Search results for " osteonecrosis of the jaw"

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Comment on “Medication-Related Osteonecrosis of the Jaw (MRONJ)” by Elie M. Ferneini in the Section “Simply Put: JOMS Information for Patients”

2021

We read with great interest the contribute to the section “Simply Put: JOMS Information for Patients” named “Medication-Related Osteonecrosis of the Jaw (MRONJ)” by Elie M. Ferneini.

Comment medication-related osteonecrosis of the jaw mronj
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Conservative surgical treatment of medication-related osteonecrosis of the jaws with Leukocyte-Platelet Rich Fibrin: preliminary results at nine mont…

2019

Conservative surgical treatment medication-related osteonecrosis of the jaws Leukocyte-Platelet Rich Fibrin
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Could the Combined Administration of Bone Antiresorptive Drug, Taxanes, and Corticosteroids Worsen Medication Related Osteonecrosis of the Jaws in Ca…

2018

The study presents a report of 58 metastatic cancer patients who developed osteonecrosis of the jaws after being treated with zoledronic acid and taxanes, plus corticosteroids. A retrospective analysis of data registered in the archives of two Italian osteonecrosis of the jaws treatment centers, who are based at the University of Messina and at the University of Palermo, was performed in order to study, in these patients, demographic data and characteristics such as frequency of cancer location, lines of therapy, frequency of cancer drugs, presence/absence of oral trigger, number, location, and stage of jaw osteonecrosis. It was found that the majority of patients developed advanced stages …

DrugGenetics and Molecular Biology (all)Malemedicine.medical_specialtyExacerbationArticle SubjectImmunology and Microbiology (all)media_common.quotation_subjectlcsh:MedicineClinical manifestationBiochemistryGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineAdrenal Cortex HormonesInternal medicineNeoplasmsmedicineHumansDrug InteractionsStage (cooking)media_commonRetrospective StudiesBiochemistry Genetics and Molecular Biology (all)General Immunology and MicrobiologyBone Density Conservation AgentsDiphosphonatesbusiness.industrylcsh:ROsteonecrosisSoft tissueCancer030206 dentistryGeneral Medicinemedicine.diseaseZoledronic acidBiochemistry Genetics and Molecular Biology (all) Immunology and Microbiology (all)Italy030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawFemaleTaxoidsbusinessOsteonecrosis of the jawBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)medicine.drugResearch ArticleBioMed Research International
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The dental management of patients at risk of medication-related osteonecrosis of the jaw: New paradigm of primary prevention

2018

Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is a potentially painful and debilitating condition that can considerably affect the quality of life of patients. Furthermore, even if its epidemiology and pathogenesis have still not been fully clarified, several risk factors related to MRONJ have been recognized in prevention protocols. Three main risk factors are as follows: (i) the type of ONJ-related medications: antiresorptive (e.g., Bisphosphonates, Denosumab) and antiangiogenic drugs (e.g., Bevacizumab, Sunitinib); (ii) the category of patient at MRONJ risk: cancer versus non-cancer patient; (iii) the typ…

Genetics and Molecular Biology (all)medicine.medical_specialtyBevacizumabImmunology and Microbiology (all)lcsh:MedicineAngiogenesis InhibitorsReview ArticleBiochemistryGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineQuality of lifeSettore MED/28 - Malattie OdontostomatologicheNeoplasmsOral and maxillofacial pathologyEpidemiologymedicineHumansIntensive care medicineAdverse effectBiochemistry Genetics and Molecular Biology (all)Bone Density Conservation AgentsDiphosphonatesGeneral Immunology and MicrobiologySunitinibbusiness.industrylcsh:R030206 dentistryGeneral Medicinemedicine.diseaseDenosumab030220 oncology & carcinogenesisOsteoporosisBisphosphonate-Associated Osteonecrosis of the JawbusinessOsteonecrosis of the jawBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)medicine.drug
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Knowledge of bisphosphonate-related osteonecrosis of the Jawsamong Mexican dentists

2017

Background Bisphosphonate-related osteonecrosis is an infrequent but potentially serious complication. Its treatment remains complex, and in some cases can be mutilating. Prevention, a correct diagnosis and opportune management are crucial. Material and Methods A cross-sectional study was made, interviewing 410 dentists with the aim of assessing their knowledge of the subject. Results Practically all of the dental professionals (99.7%) were found to lack sufficient knowledge of the prevention, diagnosis and management of bisphosphonate-related osteonecrosis. Conclusions Actions including increased diffusion in the professional media and inclusion of the subject in training programs are need…

