Search results for " lymphoma"

showing 10 items of 448 documents

Interobserver and intraobserver variability in the radiological assessment of sialolithiasis using cone beam computed tomography

2021

Background Data regarding the inter- and intraobserver variability in the radiological assessment of sialolithiasis using cone beam computed tomography are missing in the current literature. This study assessed the inter- and intraobserver variability in the radiological assessment of sialolithiasis using cone beam computed tomography (CBCT). Material and Methods In 107 patients, 130 salivary glands (65 parotid and 65 submandibular) with clinical signs of obstruction were assessed by four independent observers; 2 residents OMFS and 2 experienced OMFS. The observers analyzed the CBCT images and determined the absence or presence of one or more salivary stones in the affected gland. This proc…

Cone beam computed tomographycone-beam computed tomographyACCURACYSALIVARY STONESSalivary gland calculiSigns and symptomsnon-hodgkin lymphomahivSONOGRAPHYsurvivalstomatognathic systemMedicineHumansParotid GlandGeneral DentistryUNESCO:CIENCIAS MÉDICASOral Medicine and Pathologybusiness.industryResearchBackground dataSignificant differenceCone-beam computed tomographyCBCToral cancerSubmandibular glandobserver variationParotid glandmedicine.anatomical_structureObserver variationOtorhinolaryngologyRadiological weaponSurgeryprognosisbusinessNuclear medicineSIALENDOSCOPYKappa
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Interim 18f-PDGPET for Aggressive Non-Hodgking's Lymphoma: A Systematic Review and Meta-Analysis

2011

Abstract Abstract 5183 Background: The advantage of using interim 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) scan in the clinical work-up of patients with non-Hodgkin's lymphoma (NLH) is unclear. Data from meta-analyses are inconclusive, mainly because of the low number of patients evaluated and heterogeneity among studies. New clinical investigations, focused on this topic, have been recently published. We conducted an updated systematic review on the role of 18PDG-PET for the interim evaluation in patients with aggressive lymphomas. Materials and Methods: Medline, Embase, Scopus and Databases were searched for relevant studies through March 2011. We included studies t…

Contingency tablemedicine.medical_specialtybusiness.industryImmunologyMEDLINECell BiologyHematologymedicine.diseaseBiochemistryChemotherapy regimenTreatment failureLymphomaMeta-analysisInternal medicineInterimMedicineNuclear medicinebusinessDiffuse large B-cell lymphomaBlood
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A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk.

2011

Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many hematopoietic malignancies. The maintenance of regulated expression of these transporters is governed through the activation of intracellular "xenosensors" like the nuclear receptor 1I2/pregnane X receptor (NR1I2/PXR). SNPs in genes encoding these regulators have also been implicate…

Cytoplasmic And Nuclear ReceptorTechnologyCancer ResearchReceptors SteroidAbcg2Chronic lymphocytic leukemiaGeneBCL9Risk FactorsXenobioticATP Binding Cassette Transporter Subfamily G Member 2Poisonmultidrug resistance protein 2AlleleGeneticseducation.field_of_studyPregnane X receptorB-Cell Chronic Lymphocytic LeukemiabiologyMultidrug resistance-associated protein 2pregnane x receptorMultiple Drug ResistanceMultidrug Resistance-Associated Protein 2Neoplasm Proteinsmultidrug resistance 1Oncologybreast cancer resistance proteinMultidrug Resistance-Associated ProteinsCase-Control StudieBreast NeoplasmMultidrug Resistance-Associated ProteinsB-Cell LymphomaATP Binding Cassette Transporter Subfamily BATP-Binding Cassette TransporterMaintenancePopulationPopulationSingle-nucleotide polymorphismlymphomaPolymorphism Single NucleotideArticlemedicineHumansGenetic Predisposition to DiseaseATP Binding Cassette Transporter Subfamily B Member 1educationRegulator GeneHematologic NeoplasmProteinsmedicine.diseaseHaplotypeslymphoma; multidrug resistance 1; multidrug resistance protein 2; breast cancer resistance protein; pregnane x receptorSingle Nucleotide Polymorphismbiology.proteinNeoplasmATP-Binding Cassette Transporters
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Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression al…

