Search results for " modifica"
showing 10 items of 817 documents
"Table 5" of "Measurement of prompt photon production in $\sqrt{s_\mathrm{NN}} = 8.16$ TeV $p$+Pb collisions with ATLAS"
2019
The nuclear modification factor R_pPb for prompt, isolated photons with rapidity in (−1.84,0.91).
"Table 6" of "Measurement of prompt photon production in $\sqrt{s_\mathrm{NN}} = 8.16$ TeV $p$+Pb collisions with ATLAS"
2019
The nuclear modification factor R_pPb for prompt, isolated photons with rapidity in (−2.83,−2.02).
Palladium-catalyzed dehydrogenative β'-functionalization of β-keto esters with indoles at room temperature.
2012
The dehydrogenative β′-functionalization of α-substituted β-keto esters with indoles proceeds with high regioselectivities (C3-selective for the indole partner and β′-selective for the β-keto ester) and good yields under mild palladium catalysis at room temperature with a variety of oxidants. Two possible mechanisms involving either late or early involvement of indole are presented.
Palladium-catalyzed domino C-H/N-H functionalization: an efficient approach to nitrogen-bridged heteroacenes.
2015
Palladium-catalyzed domino C-H/N-H functionalization for the synthesis of novel nitrogen-bridged thienoacenes and 10H-benzo[4,5]thieno[3,2-b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial C-H functionalization of the benzo[b]thiophene moiety, followed by Buchwald-Hartwig coupling. This transformation is also useful for the synthesis of highly π-extended compounds.
ChemInform Abstract: Palladium-Catalyzed Dehydrogenative β′-Functionalization of β-Keto Esters with Indoles at Room Temperature.
2012
The dehydrogenative β′-functionalization of α-substituted β-keto esters with indoles proceeds with high regioselectivities (C3-selective for the indole partner and β′-selective for the β-keto ester) and good yields under mild palladium catalysis at room temperature with a variety of oxidants. Two possible mechanisms involving either late or early involvement of indole are presented.
ChemInform Abstract: Palladium-Catalyzed Domino C-H/N-H Functionalization: An Efficient Approach to Nitrogen-Bridged Heteroacenes.
2015
Palladium-catalyzed domino CH/NH functionalization for the synthesis of novel nitrogen-bridged thienoacenes and 10H-benzo[4,5]thieno[3,2-b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial CH functionalization of the benzo[b]thiophene moiety, followed by Buchwald–Hartwig coupling. This transformation is also useful for the synthesis of highly π-extended compounds.
Synthesis and in Vitro Evaluation of Biotinylated RG108: A High Affinity Compound for Studying Binding Interactions with Human DNA Methyltransferases
2006
Small-molecule inhibitors of DNA methyltransferases such as RG108 represent promising candidates for cancer drug development. We report the synthesis and in vitro analysis of a biotinylated RG108 conjugate, 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(5-[3-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)pentanoylamino]propoxy]-1H-indol-3-yl)propionic acid (bio-RG108), for the evaluation of interactions with DNA methyltransferase enzymes. The structural design of the chemically modified inhibitor was aided by molecular modeling, which suggested the possibility for extensive chemical modifications at the 5-position of the tryptophan moiety in RG108. The inhibitory activity of the corresponding d…
Progettazione per la realizzazione della Ricostruzione Corpo Centrale Ex Biblioteca della Stazione Zoologica Anton Dohrn
2017
Il recupero architettonico e funzionale della ex Biblioteca della Stazione Zoologica di Napoli ha un significato che va evidentemente oltre le ridotte dimensioni del suo ingombro e del suo volume. L’intervento cerca di interpretare il piccolo elemento - limitato dai 2 edifici storici adiacenti - come tassello di un processo rigenerativo completo, a livello di uso come di immagine complessiva, in un’area urbana tanto significativa quanto delicata. La volontà del progetto di concorso può essere descritta e comunicata attraverso una serie di parole chiave: RISEMANTIZZAZIONE Da un punto di vista della facciata e dell’immagine complessiva dell’edificio, la sostituzione della superficie collocata…