Search results for " mito."
showing 10 items of 892 documents
Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity.
2009
Strong evidence indicates that oxidative stress may be causally involved in the pathogenesis of Parkinson's disease. We have employed human dopaminergic neuroblastoma cells and rat primary mesencephalic neurons to assess the protective potential of three novel bisarylimine antioxidants on dopaminergic cell death induced by complex I inhibition or glutathione depletion. We have found that exceptionally low concentrations (EC(50) values approximately 20 nM) of these compounds (iminostilbene, phenothiazine, and phenoxazine) exhibited strong protective effects against the toxicities of MPP(+), rotenone, and l-buthionine sulfoximine. Investigating intracellular glutathione levels, it was found t…
Le forme del tempo. Miti, fiabe, immagini di Italo Calvino
2004
Monografia su Italo Calvino attaverso una disamina antropologica della sua intera produzione, con particolare attenzione alla presenza del mito, della fiaba e ai problemi della visione.
To the research of treatments for the typical calcific disease of old aortic valve in the omics era: Is the miR-195 a therapeutic signature via targe…
2020
Calcific aortic valve disease (CAVD) is the most frequent form of val-vular pathology [1,2], with high percentages of mortality and morbidityin Western populations, so much to be a very public health problem [2].Diverse millions of subjects are affected by CAVD and the major numberare old individuals (65- older), even if some have a younger age and aregenerally affected by congenital bicuspid aortic valve (BAV) disease[2,3]. CAVD in BAV individuals arises decades earlier respect to subjectswith the physiological tricuspid aortic valve [3]. Furthermore, it can leadto death if untreated with surgical aortic valve replacement or trans-catheter aortic valve implantation, its unique treatments […
DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).
2009
Abstract The impact of DNA damage-induced replication blockage for early activation of stress kinases [stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK)] is largely unknown. Here, we show that induction of dual phosphorylation of SAPK/JNK by the DNA polymerase inhibitor aphidicolin was not ameliorated by additional exposure to ultraviolet (UV) light, indicating that overlapping mechanisms participate in signaling to SAPK/JNK triggered by both agents. UV-induced DNA replication blockage, cyclobutane pyrimidine dimer formation and DNA strand break induction coincided with SAPK/JNK phosphorylation at early (≤ 30 min) but not late (≥ 2 h) time points after exposure. Genotoxin…
Neuronal cell cycle: the neuron itself and its circumstances.
2015
Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined developmental program that induces DNA replication in specific populations of neurons, which remain in a tetraploid state for the rest of their adult life. Similarly, de novo neuronal tetraploidization has also been described in the adult brain as an early hallmark of neurodegeneration. The aim of this review is to integrate these recent developments in the context of cell cycle regulation and apoptotic cell death in neurons. We conclude that a variety of mechanisms exists in neuronal cells for G1/S and G2/M check…
Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells.
2011
SUMMARYAlthough many cancer cells are primed for apoptosis, they usually develop resistance to cell death at multiple levels. Permeabilization of the outer mitochondrial membrane, which is mediated by proapoptotic Bcl-2 family members like Bax, is considered as a point-of-no-return for initiating apoptotic cell death. This crucial role has placed Bcl-2 family proteins as recurrent targets for anticancer drug development. Here, we propose and demonstrate a new concept based on using minimal active version of Bax to induce cell death independently of endogenous Bcl-2 proteins. We show that membrane-active segments of Bax can directly induce the release of mitochondria-residing apoptogenic fac…
Beyond the myth: A social interpretation about the mosaic of the Twelve Labours of Hercules (Liria, Valencia)
2018
On the occasion of the centenary of the mosaic’s discovery of the Twelve Labours of Hercules in Liria (Valencia), this article aims to approach to some aspects overlooked in previous works. Within the study of Roman domestic spaces, the room’s decoration is an essential factor in order to understand its function. Over the years, several studies have focused their efforts on a descriptive analysis of the mosaic, mentioning only the social interpretation, whereas the current trends try to analyze other aspects such as the study of elites and their symbolism. For this reason, our goal in this article is to analyze the social aspect of this pavement, which particular choice of the central motif…
Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial B…
2014
International audience; The objective of this study was to evaluate the biological activities of the major phytosterols present in argan oil (AO) and in cactus seed oil (CSO) in BV2 microglial cells. Accordingly, we first determined the sterol composition of AO and CSO, showing the presence of Schottenol and Spinasterol as major sterols in AO. While in CSO, in addition to these two sterols, we found mainly another sterol, the Sitosterol. The chemical synthesis of Schottenol and Spinasterol was performed. Our results showed that these two phytosterols, as well as sterol extracts from AO or CSO, are not toxic to microglial BV2 cells. However, treatments by these phytosterols impact the mitoch…
Arquitectura modernista valenciana: el Círculo Frutero Burrianense
2011
El artículo analiza los aspectos históricos, económicos y artísticos del Círculo Frutero Burrianense, un edificio construido en la ciudad de Burriana (Castellón) en 1916 para servir de apoyo a la explotación y comercialización de cítricos. El estudio profundiza en la autoría; su relación con la vertiente más racionalista de la Arquitectura Modernista, emparentada con la Secesión Vienesa; y se hace un comentario de los elementos constitutivos del interior y del exterior, junto al desciframiento iconográfico de los temas que figuran en la fachada. Se ha hecho un esfuerzo especial por sacar a la luz toda la documentación conservada sobre el inmueble. (A)
Del héroe épico al héroe trágico: la progresión de los planteamientos éticos en la Ilíada
2019
Na Ilíada, em alguns dos seus heróis mais relevantes, podemos ver a transição de uma cultura em que o ser humano é um objeto nas mãos dos deuses ou do destino para uma posição em que o ser humano assume a responsabilidade no contexto de uma interação entre o plano humano e o plano divino, posição em que atuaram, nos seus respetivos pressupostos dramáticos, os heróis de Ésquilo e também os de Sófocles e os de Eurípides.