Search results for " memory"

Aminobisphosphonate-activated γδ T cells in immunotherapy of cancer: doubts no more

2008

BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill most tumour cells because of recognition by T cell receptor and natural killer receptors. OBJECTIVE: We discuss the possibility that the intentional activation of gammadelta T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in cancer patients. METHODS: The antitumoral effects of gammadelta T cells both in vitro and in vivo have been demonstrated suggesting a new therapeutic approach for translation into the clinical setting. RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent a particularly interesting target for immunotherapeutic …

Selective erasure of a fear memory

2009

International audience; Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased cyclic adenosine monophosphate response element-binding protein (CREB) are preferentially activated by fear memory expression, which suggests that they are selectively recruited into the memory trace. We used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning b…

Dissociation between priming and recognition in the expression of sequential knowledge

2002

Exposure to a repeating sequence of target stimuli in a speeded localization task can support both priming of sequence-consistent responses and recognition of sequence components. Here, a task is introduced in which measures of priming and recognition are obtained concurrently, and it is demonstrated that priming of sequence-consistent responses occurs even when test stimuli are not recognized. The results show that sequence knowledge can be expressed in the absence of conscious recognition. However, we also show that this result is consistent with a simple model in which priming and recognition depend on exactly the same underlying memory strength variable.

[IC‐P‐152]: ASSOCIATION OF CORTICAL AMYLOID LOAD WITH RESTING‐STATE EEG FUNCTIONAL CONNECTIVITY IN SUBJECTIVE MEMORY COMPLAINERS FROM THE INSIGHT‐PRE…

2017

Transcranial direct current stimulation over the right DLPFC selectively modulates subprocesses in working memory

2018

Background Working memory, as a complex system, consists of two independent components: manipulation and maintenance process, which are defined as executive control and storage process. Previous studies mainly focused on the overall effect of transcranial direct current stimulation (tDCS) on working memory. However, little has been known about the segregative effects of tDCS on the sub-processes within working memory. Method Transcranial direct current stimulation, as one of the non-invasive brain stimulation techniques, is being widely used to modulate the cortical activation of local brain areas. This study modified a spatial n-back experiment with anodal and cathodal tDCS exertion on th…

Amnesia and the hippocampus

2006

PURPOSE OF REVIEW: Long-term memory impairments have great medical significance and a considerable health and economic burden. Understanding their cognitive and neuroanatomical underpinnings is of crucial importance. Severe amnesia is usually observed following bilateral hippocampal pathology. This review addresses the precise role of the hippocampus and related medial temporal lobe structures in amnesia. RECENT FINDINGS: Disagreements exist over whether, following selective hippocampal damage: retrograde amnesia for episodic memories is temporally limited or extensive and ungraded; anterograde amnesia involves both recollective and familiarity processes. It is accepted that material specif…

Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes

2005

Selective depletion of alloreactive T cells from stem-cell allografts should abrogate graft-versus-host disease while preserving beneficial T cell specificities to facilitate engraftment and immune reconstitution. We therefore explored a refined immunomagnetic separation strategy to effectively deplete alloreactive donor lymphocytes expressing the activation antigen CD69 upon stimulation, and examined the retainment of antiviral, antileukemic, and immunoregulatory T cells. In addition to the CD69high T cell fraction, our studies retrieved two T cell subsets based on residual CD69 expression. Whereas, truly CD69(neg) cells were devoid of detectable alloresponses to original stimulators, CD69…

"L'albero Falcone" e i suoi epigoni. La propagazione vegetale della memoria antimafia

2021

Le stragi di Capaci e via D’Amelio segnano un punto di svolta nel linguaggio con cui i movimenti antimafia costruiscono la memoria pubblica della violenza mafiosa. Uno dei tratti salienti di questa svolta è la proliferazione di luoghi di memoria che ruotano intorno a figure arboree. Il capostipite di questa genealogia è l’albero Falcone, noto come punto di raccolta per le manifestazioni del 23 maggio, la giornata della legalità. Nel corso degli anni ’90, il modello memoriale costruito intorno all’albero si sviluppa e si diffonde, mentre sono sempre già frequenti le piantumazioni di alberi in memoria delle vittime della mafia. L’articolo cerca di esplicitare le forme semiotiche soggiacenti a…

Tradizione socialista e martirologio antimafia. La memoria di Lorenzo Panepinto e Bernardino Verro

2023

Socialist victims of the Mafia, Bernardino Verro and Lorenzo Panepinto were killed in the 1910s (1911 and 1915). For a long time, they were commemorated by the Socialist Party, which celebrated them as victims of the class struggle. However, as Marxist identities weakened in the 20th century, their memory was increasingly discussed as part of a debate on mafia victims. The essay aims to study this shift.

Kādreizējo fabrikas strādnieku sociālekonomisko pārmaiņu pieredzes postsociālisma Lietuvā

2017

Šī maģistra darba mērķis ir sniegt vēsturiski situētu etnogrāfisku ieskatu, kas apraksta un kontekstualizē bijušo rūpnīcu strādnieku ikdienas dzīves postsociālistiskā Lietuvā. Šis pētījums seko personīgiem naratīviem par darbu kā pieredzēm socialistiskā pārvaldes sistēmā. Tas skaidro kā šīs pieredzes tiek atsauktas atmiņā un iekļautas tagadnes naratīvos. Šis etnogrāfiskais pētījums balstās vairākās datu ieguves metodēs, tai skaitā, arhīva materiālu analīzē, daļēji strukturētās intervijās, novērojumos, kā arī vizuālās antropoloģijas metodēs. Šis pētījums ir ievietojams plašākā postsociālisma antropoloģijas debatē. Tas parāda, kā kolektīvās atmiņas un kolektīvās aizmiršanas koncepti, kā arī n…