Search results for " growth"
showing 10 items of 4263 documents
Empirical links between natural mortality and recovery in marine fishes
2017
Probability of species recovery is thought to be correlated with specific aspects of organismal life history, such as age at maturity and longevity, and how these affect rates of natural mortality ( M ) and maximum per capita population growth ( r max ). Despite strong theoretical underpinnings, these correlates have been based on predicted rather than realized population trajectories following threat mitigation. Here, we examine the level of empirical support for postulated links between a suite of life-history traits (related to maturity, age, size and growth) and recovery in marine fishes. Following threat mitigation (medium time since cessation of overfishing = 20 years), 71% of 55 tem…
Life Skills e formazione iniziale dei docenti
2022
challenges of everyday life. Learning to live involves acquiring many skills, for which in some cases there is a natural predisposition, but which always require a "guided" exercise in real life contexts so that the person acquires the skills necessary to "live properly". The research was conducted with a group of 153 students from the Master of Science in Primary Education, who participated in a two-year training project during the academic years 2020-21 and 2021-22. This article describes whether and to what extent the students believe they have developed the four chosen life skills and which of the training methodologies adopted by the lecturers were most effective.
From arsenic to DDT: Pesticides, Fascism and the invisibility of toxic risks in the early years of Francoist Spain (1939-1953)
2021
This paper reviews the way in which Spanish agriculture climbed onto the pesticide treadmill. We claim that Fascist policies and expert advice assembled in the early 1940s accelerated the introduction of pesticides into Spanish agriculture and promoted the emergence of the Spanish pesticide industry in the times of autarky. Agricultural engineers were the key protagonists in this process, but other human and non-human actors also played a pivotal role: a new pest (the Colorado beetle), Francoist politicians, farmers, landowners and industry managers. Our focus is on the use of pesticides against the Colorado beetle (the main threat to the potato crop), and the transition from arsenical pest…
Evidence of autoinduction heterogeneity via expression of the agr system of listeria monocytogenes at the single-cell level
2011
ABSTRACT To investigate if the primary function of the Agr system of Listeria monocytogenes is to monitor cell density, we followed Agr expression in batch cultures, in which the autoinducer concentration was uniform, and in biofilms. Expression was heterogeneous, suggesting that the primary function of Agr is not to monitor population density.
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
Outlying location of logistics activities : the example of the Burgundy in France
2015
International audience; This paper contributes to the understanding of spatial location of logistics activities in an outlying region. A quantitative analysis in Burgundy (French region) underlines the important polarization of warehousing developed in a limited area during 1980–1990s intensified during 2000s. The companies that locate their warehouses in Burgundy have different strategies that could explain this outlying location. For example, the low cost of land, favorable terms of tax system and the presence of a labour pool with an important unemployed rate incentive could incentive some companies to locate their warehouses in an outlying region like the Burgundy.
Evaluation of the efficacy of a new insecticide paint against malaria vectors
2015
La malaria continúa siendo un problema de salud pública global. Se calcula que en el mundo hay 3.300 millones de personas en 97 países y territorios que corren el riesgo de padecer el paludismo, y que para 1.200 millones ese riesgo es elevado (WHO, 2014). El control de la malaria a gran escala está altamente basado en al control del vector, principalmente mediante el uso de mosquiteras tratadas con insecticidas de larga duración (LLINs), y en menor medida, el Rociamiento Residual Intradomiciliario. Todos los tratamientos recomendados de LLINs y la mayoría del Rociamiento Residual Intradomiciliario se basan en el uso de piretroides. La creciente resistencia de los vectores de malaria a los p…
The energy and identification continua of burnout and work engagement : Developmental profiles over eight years
2017
Abstract Understanding of the mutual developmental dynamics between burnout and work engagement is limited due to the lack of longitudinal studies with long follow-ups and multi-wave data. This study sought to identify subgroups of employees characterized by long-term exhaustion-vigor (energy continuum) and cynicism-dedication (identification continuum). A further important aim was to investigate differences between the identified subgroups in their experiences of progress in their personal work goals. Five-wave, eight-year follow-up data among Finnish white-collar professionals ( n = 168) were studied using Latent Profile Analysis (LPA). The analysis yielded three exhaustion-vigor subgrou…
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
2021
Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…