Search results for " determinism"
showing 10 items of 54 documents
Genome-wide association scan of attention deficit hyperactivity disorder
2008
Contains fulltext : 70191.pdf (Publisher’s version ) (Closed access) Results of behavioral genetic and molecular genetic studies have converged to suggest that genes substantially contribute to the development of attention deficit/hyperactivity disorder (ADHD), a common disorder with an onset in childhood. Yet, despite numerous linkage and candidate gene studies, strongly consistent and replicable association has eluded detection. To search for ADHD susceptibility genes, we genotyped approximately 600,000 SNPs in 958 ADHD affected family trios. After cleaning the data, we analyzed 438,784 SNPs in 2,803 individuals comprising 909 complete trios using ADHD diagnosis as phenotype. We present t…
The catechol o-methyltransferase (COMT) val158met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in fem…
2009
Wagner S, Baskaya O, Anicker NJ, Dahmen N, Lieb K, Tadic A. The catechol o‐methyltransferase (COMT) val158met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). Objective: We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMT Val158Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD). Method: One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss‐Durkee‐Hostility Inventory (BDHI). Result…
Beyond the Cultural Turn: A Critical Perspective on Culture-Discourse within Public Relations
2017
International audience; In 1992, Sriramesh and White (1992) pointed to the importance of culture for public relations. Two decades later, public relations scholars had answered their call in force (e.g., Bardhan & Weaver, 2011; Carayol & Frame, 2012; Edwards & Hodges, 2011; Sriramesh & Vercic, 2012). Sriramesh and other PR scholars have criticized much previous public relations research for its focus on the work of Hofstede and cultural characteristics that are apparently common across countries (Sriramesh, 2009), rather than approaches which present culture as a social phenomenon on the level of the social group (Frame, 2012), or as a communication resource or tool-kit (Swidler, 1986). Sri…
¿Es posible ser moralmente responsable? Notas para una nueva definición del concepto de sujeto
2006
The Strawson´s Basic Argument is the stronger against moral responsibility in Philosophy of action. One should be responsible of his identity to be moral responsible of his actions, but then nobody could be never responsible. In this article I criticize orthodox solutions to Strawson´s sceptical challenge and show how they share with the Argument the same theological notion of monadical agent. A new solution needs a new conception of agent..
Unambiguous recognizable two-dimensional languages
2006
We consider the family UREC of unambiguous recognizable two-dimensional languages. We prove that there are recognizable languages that are inherently ambiguous, that is UREC family is a proper subclass of REC family. The result is obtained by showing a necessary condition for unambiguous recognizable languages. Further UREC family coincides with the class of picture languages defined by unambiguous 2OTA and it strictly contains its deterministic counterpart. Some closure and non-closure properties of UREC are presented. Finally we show that it is undecidable whether a given tiling system is unambiguous.
Over the Cuckoo’s Nest : Towards a Nordic Model of the Responsible University?
2019
AbstractThis concluding chapter takes stock of the major elements, both empirical and conceptual, that underpin the case chapters presented in the book. The chapter is organised in three distinct sections. First, addressing a largely scientific audience, the chapter attempts to make conceptual sense of the findings from an organisational theory perspective. Second, it shifts focus to the wider community of practitioners (policy makers, advisers, university managers and administrators, etc.) by shedding light on the practical implications of the volume’s core findings for both policy and practice. Third, the chapter once again addresses an academic audience by sketching out the road ahead re…
Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families.
1999
Previously reported linkage of bipolar affective disorder to DNA markers on chromosome 18 was reexamined in a large sample of German bipolar families. Twenty-three short tandem repeat markers were investigated in 57 families containing 103 individuals with bipolar I disorder (BPI), 26 with bipolar II disorder (BPII), nine with schizoaffective disorder of the bipolar type (SA/BP), and 38 individuals with recurrent unipolar depression (UPR). Evidence for linkage was tested with parametric and non-parametric methods under two definitions of the affected phenotype. Analysis of all 57 families revealed no robust evidence for linkage. Following previous reports we performed separate analyses afte…
Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder
2008
Contains fulltext : 69243.pdf (Publisher’s version ) (Closed access) Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(S…
Sexual selection for genetic quality: disentangling the roles of male and female behaviour
2009
According to the good genes model of sexual selection, females choose males of good heritable genetic quality to obtain offspring with high fitness. However, better mating success of high-quality males can also be brought about by direct interference competition between males, or simply through elevated activity of high-quality males. We examined the roles of different processes leading to sexual selection for genetic quality in Drosophila montana. We manipulated genetic quality of male flies by inducing mutations with ionizing radiation. We then recorded the effects of inherited heterozygous mutations on several aspects of mating behaviour of males and females in two experiments. We found …
Genome search in celiac disease.
1998
SummaryCeliac disease (CD), a malabsorption disorder of the small intestine, results from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the entire genetic susceptibility. To determine the localization of other genetic risk factors, a systematic screening of the genome has been undertaken. The typing information of 281 markers on 110 affected sib pairs and their parents was used to test linkage. Systematic linkage analysis was first performed on 39 pairs in which both sibs had a symptomatic form of CD. Replication of the regions of interest was then carried out on 71 pairs in which one sib had a symptomatic form and the other a silent form of CD. …