Search results for " modifica"
showing 10 items of 817 documents
LA PRATICA DEL RIUSO COME STRUMENTO DEL PROGETTO DI ARCHITETTURA
2018
La città contemporanea è una realtà eterogenea creata da un insieme di diversi e discontinui ambienti in cui il tempo e l'azione umana sono resi espliciti. Poiché gli ambienti sono configurati come vuoti urbani, spazi interstiziali situati in vari modi all'interno di città costituite da centri storici, aree industriali dismesse, complessi residenziali suburbani, a cui si aggiungono i numerosi edifici e spazi abbandonati. La presenza di un numero considerevole di edifici in disuso in città pone alcune domande che sono difficili da dare risposte univoche, vale a dire: la qualità di questi edifici abbandonati, il loro significato e le ragioni per cui dovrebbero essere mantenuti. Intervieni qui…
Poly(sarcosine) surface modification imparts stealth-like properties to liposomes
2019
Circulation lifetime is a crucial parameter for a successful therapy with nanoparticles. Reduction and alteration of opsonization profiles by surface modification of nanoparticles is the main strategy to achieve this objective. In clinical settings, PEGylation is the most relevant strategy to enhance blood circulation, yet it has drawbacks, including hypersensitivity reactions in some patients treated with PEGylated nanoparticles, which fuel the search for alternative strategies. In this work, lipopolysarcosine derivatives (BA-pSar, bisalkyl polysarcosine) with precise chain lengths and low polydispersity indices are synthesized, characterized, and incorporated into the bilayer of preformed…
Covalent RGD modification of the inner pore surface of polycaprolactone scaffolds
2011
Scaffold production for tissue engineering was demonstrated by means of a hot compression molding technique and subsequent particulate leaching. The utilization of spherical salt particles as the pore-forming agent ensured complete interconnectivity of the porous structure. This method obviated the use of potentially toxic organic solvents. To overcome the inherent non-cell-adhesive properties of the hydrophobic polymer polycaprolactone (PCL) surface activation with a diamine was performed, followed by the covalent immobilization of the adhesion-promoting RGD-peptide. The wet-chemical approach was performed to guarantee modification throughout the entire scaffold structure. The treatment wa…
(-)-Isosteviol as a Versatile Ex-Chiral-Pool Building Block for Organic Chemistry
2013
(–)-Isosteviol is readily available in large quantities by the acidic treatment of a common alternative sweetener. The two functional groups of (–)-isosteviol are presented on the same side of the ent-beyerane scaffold with a mutual C–C distance of about 7 A. Their unique concave arrangement experiences a strong asymmetric environment due to an adjacent methyl group. Consequently, this building block has found several applications in supramolecular chemistry and organocatalysis. These areas and the chemical modification of this scaffold as well as its biological activity are surveyed.
Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification
2014
Ribosome heterogeneity is of increasing biological significance and several examples have been described for multicellular and single cells organisms. In here we show for the first time a variation in ribose methylation within the 18S rRNA of Saccharomyces cerevisiae. Using RNA-cleaving DNAzymes, we could specifically demonstrate that a significant amount of S. cerevisiae ribosomes are not methylated at 2'-O-ribose of A100 residue in the 18S rRNA. Furthermore, using LC-UV-MS/MS of a respective 18S rRNA fragment, we could not only corroborate the partial methylation at A100, but could also quantify the methylated versus non-methylated A100 residue. Here, we exhibit that only 68% of A100 in t…
A survey on tubulin and arginine methyltransferase families sheds light on p. lividus embryo as model system for antiproliferative drug development
2019
Tubulins and microtubules (MTs) represent targets for taxane-based chemotherapy. To date, several lines of evidence suggest that effectiveness of compounds binding tubulin often relies on different post-translational modifications on tubulins. Among them, methylation was recently associated to drug resistance mechanisms impairing taxanes binding. The sea urchin is recognized as a research model in several fields including fertilization, embryo development and toxicology. To date, some &alpha
Tuning the surface of nanoparticles: Impact of poly(2-ethyl-2-oxazoline) on protein adsorption in serum and cellular uptake
2016
Item does not contain fulltext Due to the adsorption of biomolecules, the control of the biodistribution of nanoparticles is still one of the major challenges of nanomedicine. Poly(2-ethyl-2-oxazoline) (PEtOx) for surface modification of nanoparticles is applied and both protein adsorption and cellular uptake of PEtOxylated nanoparticles versus nanoparticles coated with poly(ethylene glycol) (PEG) and non-coated positively and negatively charged nanoparticles are compared. Therefore, fluorescent poly(organosiloxane) nanoparticles of 15 nm radius are synthesized, which are used as a scaffold for surface modification in a grafting onto approach. With multi-angle dynamic light scattering, asym…
Effetti della tecnologia Modified Atmosphere Packaging a base di argon sulla qualità degli arilli di melograno (Punica granatum L. cv. Wonderful)
2021
La coltivazione del melograno è aumentata globalmente nell’ultimo decennio grazie ai rinomati benefici del frutto per la salute. Il consumo del melograno come frutto fresco, però, incontra delle resistenze da parte dei consumatori a causa della scomodità di estrazione degli arilli dal frutto e della presenza di metaboliti fenolici che possono macchiare le mani. Oggi si sta diffondendo sempre più il consumo di arilli pronti al consumo, pratici e veloci in confezionamento protettivo per cui occorre mantenere inalterate le caratteristiche qualitative del frutto fresco. Il confezionamento in atmosfera modificata (MAP) è stato utilizzato negli ultimi anni per mantenere la qualità della frutta di…
Effetto di diversi trattamenti Modified Atmosphere Packaging (MAP) sulla qualità di frutti di gelso (Morus alba L. cv Kokuso 21)
2021
Il consumo italiano di piccoli frutti ha visto un notevole incremento nell’ultima decade grazie alla maggior attenzione rivolta dal consumatore al valore nutrizionale della frutta fresca. Il gelso è un frutto climaterico, caratterizzato da un elevato contenuto in carotene, vitamine B1, B2 e C, glucosio, saccarosio, acido tartarico e succinico, fenoli totali e antociani. Grazie al suo particolare valore nutraceutico il gelso è considerato oltre che un alimento funzionale anche un prodotto di alta gamma. Tuttavia, la commercializzazione di questo tipo di frutto è ancora in certa misura ostacolata dalla loro spiccata deperibilità ed è pertanto necessario sviluppare metodi in grado di estendern…
La confezione in atmosfera controllata migliora la qualità post-raccolta del lici
2018
La coltivazione del frutto in Sicilia è una realtà in espansione e su cui in futuro puntare. Necessario affinare le tecniche di conservazione per allungare la shelf-life dei frutti di lici