Health Knowledge Attitudes Practicemedicine.medical_specialtyCross-sectional studymedicine.medical_treatmentMEDLINEDentistryHealth knowledge03 medical and health sciences0302 clinical medicineRisk FactorsmedicineHumansIntensive care medicineSelf reportMexicoGeneral Dentistrybusiness.industryResearch030206 dentistryBisphosphonateMedically compromised patients in Dentistry:CIENCIAS MÉDICAS [UNESCO]Cross-Sectional StudiesOtorhinolaryngologyDentistry030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASBisphosphonate-Associated Osteonecrosis of the JawSurgerySelf ReportbusinessMedicina Oral Patología Oral y Cirugia Bucal
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Oxidative stress in bisphosphonate-related osteonecrosis of the jaws

2013

Objectives To analyze whether oxidative stress (OS) changes are present in patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ) versus controls. Materials and Methods Oxidative stress was analyzed in serum and unstimulated saliva of three groups: Group 1 consisted of 24 patients who had been treated with intravenous bisphosphonates (ivBPs) and developed BRONJ, group 2 consisted of 20 patients who had received ivBPs and did not develop BRONJ, and group 3 comprised 17 control subjects. Reduced glutathione (GSH), malondialdehyde (MDA), oxidized glutathione (GSSG), and 8–oxo-7,8-dihydro-2-deoxyguanosine (8-oxo-dG) levels, as well as the GSSG/GSH ratio, were measured. Results Me…

MaleCancer ResearchSalivaOral Hygiene Indexmedicine.medical_treatmentmedicine.disease_causeGastroenterologychemistry.chemical_compoundfluids and secretionsAdrenal Cortex HormonesMalondialdehydeDiphosphonatesGlutathione DisulfideDental Plaque IndexMiddle AgedMalondialdehydeGlutathione8-Hydroxy-2'-DeoxyguanosinePeriodonticsAdministration IntravenousBisphosphonate-Associated Osteonecrosis of the JawFemaleOral SurgeryMultiple Myelomamedicine.medical_specialtyAntineoplastic AgentsBreast NeoplasmsPathology and Forensic MedicineSex FactorsInternal medicinemedicineHumansSalivaAgedBisphosphonate-associated osteonecrosis of the jawDMF Indexbusiness.industryDeoxyguanosineGlutathioneBisphosphonatemedicine.diseaseSurgeryOxidative StressOtorhinolaryngologychemistryCase-Control StudiesGlutathione disulfideOsteonecrosis of the jawbusinessBiomarkersOxidative stressJournal of Oral Pathology & Medicine
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Surgical evaluation of panoramic radiography and cone beam computed tomography for therapy planning of bisphosphonate-related osteonecrosis of the ja…

2015

The purpose of this retrospective study was to compare the clinical significance of panoramic radiography (orthopantomography [OPTG]) and cone beam computed tomography (CBCT) for therapy planning of bisphosphonate-related osteonecrosis of the jaw (BRONJ) by surgeons.Using standardized questionnaire, eight maxillofacial surgeons evaluated intraoral photographs of the clinical situation of 14 patients with BRONJ as well as the corresponding radiographic images (OPTG, CBCT). The presence of five typical BRONJ signs (bone-remodeling, periosteal reaction, osteosclerosis, sequestra, and continuity of cortical bone) was evaluated with OPTG and CBCT. The influence of radiologic information on thera…

MaleCone beam computed tomographymedicine.medical_specialtyRadiographymedicine.medical_treatmentDecision MakingPeriosteal reactionTherapy planningPatient Care PlanningPathology and Forensic Medicine03 medical and health sciences0302 clinical medicinestomatognathic systemSurveys and QuestionnairesRadiography PanoramicmedicineHumansRadiology Nuclear Medicine and imagingDentistry (miscellaneous)Clinical significanceAgedRetrospective StudiesAged 80 and overbusiness.industryRetrospective cohort study030206 dentistryCone-Beam Computed TomographyMiddle Agedrespiratory systemBisphosphonatemedicine.disease030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgeryRadiologyOral SurgerybusinessOsteonecrosis of the jawOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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Up to a quarter of patients with osteonecrosis of the jaw associated with antiresorptive agents remain undiagnosed

