Search results for " evaluation."

IS evolution benefit assessment: Challenges with economic investment criteria

2007

Maintenance and system evolution activities have a significant role in the information system (IS) life cycle. It has been estimated that approximately 80% of the total IT expenses are allocated for maintenance activities [20]. According to Lehman’s first law, maintenance is necessary, because software needs to be continuously improved or it will get out of date and cannot respond to the requirements of its environment [19]. Despite the importance of IS evolution investments, there is a gap between the IT related costs and company profitability [27]. Brynjolfssen [10] described this as a productivity paradox: information technology utilization has increased since the 70’s but simultaneously…

Análisis de las dinámicas de producción de conocimiento científico bajo el sistema de evaluación de la calidad de la Educación Superior y la Ciencia

2021

Tesis doctoral.-- Universidad de Valencia.

Evaluation des simulations spatiales

2006

The general topic is the evaluation of prospective scenarios for urban planning, especially for the management of urban built up areas. Several models of land-use and land-cover change (LUCC), based on different assumptions, allow producing realistic simulations of urban growth. Three ways can be distinguished for measuring the quality of modelings: 1. The choice of a model and its calibration; 2. The validation (showing if results are realistic); 3. The evaluation (showing if results respect defined planning goals). Measurement methods must be associated to these three steps.

Odor-induced change in saltiness: Enhancement of salt perception with salt-associated aroma

2007

Application of Imprinted Synthetic Polymers in Binding Assay Development

2000

The first part of the review describes a method for the synthesis of molecularly imprinted polymers for use in binding assays. The method considers the many factors involved that affect the recognition properties of the materials and describes an approach to screening and optimization of these factors. The second part describes the development of binding assays using such polymers. This includes the use of different labels, the effect of solvent and buffer, the scale of the assay (amount of solid polymer), and how these influence the quality of the assay in terms of sensitivity, selectivity, and speed of analysis.

Luminometric sub-nanoliter droplet-to-droplet array (LUMDA) and its application to drug screening by phase I metabolism enzymes.

2012

Here we show the fabrication of the Luminometric Sub-nanoliter Droplet-to-droplet Array (LUMDA chip) by inkjet printing. The chip is easy to be implemented and allows for a multiplexed multi-step biochemical assay in sub-nanoliter liquid spots. This concept is here applied to the integral membrane enzyme CYP3A4, i.e. the most relevant enzymatic target for phase I drug metabolism, and to some structurally-related inhibitors.

Determination of Plasma Lipid Hydroperoxides by an NADPH/NADP + Coupled Enzyme Reaction System. Evaluation of a Method

1998

Summary: Several techniques based on different principles have been proposed to measure lipid hydroperoxides. Enzymatic methods are sensitive and can be quite specific but they are subject to interference by inhibitors and not all are stoichiometric. The present work proposes some modifications of the Heath & Tappel (Anal Biochem 1976; 7:184—91) enzymatic method of determination of lipid hydroperoxides in order to standardize and automate it and to meet the analytical criteria required for a biological assay. The proposed new protocol and the automated assay give acceptable within-run and between-run precisions, with coefficients of variation of 3.34% and 5.80%, respectively, at the usual p…

Design, synthesis, biological evaluation and molecular modelling of substituted pyrrolo[2,1-a]isoquinolinone derivatives: discovery of potent inhibit…

2021

We report here the design, synthesis and biological evaluation of a new series of substituted pyrrolo[2,1-a]isoquinolin-3-one derivatives, some of which have strong inhibitory activity against both AChE and BChE enzymes. The design of these new inhibitors was carried out taking rivastigmine as the starting structure. Thus, on the basis of an exhausting molecular modeling study using combined techniques (docking, dynamic molecular simulations and QTAIM calculations), we obtained new ligands possessing stronger inhibitory effects than rivastigmine, the reference compound. QTAIM analysis gave us detailed information about the molecular interactions stabilizing the different ligand–enzyme compl…

Conducting sensory analysis tests among the elderly

2015

A cognitive/decision-making model of evaluation for ethical urban and building renewal

2009

Creativity is a strategic factor not only in the production sector, but also for planning, development and management of the city. The physical shape of the city is determined by the plan of buildings and settlements as a whole. Nevertheless, the functional and aesthetical criteria alone are inadequate, if you adopt the view of sustainability. In particular, from biological, ecological and economic points of view, the shape of the sustainable city is the result of a process of creative choice of traditional and innovative forms, materials and technologies that contribute to the quality of buildings and urban ambient. This principle applies a fortiori in cities interested by not-negligible p…