Search results for " interference"
showing 10 items of 340 documents
IP 3 signalling regulates exogenous RNA i in C aenorhabditis elegans
2015
RNA interference (RNAi) is a widespread and widely exploited phenomenon. Here, we show that changing inositol 1,4,5-trisphosphate (IP3) signalling alters RNAi sensitivity in Caenorhabditis elegans. Reducing IP3 signalling enhances sensitivity to RNAi in a broad range of genes and tissues. Conversely up-regulating IP3 signalling decreases sensitivity. Tissue-specific rescue experiments suggest IP3 functions in the intestine. We also exploit IP3 signalling mutants to further enhance the sensitivity of RNAi hypersensitive strains. These results demonstrate that conserved cell signalling pathways can modify RNAi responses, implying that RNAi responses may be influenced by an animal's physiology…
Potoczność naznaczona stylem nowych mediów. Interferencje międzystylowe w wypowiedziach pisemnych uczniów jako problem edukacyjny
2022
The article discusses the phenomenon of new media discourse permeating the language of written assignments produced in official school situations. The analysis of pupils’ essays concentrates on the colloquialisms transferred from social media discourse into the lexical layer of school writing. The author has assumed that the analysis will enable identifying educational barriers experienced by the new generation of pupils. The language of the texts under analysis combines the styles of written assignments, informal speech and of socialmedia discourse.
Vademecum lektora języka polskiego na Słowacji i w Czechach - pomoce dydaktyczne
2017
The purpose of this study is to describe the specificity of teaching Polish as a foreign language to Slovaks and Czechs (including the advantages and disadvantages resulting from language transfer), and to present the available teaching materials for Slovak and Czech students. The text includes an evaluation of the practical utility of different PFL textbooks designed for these groups and presents some suggestions for new teaching Solutions, such as the textbooks created at the Comenius University in Bratislava.
Politicisation of Travelling : Interrail and Freedom
2020
Travelling is today an important aspect of the European political agenda-setting of both individual actors and institutions. The paradigms of car and air travel are contested in terms of climate change; I continue the contestation from the perspective of political liberty. Three paradigms of personal travel – by car, by flight and by train – are confronted with two concepts of liberty: the freedom from interference versus the freedom from dependence. Three ideal types of travel – travelling to, travelling away and travelling around – are judged from the perspective of the two freedoms. Train travel by Interrail is a political innovation that links the freedom of movement to the freedom from…
A kétnyelvűség lenyomatai : Célnyelvi interferenciák Terézia Mora Das Ungeheuer című regényében és magyar fordításában
2018
The German writer Terézia Mora (1971) grew up with a double, Hungarian-German linguistic identity. She reflects on her own bilingualism in many ways, also on the micro level of the text. How can this linguistic duality be kept in the Hungarian translation? What translation strategies are to be applied in order to keep the intentional foreignness of the original in the Hungarian target text, if this foreignness is produced by using the very characteristics of the Hungarian language in the German original? This case study focuses on the reflection of bilingualism and the translation problems arising from reflection in literary texts by studying examples taken from the novel Das Ungeheuer by T…
All-Organic Waveguide Sensor for Volatile Solvent Sensing
2019
This work was supported by ERDF 1.1.1.1 Activity Project Nr. 1.1.1.1/16/A/046 “Application assessment of novel organic materials by prototyping of photonic devices”. We acknowledge Igors MIHAILOVS for valuable discussions.
La neologia en societat: verba sequuntur
2015
El punt de partida d’aquest article és de caràcter social: els neologismes apareixen per referir-se a les novetats del món i a altres necessitats expressives dels parlants. Atès que els parlants consideren seva la llengua i emeten judicis poc contrastats sobre les paraules noves, en aquest article es discuteixen alguns dels interrogants més habituals sobre aquest tema: què és un neologisme?, hi ha neologismes més neològics que d’altres?, per què apareixen neologismes?, són tots igualment necessaris?, com són els neologismes del català?, el català crea neologismes o només els copia d’altres llengües? La conclusió de l’article és que el català, com qualsevol altra llengua viva, té creativitat…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Solid phase extraction materials as a key for improving the accuracy of silver nanoparticle characterization with single-particle inductively coupled…
2022
The accurate characterization of silver nanoparticles (Ag NPs) in environmental samples is crucial for understanding the potential impact of these materials on the environment and human health. Single-particle inductively coupled plasma mass spectrometry (spICP-MS) is one of the few techniques available for quantifying NPs at environmentally relevant concentrations. However, the spICP-MS detection of Ag NPs can be interfered with coexisting dissolved analyte causing high background signals, which mask NP signals leading to a significant bias in NP characterization. In this paper, a simple sample pre-treatment procedure for efficient removal of dissolved silver in natural waters is proposed …
Diacylglycerol kinase α mediatses 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell …
2011
Increased levels of endogenous and/or exogenous estrogens are one of the well known risk factors of endometrial cancer. Diacylglycerol kinases (DGKs) are a family of enzymes which phosphorylate diacylglycerol (DAG) to produce phosphatidic acid (PA), thus turning off and on DAG-mediated and PA-mediated signaling pathways, respectively. DGK α activity is stimulated by growth factors and oncogenes and is required for chemotactic, proliferative, and angiogenic signaling in vitro. Herein, using either specific siRNAs or the pharmacological inhibitor R59949, we demonstrate that DGK α activity is required for 17-β-estradiol (E2)-induced proliferation, motility, and anchorage-independent growth of …