2002

AbstractGenomic aberrations in a series of paired biopsy samples from patients who presented initially with follicle center lymphoma (FCL) and subsequently transformed to diffuse large B-cell lymphoma (DLBCL) were measured by array comparative genomic hybridization (CGH). The consequences of these aberrations on gene expression were determined by comparison with expression analysis on these specimens using cDNA microarrays. A heterogeneous pattern of acquired genomic abnormalities was observed upon transformation, some of which were recurrent in small subsets of patients. Some of the genomic aberration acquired upon transformation, such as gain/amplification of 1q21-q24, 2p16 (REL/BCL11A ge…

DNA ComplementaryImmunologyFollicular lymphomaLocus (genetics)BiologyAllelic ImbalanceBiochemistryGene duplicationmedicineChromosomes HumanHumansGeneLymphoma FollicularOligonucleotide Array Sequence AnalysisGeneticsChromosome AberrationsGene Expression ProfilingGene AmplificationCell BiologyHematologyDNA Neoplasmmedicine.diseaseBCL6Gene Expression Regulation NeoplasticCell Transformation NeoplasticDisease ProgressionLymphoma Large B-Cell DiffuseDNA microarrayChromosome DeletionDiffuse large B-cell lymphomaComparative genomic hybridizationBlood
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How I diagnose and treat splenic lymphomas.

2011

Abstract The incidental finding of an isolated splenomegaly during clinical assessment of patients evaluated for unrelated causes has become increasingly frequent because of the widespread use of imaging. Therefore, the challenging approach to the differential diagnosis of spleen disorders has emerged as a rather common issue of clinical practice. A true diagnostic dilemma hides in distinguishing pathologic conditions primarily involving the spleen from those in which splenomegaly presents as an epiphenomenon of hepatic or systemic diseases. Among the causes of isolated splenomegaly, lymphoid malignancies account for a relevant, yet probably underestimated, number of cases. Splenic lymphoma…

Diagnostic Imagingmedicine.medical_specialtyPathologyLymphomamedicine.medical_treatmentImmunologySplenectomySplenic lymphomaSpleen disorderSpleenEpiphenomenonBiochemistrytreatment.Splenic lymphomas; diagnosis; treatment.Bone MarrowInternal medicinemedicineHumansHematologybusiness.industrySplenic NeoplasmsCancerCell BiologyHematologymedicine.diseaseLymphomadiagnosimedicine.anatomical_structureSplenectomyDifferential diagnosisbusiness
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Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

2014

Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10 -20) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10 -11) near ETS1; 3q28 (rs6444305, p = 1.10 × 10 -10) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10 -10) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10 -8) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRß1 multiallelic amino acids at p…

EXPRESSIONFollicular lymphomaSingle-nucleotide polymorphismGenome-wide association studyHuman leukocyte antigenBiologyVARIANTSPolymorphism Single Nucleotidefollicular lymphomaHLA AntigensPolymorphism (computer science)ReportCLASS-IRESOURCEBiomarkers TumorGeneticsmedicineChromosomes HumanHumansTOOLGenetic Predisposition to DiseaseGenetics(clinical)PEPTIDEAlleleLymphoma FollicularAllelesGenetics (clinical)Genetic associationSNPSGeneticsRISKGenome-wide associationHaplotypemedicine.diseaseHLAHaplotypesCase-Control StudiesUNIVERSITYSETGenome-Wide Association Study
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Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified

2014

Peripheral T-cell lymphomas not otherwise specified (PTCLs/NOS) are rare and aggressive tumours whose molecular pathogenesis and diagnosis are still challenging. The microRNA (miRNA) profile of 23 PTCLs/NOS was generated and compared with that of normal T-lymphocytes (CD4+, CD8+, naive, activated). The differentially expressed miRNA signature was compared with the gene expression profile (GEP) of the same neoplasms. The obtained gene patterns were tested in an independent cohort of PTCLs/NOS. The miRNA profile of PTCLs/NOS then was compared with that of 10 angioimmunoblastic T-cell lymphomas (AITLs), 6 anaplastic large-cell lymphomas (ALCLs)/ALK+ and 6 ALCLs/ALK - . Differentially expressed…

