimulus given by C1q&ndash
Yoga en España. Proceso de regulación profesional
2015
New approaches to spirituality go hand in hand with emerging physical, psychological and spiritual movements that have had a clear impact on many areas, and in particular on health and well-being. It is increasingly common to find nurses teaching yoga or doctors prescribing mindfulness. Use of socalled Complementary and Alternative Medicine (CAM) is becoming mainstream. Health centres, medical practices and even schools are offering a growing number of alternative therapies, resulting in the need for effective legal regulation of these activities, both in terms of professional recognition and training. In Spain, recent legislation represents a significant breakthrough in the regulation of y…
Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth
2017
C1q is the first recognition subcomponent of the complement classical pathway, which acts towards the clearance of pathogens and apoptotic cells. C1q is also known to modulate a range of functions of immune and non-immune cells, including their involvement in placental development and sensorial synaptic pruning. We have recently shown that C1q can promote tumour by encouraging their adhesion, migration and proliferation in addition to angiogenesis and metastasis. In this study, we have examined the role of C1q in the microenvironment of malignant pleuric mesothelioma (MPM), a rare form of cancer commonly associated with exposure to asbestos. We found that C1q was highly expressed in all MPM…
Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications
2018
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriages. However, the exact mechanisms involved in the clinical manifestations of the syndrome are still a matter of investigation. In particular, while vascular thrombosis is apparently not associated with inflammation, the pathogenesis of miscarriages can be explained only in part by the aPL-mediated hypercoagulable state and additional non-thrombotic effects, including placental inflammation, have b…
Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent manner. Being a pattern recognition molecule of the innate immunity, C1q can recognize a number of self, non-self and altered-self ligands and bring about effector mechanisms designed to clear pathogens via opsonisation and inflammatory response. C1q is locally synthesized by macrophages and dendritic cells, and thus, can get involved in a range of biological processes, such as angiogenesis and tissue remodeling, immune modulation, and immu…