Search results for " objectives"
showing 10 items of 78 documents
Headquarters’ Control Capacity and the Choice of R&D Organizational Forms Abroad
2013
International audience; Recently, regarding globalization, the decentralization of R&D activities abroad by multinational companies (MNCs) has become important in developed countries. However, academic research has not given this topic sufficient attention. This paper explains how the efficiency of control and incentive mechanisms may affect the choice of organizational forms by MNCs that decentralize their R&D activities abroad. We identify five main organizational forms: wholly owned green-field subsidiary, wholly owned acquired subsidiary, joint venture, cross-licensing agreements, and unilateral licensing agreements. A questionnaire addressed to the R&D managers of American and European…
Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and …
2016
WOS: 000393031600001
Interactive Nonlinear Multiobjective Optimization Methods
2016
An overview of interactive methods for solving nonlinear multiobjective optimization problems is given. In interactive methods, the decision maker progressively provides preference information so that the most satisfactory Pareto optimal solution can be found for her or his. The basic features of several methods are introduced and some theoretical results are provided. In addition, references to modifications and applications as well as to other methods are indicated. As the role of the decision maker is very important in interactive methods, methods presented are classified according to the type of preference information that the decision maker is assumed to provide. peerReviewed
Surrogate-assisted evolutionary biobjective optimization for objectives with non-uniform latencies
2018
We consider multiobjective optimization problems where objective functions have different (or heterogeneous) evaluation times or latencies. This is of great relevance for (computationally) expensive multiobjective optimization as there is no reason to assume that all objective functions should take an equal amount of time to be evaluated (particularly when objectives are evaluated separately). To cope with such problems, we propose a variation of the Kriging-assisted reference vector guided evolutionary algorithm (K-RVEA) called heterogeneous K-RVEA (short HK-RVEA). This algorithm is a merger of two main concepts designed to account for different latencies: A single-objective evolutionary a…
Global, regional, and national levels and causes of maternal mortality during 1990-2013: A systematic analysis for the Global Burden of Disease Study…
2014
BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.METHODS: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basi…
The DArk Matter Particle Explorer mission
2017
The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calib…
APROS-NIMBUS: Dynamic Process Simulator and Interactive Multiobjective Optimization in Plant Automation
2013
Abstract Virtual commissioning of chemical plants often involves a dynamic simulator and an optimization method. This paper demonstrates the integration of APROS, a dynamic process simulator and IND-NIMBUS, an interactive multiobjective optimization software. We implement a multiobjective concentration control problem in APROS involving conflicting objectives and employ a decision maker to interact with IND-NIMBUS and express his preference information to finally obtain his most preferred solution. The results of this study show that APROS and IND-NIMBUS can be integrated and an interactive multiobjective optimization method can help the decision maker in exploring trade-offs among conflict…
Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement
2019
Rationale: Immune checkpoint inhibitors (ICIs) have revolutionized cancer care but are associated with unique adverse events, including potentially life-threatening pneumonitis. The diagnosis of ICI-pneumonitis is increasing; however, the biological mechanisms, clinical and radiologic features, and the diagnosis and management have not been well defined. Objectives: To summarize evidence, identify knowledge and research gaps, and prioritize topics and propose methods for future research on ICI-pneumonitis. Methods: A multidisciplinary group of international clinical researchers reviewed available data on ICI-pneumonitis to develop and refine research questions pertaining to ICI-pneumonitis.…
Branch-and-Cut-and-Price for the Vehicle Routing Problem with Time Windows and Convex Node Costs
2019
Two critical yet frequently conflicting objectives for logistics and transportation service companies are improving customer satisfaction and reducing transportation cost. In particular, given a network of customer requests with preferred service times, it is very challenging to find vehicle routes and service schedules simultaneously that respect all operating constraints and minimize the total transportation and customers’ inconvenience costs. In this paper, we introduce the vehicle routing problem with time windows and convex node costs (VRPTW-CNC), in which we model each customer’s inconvenience cost as a convex function of the service start time at that customer. The VRPTW-CNC combine…
Presentazione
2013
Il testo propone un articolato commento alle posizioni teoriche e alle linee di ricerca progettuale espresse da Michele Argentino, professore ordinario di Design a Palermo circa la necessità di riconquistare il ruolo sociale alla creatività individuale, riprendendosi il desiderio di diventare nuovamente "Homo Faber". Il testo inoltre presenta gli obiettivi della nuova collana scientifica - diretta dall'autrice - dal Titolo " Design e Contesti": intercettare ambiti di ricerca trasversali alle discipline del progetto, favorire gli intrecci tra idee progettuali e percorsi di innovazione socio-culturale, sviluppare nuove strategie produttive compatibili con i diversi aspetti della sostenibilità.