2014

AbstractRecent data suggest that the traditional definition of bisphosphonate-associated osteonecrosis of the jaw (ONJ) may exclude patients who present with the non-exposed variant of the condition. To test the hypothesis that a proportion of patients with ONJ remain undiagnosed because their symptoms do not conform to the traditional case definition, we did a secondary analysis of data from MISSION (Multicentre study on phenotype, definition and classification of osteonecrosis of the jaws associated with bisphosphonates), a cross-sectional study of a large population of patients with bisphosphonate-associated ONJ who were recruited in 13 European centres. Patients with exposed and non-exp…

MaleDelayed DiagnosisSettore MED/50 - Scienze Tecniche Mediche ApplicateAntineoplastic AgentsOsteonecrosis; Jawbones; BisphosphonatesOsteonecrosis; Jawbones;BisphosphonatesSettore MED/29 - Chirurgia MaxillofaccialeSettore MED/28 - Malattie OdontostomatologicheOsteonecrosis; Jawbones; Bisphosphonates;JawbonesBisphosphonateHumansDiagnostic Errorsosteonecrosis; jawbones; bisphosphonatesPeriodontal DiseasesAgedPain MeasurementBone Density Conservation AgentsOsteonecrosisBisphosphonatesMiddle AgedCross-Sectional StudiesPhenotypeOtorhinolaryngologyTooth DiseasesTooth ExtractionOsteonecrosiOsteoporosisSurgeryBisphosphonate-Associated Osteonecrosis of the JawFemaleOral SurgeryJawbone
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Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Stu…

2018

Introduction. The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods. We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. Results. We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up…

MaleGenetics and Molecular Biology (all)medicine.medical_specialtyLongitudinal studyArticle SubjectImmunology and Microbiology (all)medicine.medical_treatmentSettore MED/19 - Chirurgia Plasticalcsh:MedicineLasers Solid-StateSettore MED/08 - Anatomia PatologicaBiochemistryGeneral Biochemistry Genetics and Molecular BiologySettore MED/01 - Statistica Medica03 medical and health sciences0302 clinical medicineSettore MED/28 - Malattie OdontostomatologichemedicineHumansLongitudinal StudiesProspective StudiesSurgical treatmentProspective cohort studyAgedAged 80 and overSurgical approachBiochemistry Genetics and Molecular Biology (all)Bone Density Conservation AgentsDiphosphonatesGeneral Immunology and MicrobiologyPlatelet-Rich Plasmabusiness.industrylcsh:RCancer030206 dentistryGeneral MedicineBisphosphonatemedicine.diseaseSurgery030220 oncology & carcinogenesisPlatelet-rich plasmaClinical StudyBisphosphonate-Associated Osteonecrosis of the JawFemaleOsteonecrosis of the jawbusinessBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)
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Extraction socket healing in rats treated with bisphosphonate: Animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma pati…

2010

Aim: The aim of this study is to replicate both clinical and histological presentation of bisphosphonate induced osteonecrosis of the jaws (BONJ) in an animal model of the disease state. Successful recapitulation of a BONJlike indication in an animal model will be useful for studying pathogenesis, as well as prevention and treatment strategies for BONJ. Materials and Methods: Eighty (80) rats were prospectively and randomly divided into two groups; control group(40) and study group(40). All animals in study group, injected with a dose of 1 mg/kg dexamethasone (DX) subcutaneously on day 7, 14, or 21; and 1, 2, or 3 doses of 7.5 ?g/kg zoledronic acid (ZA) subcutaneously administered to coinci…

MaleMolarmedicine.medical_specialtymedicine.medical_treatmentFibrosismedicineAnimalsHumansRats WistarTooth SocketGeneral DentistryMultiple myelomaDexamethasoneDental alveolusWound HealingDiphosphonatesbusiness.industryBisphosphonate:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseRatsSurgeryDisease Models AnimalZoledronic acidOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASTooth ExtractionPopulation studyBisphosphonate-Associated Osteonecrosis of the JawSurgeryMultiple Myelomabusinessmedicine.drugMedicina Oral Patología Oral y Cirugia Bucal
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