Search results for " multiple"
showing 10 items of 903 documents
Reducing the peak and average power for OFDM systems using QAM by constellation shaping
2009
In this paper, we present a shell mapping scheme to reduce the peak and average power of orthogonal frequency division multiplexing (OFDM) signals using quadrature amplitude modulation (QAM) by constellation shaping. Our approach can be considered as an extension of the shell mapping technique introduced originally in the V.34 recommendation of ITU-T. The shell mapping method uses multiple cost functions, each having the OFDM block length N as a parameter. The cost functions are presented in closed form for any N. The main advantage of the proposed scheme is that the peak and average power can be reduced without sacrificing the data rate, and no side information is needed at the receive sid…
TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)
2015
Joubert syndrome (JBTS) is a severe recessive neurodevelopmental ciliopathy which can affect several organ systems. Mutations in known JBTS genes account for approximately half of the cases. By homozygosity mapping and whole-exome sequencing, we identified a novel locus, JBTS23, with a homozygous splice site mutation in KIAA0586 (alias TALPID3), a known lethal ciliopathy locus in model organisms. Truncating KIAA0586 mutations were identified in two additional patients with JBTS. One mutation, c.428delG (p.Arg143Lysfs*4), is unexpectedly common in the general population and may be a major contributor to JBTS. We demonstrate KIAA0586 protein localization at the basal body in human and mouse p…
Potential Biomarkers Associated with Multiple Sclerosis Pathology
2021
Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS) that involves an intricate and aberrant interaction of immune cells leading to inflammation, demyelination, and neurodegeneration. Due to the heterogeneity of clinical subtypes, their diagnosis becomes challenging and the best treatment cannot be easily provided to patients. Biomarkers have been used to simplify the diagnosis and prognosis of MS, as well as to evaluate the results of clinical treatments. In recent years, research on biomarkers has advanced rapidly due to their ability to be easily and promptly measured, their specificity, and their reproducibility. Biomarkers are classified into several categor…
The Polarised Valence Quark Distribution from semi-inclusive DIS
2007
The semi-inclusive difference asymmetry A^{h^{+}-h^{-}} for hadrons of opposite charge has been measured by the COMPASS experiment at CERN. The data were collected in the years 2002-2004 using a 160 GeV polarised muon beam scattered off a large polarised ^6LiD target and cover the range 0.006 < x < 0.7 and 1 < Q^2 < 100 (GeV/c)^2. In leading order QCD (LO) the asymmetry A_d^{h^{+}-h^{-}} measures the valence quark polarisation and provides an evaluation of the first moment of Delta u_v + Delta d_v which is found to be equal to 0.40 +- 0.07 (stat.) +- 0.05 (syst.) over the measured range of x at Q^2 = 10 (GeV/c)^2. When combined with the first moment of g_1^d previously measured …
Implementation of Universal Digital Architecture using 3D-NoC for Mobile Terminal
2014
International Conference on Control, Decision and Information Technologies (CoDIT), Ecole Natl Ingenieurs Metz, Metz, FRANCE, NOV 03-05, 2014; International audience; The need to integrate multiple wireless communication protocols into a single low-cost flexible hardware platform is prompted by the increasing number of emerging communication protocols and applications in modern embedded systems. So the current challenge is to design of new digital architectures, in addition to its ability to take over of many functions. In this paper we have identified similarities between the despreader units in Rake receiver and the processor element in FFT-SDF (Fast Fourier Transform-Single path Delay Fe…
I rapporti fra i reati di induzione, favoreggiamento e sfruttamento della prostituzione minorile. Per la Cassazione l'art. 600 bis c.p. è «disposizio…
2021
La sentenza in epigrafe si segnala all'attenzione perché afferma il principio secondo cui le condotte criminose di induzione, favoreggiamento o sfruttamento della prostituzione minorile, di cui all'art. 600 bis, 1° comma, nn. 1 e 2, c.p., non costituiscono unico delitto, bensì più reati fra di loro concorrenti, in quanto caratterizzati da elementi materiali differenti in rapporto alla condotta e all'evento. Sulla questione esiste da tempo una certa diversità di vedute fra il prevalente orientamento giurisprudenziale e la dottrina. Il mero dato formale della intervenuta distinzione numerica nel testo della fattispecie non può essere da solo sufficiente a giustificare la moltiplicazione delle…
The Italian multiple sclerosis register
2019
The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational studies based on register data, as they have the potential to answer the questions that are most relevant to daily treatment decision-making. In 2014, the Italian MS Foundation, in collaboration with the Italian MS clinical centers, promoted and funded the creation of the …
Prognostic indicators in pediatric clinically isolated syndrome
2017
To assess prognostic factors for a second clinical attack and a first disability worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of Multiple Sclerosis (MS) patients. Objective: To assess prognostic factors for a second clinical attack and a first disability-worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of multiple sclerosis (MS) patients. Methods: A cohort of 770 pCIS patients was followed up for at least 10 years. Cox proportional hazard models and Recursive Partitioning and Amalgamation (RECPAM) tree-regression were used to analyze data. Results: In pCIS, female sex and a multifocal onset were risk factors for a second clinical att…
Imperative and Elective Indications for Nephron-Sparing Surgery for Renal Tumors: Long-Term Oncological Follow-Up
2010
INTRODUCTION: Nephron-sparing surgery (NSS) is mandatory for patients with renal tumors in both kidneys or in a solitary kidney in order to preserve renal function (imperative indication). NSS has also become the gold standard (elective indication) for small unilateral renal tumors (< 4 cm) with a normal contralateral kidney. We report the oncological long-term follow-up of NSS of our own series and discuss the results of the current literature. PATIENTS AND METHODS: From 1979 until 2006, a total of 851 patients was treated at our institu-tion by NSS. The mean tumor diameter was 3 cm (0.5-11 cm) for elective cases and 4.2 cm (1.2-11 cm) for imperative cases. The median follow-up for electiv…
Risk Preference Heterogeneity and Multiple Demand for Insurance
2010
We examined the relationship between unobserved risk preferences and four insurance purchase decisions: health Medigap insurance, long-term insurance, life insurance and annuity. Standard economic theory assumes that individuals take decision over a set of risky domains according to their own risk preferences which are stable across decision contexts. This assumption of context-invariant risk preference has caused debate in the literature concerning its validity. Using data from the Health and Retirement Study, we exploit latent class analysis to identify conditional on predicted and realized risk how heterogeneity in risk preferences affects multiple insurance demand. Our results provide e…