Search results for " mac"
showing 10 items of 3066 documents
Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering (vol 5, pg 881, 2008)
2008
Influence of compliance for an elastokinematic model of a proposed rear suspension
2014
The research is carried out to improve passenger’s comfort to increase the vehicles stability in dynamic conditions. The literature available in the automotive engineering considers different topics for studying suspensions. An example represents mechanisms structure and analysis (synthesis, kinematics, and dynamics) under various operating conditions. These aspects have been approached before analytically, numerical. The current paper studies the influence of the lateral force on the contact patch of the wheel and the corresponding variations of vehicle stability parameters, such as camber angle and wheel rear track. The study is performed for a newer innovative rear suspensions mechanism …
Optimization of the characteristic angles of both front and rear McPherson suspensions on a circular track using multi-body numerical simulation
2009
The research reported in this paper aims to simulate the road-holding of a virtual vehicle using multi-body simulation to estimate both the contact forces between the tyre and ground and the roll motion when cornering. Furthermore, the effect of the characteristic angles on the variation in the forces of the tyre in contact with the ground is studied to determine optimal values for these angles. Emphasis is placed on an average-class vehicle, of which both the external dimensions and mass are chosen appropriately, with a McPherson suspension mounted on both the front and the rear. The characteristic values of the camber and toe-in angles, in both the front and the rear, are optimized for m…
Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages
2015
Glioblastoma cells produce and release high amounts of glutamate into the extracellular milieu and subsequently can trigger seizure in patients. Tumor-associated microglia/macrophages (TAMs), consisting of both parenchymal microglia and monocytes-derived macrophages (MDMs) recruited from the blood, are known to populate up to 1/3 of the glioblastoma tumor environment and exhibit an alternative, tumor-promoting and supporting phenotype. However, it is unknown how TAMs respond to the excess extracellular glutamate in the glioblastoma microenvironment. We investigated the expressions of genes related to glutamate transport and metabolism in human TAMs freshly isolated from glioblastoma resecti…
T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Mod…
2021
AbstractTumors undergo dynamic immunoediting as part of a process that balances immunologic sensing of emerging neoantigens and evasion from immune responses. Tumor-infiltrating lymphocytes (TIL) comprise heterogeneous subsets of peripheral T cells characterized by diverse functional differentiation states and dependence on T-cell receptor (TCR) specificity gained through recombination events during their development. We hypothesized that within the tumor microenvironment (TME), an antigenic milieu and immunologic interface, tumor-infiltrating peripheral T cells could reexpress key elements of the TCR recombination machinery, namely, Rag1 and Rag2 recombinases and Tdt polymerase, as a poten…
Tumor and its microenvironment: a synergistic interplay.
2013
The mutual and interdependent interaction between tumor and its microenvironment is a crucial topic in cancer research. Recently, it was reported that targeting stromal events could improve efficacies of current therapeutics and prevent metastatic spreading. Tumor microenvironment is a "complex network" of different cell types, soluble factors, signaling molecules and extracellular matrix components, which orchestrate the fate of tumor progression. As by definition, cancer stem cells (CSCs) are proposed to be the unique cell type able to maintain tumor mass and survive outside the primary tumor at metastatic sites. Being exposed to environmental stressors, including reactive oxygen species …
Possible involvement of the IL4 gene in Waldenström's macroglobulinemia
1994
Abstract We report the results of a molecular investigation of 11 patients affected by Waldenstrom's macroglobulinemia, a rare B-cell malignancy characterized by an excessive proliferation of immunoglobulin(Ig)M-secreting plasmacytoid cells. In particular, we studied the interleukin-4 (IL4) gene, which codes for a B-specific growth factor capable of stimulating the proliferation and differentiation of secreting plasma cells. By Southern hybridization, in three patients we found the presence of additional bands in comparison with the expected pattern; moreover, these bands showed a different degree of intensity.
Functional and Therapeutic Significance of Tumor-Associated Macrophages in Colorectal Cancer
2022
The role of the tumor microenvironment (TME) in the progression of colorectal cancer (CRC) and its acquisition of resistance to treatment become the research hotspots. As an important component of TME, the tumor-associated macrophages (TAMs) regulate multiple critical oncogenic processes, namely, occurrence, proliferation, metastasis, and drug resistance in CRC. In this review, we have discussed the functional and therapeutic significance of TAMs in CRC. M1 macrophages act as the tumor suppressor while M2 macrophages promote CRC. The polarization of TAMs is mainly regulated by the pathways such as NFKB1 pathways, STAT3 pathways, WNT5A pathways, and PI3K pathways in CRC. Furthermore, the M2 …
New insight into the genetics of age-related macular degeneration in connection with lipid metabolism
2010
Evaluation of: Zerbib J, Seddon JM, Richard F et al. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS ONE 4(10), e7341 (2009).Age-related macular degeneration (AMD) is the leading cause of visual loss in elderly populations of Western countries. According to demographic forecasts, and owing to the improvement in life expectancy, the number of people suffering from this pathology is expected to dramatically increase in the near future, thereby becoming a significant socioeconomic burden. There has been great progress in defining risk factors for AMD over the last few decades. Beyond advanced age, environmental and genetic factors ha…
The organismic and the continuous approaches applied to phytosociological relationships in a lowland neotropical forest, Venezuela
2011
Abstract The Organismic and the Continuous theories are traditionally considered as antagonist in ecology studies. In this research, we make the floristic characterization of different forest communities and establish the corresponding classification, taking into account the approaches derived from the theories aforementioned. We used 1 ha plots to evaluate individuals bigger than 10 cm dbh (diameter at breast height). In each one of that plots, four sub-plots of 100 m2 were measured, to study all the spermatophyta in the understory. The data obtained were considered in an Enlarged Importance Index (EII), for each species in each plot. Then, the phytosociological relationships were establis…