Female; Gene Expression Profiling; Humans; Lymphoma T-Cell Peripheral; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; RNA Neoplasm; Gene Expression Regulation Neoplastic; Oncology; Hematology; Medicine (all)Malemedicine.medical_specialtyPathologyPeripheral T-cell lymphoma not otherwise specifiedBiologyhemic and lymphatic diseasesInternal medicinemicroRNAmedicineHumansRNA NeoplasmOligonucleotide Array Sequence AnalysisRegulation of gene expressionHematologymicroRNA; PTCLs/NOS; GEPOligonucleotide Array Sequence AnalysiGene Expression ProfilingMedicine (all)Not Otherwise SpecifiedLymphoma T-Cell PeripheralMicroRNAHematologymedicine.diseaseGEPLymphomaGene expression profilingGene Expression Regulation NeoplasticMicroRNAsOncologyPTCLs/NOSOriginal ArticleFemaleCD8Human
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Granulomatous mycosis fungoides, a rare subtype of cutaneous T-cell lymphoma

2015

Granulomatous mycosis fungoides (GMF) is an unusual histologic subtype of cutaneous T-cell lymphoma.1 The diagnosis of GMF is usually established after observation of a granulomatous inflammatory reaction associated with a malignant lymphoid infiltrate. Epidermotropism, a clue to diagnosis in classical mycosis fungoides (MF) may be absent in about 47% of cases of GMF.2 In some instances, the granulomatous component may be intense and obscures the lymphomatous component of the infiltrate.1 There are no distinctive clinical patterns associated with GMF.1, 3

GMF granulomatous mycosis fungoidesPathologymedicine.medical_specialtyMycosis fungoidesgranulomatous mycosis fungoidesbusiness.industryCutaneous T-cell lymphomaT-Cell Receptor Gamma GeneCase ReportDermatologyGranulomatous mycosis fungoidesmedicine.diseaseDermatologyINF-α interferon alfaGranulomatous dermatitisTCR T-cell receptormedicineT-cell receptor gamma geneMF mycosis fungoidesGranulomatous DermatitisbusinessJAAD Case Reports
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Anaplastic lymphoma kinase expression in neuroblastomas and its relationship with genetic, prognostic, and predictive factors

2011

Gene DosageReceptor Protein-Tyrosine KinasesProtein-Tyrosine KinasesBiologyPrognosisPathology and Forensic MedicineCohort StudiesSurvival RateNeuroblastomaExpression (architecture)Cancer researchHumansAnaplastic lymphoma kinaseAnaplastic Lymphoma KinaseChromosome DeletionIn Situ Hybridization FluorescenceNeoplasm StagingHuman Pathology
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Gene Expression Analysis Uncovers Similarity and Differences Among Burkitt Lymphoma Subtypes.

2011

Abstract Abstract 2494 Background. Burkitt lymphoma (BL) is currently listed in the WHO classification of lymphoid tumors as a single genetic and morphological entity with variation in clinical presentation. In particular, three clinical subsets of BL are recognized: endemic (eBL), sporadic (sBL) and immunodeficiency associated (ID-BL). Each affects different populations and can present with different features. So far, possible differences in their gene expression profiles (GEP) have not been investigated. In this study we aimed to 1) assess whether BL subtypes present with differences in their GEP; 2) investigate the relationship of the different BL subtypes with the non-neoplastic cellula…

Gene Expression Profiles; burkitt lymphomaGene expression analysieducationTransplantation HeterologousImmunologyMice NudeBiologyburkitt lymphomaBiochemistryBurkitt lymphoma.Micehemic and lymphatic diseasesCell Line TumormedicineAnimalsCluster AnalysisHumansRegulation of gene expressionGeneticsGene Expression ProfilesGENE EXPRESSION PROFILEMicroarray analysis techniquesGene Expression ProfilingGerminal centerCell BiologyHematologymedicine.diseaseMicroarray AnalysisPhenotypeLymphomaGene expression profilingTransplantationGene Expression Regulation NeoplasticPhenotypeBurkitt's lymphomaNeoplasm TransplantationGene expression analysis;Burkitt lymphoma.
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