Search results for " evaluation."
showing 10 items of 1351 documents
Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence.
2007
The ubiquitin-proteasome pathway is the main proteolytic system present in the nucleus and cytoplasm of all eukaryotic cells. Apoptosis activation induced by ubiquitin-proteasome pathway inhibition makes the proteasome a new target of anticancer therapy. Bortezomib is the first proteasome inhibitor to be approved by the US FDA; in 2003 as a third line and in 2005 as a second line therapy for the treatment of multiple myeloma only. This review focuses on the use of bortezomib, not only in its therapeutic role but also, more specifically, in its biologic role and discusses the most recent applications of the drug in solid tumors, both at a preclinical and clinical level.
Cell Lines: A Tool for In Vitro Drug Metabolism Studies
2008
Primary cultured hepatocytes are a valuable in vitro model for drug metabolism studies. However, their widespread use is greatly hindered by the scarcity of suitable human liver samples. Moreover, the well-known in vitro phenotypic instability of hepatocytes, the irregular availability of fresh human liver for cell harvesting purposes, and the high batch-to-batch functional variability of hepatocyte preparations obtained from different human liver donors, seriously complicate their use in routine testing. To overcome these limitations, different cell line models have been proposed for drug metabolism screening. Human liver-derived cell lines would be ideal models for this purpose given thei…
Le varietà di grano duro per le semine 2021. Sicilia
2021
Anche nel 2020-21, pur nelle difficili circostanze determinate per il secondo anno consecutivo dalla pandemia da Covid-19, sono state condotte in Sicilia le prove della Rete nazionale di confronto varietale di frumento duro. I campi sperimentali sono stati allestiti in 5 ambienti siciliani. La sperimentazione ha riguardato 30 varieta’, di cui ben 9 al primo anno di valutazione. I risultati produttivi riscontrati nelle diverse localita’ appaiono molto differenti e fortemente influenzati dall’andamento meteorologico verificatosi nelle diverse zone dell’Isola. At 2020-21, despite the difficult circumstances determined for the second consecutive year by the Covid-19 pandemic, the tests of the n…
Le varietà di grano duro per le semine 2020: Sicilia
2020
Nonostante le difficoltà operative dovute alla pandemia da Covid-19, anche nel corso del 2019-20 sono state condotte in Sicilia le prove di confronto varietale di frumento duro, allestite in 5 località della Sicilia: Libertinia (Catania), Catania, S. Stefano Quisquina (Agrigento), Caltagirone (Catania) e Ciminna (Palermo). La sperimentazione ha riguardato 30 varietà, di cui 5 al primo anno di valutazione, 9 cultivar al secondo anno di prova e 16 genotipi testati da oltre due anni. La resa media dell’areale siciliano è stata pari a 6,11 t/ha e i risultati produttivi registrati nei diversi ambienti di prova appaiono sensibilmente influenzati dall’andamento termo-pluviometrico. Despite the dif…
Both Short- and Long-Acting D-1/D-2 Dopamine Agonists Induce Less Dyskinesia than l-DOPA in the MPTP-Lesioned Common Marmoset (Callithrix jacchus)
2002
Abstract The current concept of dyskinesia is that pulsatile stimulation of D-1 or D-2 receptors by l -DOPA or short-acting dopamine agonists is more likely to induce dyskinesia compared to long-acting drugs producing more continuous receptor stimulation. We now investigate the ability of two mixed D-1/D-2 agonists, namely pergolide (long-acting) and apomorphine (short-acting), to induce dyskinesia in drug-naive MPTP-lesioned primates, compared to l -DOPA. Adult common marmosets ( Callithrix jacchus ) were lesioned with MPTP (2 mg/kg/day sc for 5 days) and subsequently treated with equieffective antiparkinsonian doses of l -DOPA, apomorphine, or pergolide for 28 days. l -DOPA, apomorphine, …
Carga global, regional y nacional de neurológicas. Desórdenes, 1990-2016: un análisis sistemático para el Global Estudio de la carga de enfermedad 20…
2019
Publisher´s version (útgefin grein).
The 1-way on-line coupled model system MECO(n) – Part 4: Chemical evaluation (based on MESSy v2.52)
2016
Abstract. For the first time a simulation incorporating tropospheric and stratospheric chemistry using the newly developed MECO(n) model system is performed. MECO(n) is short for MESSyfied ECHAM and COSMO model nested n-times. It features an on-line coupling of the COSMO-CLM model, equipped with the Modular Earth Submodel System (MESSy) interface (called COSMO/MESSy), with the global atmospheric chemistry model ECHAM5/MESSy for Atmospheric Chemistry (EMAC). This on-line coupling allows a consistent model chain with respect to chemical and meteorological boundary conditions from the global scale down to the regional kilometre scale. A MECO(2) simulation incorporating one regional instance ov…
Applying a Mixed Method Design to Evaluate Training Seminars Within an Early Childhood Education Project
2008
Abstract The body of research relating to assessment in education suggests that professional developers and seminar administrators have generally paid little attention to evaluation procedures. Scholars have also been critical of evaluations which use a single data source and have favoured the use of a multiple method design to generate a complete picture of the effectiveness of procedures under evaluation. The purpose of the current study was to evaluate two training seminars using a mixed method design. The evaluation procedure was specifically designed to utilise triangulation of sources and to follow Killion's eight-step process. The seminars were part of the ‘Early Steps’ project, a Eu…
Evaluating the Regional Impact of a New Road on Tourism
2004
Ferri J. (2004) Evaluating the regional impact of a new road on tourism, Reg. Studies 38, 409–418. The aim of this work is to establish whether the opening of a motorway that extends along the east coast of Spain has significantly contributed to expanding hotel tourism in the Valencia region. Some of the most important tourist destinations in Spain, both domestic and international, are located in this region, such as Benidorm, Peniscola and Gandia. The A-7 motorway, also part of the E-15 road network, is not only a faster and safer means of road communication for tourists but also provides a new gate to Europe, connecting with other motorways. Using monthly data on nights spent in hotels by…
Agricultural landscapes and biodiversity conservation: a case study in Sicily (Italy)
2015
The diversity of life is made up not only of the diversity of plants and animal species, habitats and ecosystems, but also of the diversity of human cultures. These diversities interact with one another in complex ways and express the mutual adaptation between humans and the environment at local level. Sicilian traditional agro-ecosystems, due to the history of the territory and the resulting social and economic context, are configured in a heterogeneous mosaic rich in residual features of environmental value, which enhance the connectivity of the ecological network and support a high proportion of species that are rare or of conservation concern. As a case study we analyzed the characteris…