Search results for " outcomes"

showing 10 items of 356 documents

Piloting Regional Innovation or Much Ado about Nothing?—Evaluating the R&D Policy Initiative of Nordland, Norway

2014

AbstractThis article evaluates the results of almost a decade of experience with regional R&D development and implementation for enhanced innovation in the county of Nordland, Norway. Following a 2002 national devolution initiative, the county of Nordland was the first among Norwegian counties to coin and implement a distinct R&D policy for business-related innovation and development. This was done by setting up a broad regional partnership, framing a regional strategy and by coordinating substantial budgetary resources to implement the strategy. The evaluation describes the results of this process as ambiguous. This article looks at the process from three perspectives. First, we look at th…

Regional strategyFraming (social sciences)NothingBusiness communityGeneral partnershipPolitical scienceGeography Planning and DevelopmentAltered behaviourlanguageNorwegianPublic administrationPolicy outcomeslanguage.human_languageEuropean Planning Studies
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Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Resear…

2021

Abstract Background Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse the differential clinical course. Methods We performed a hierarchical cluster analysis based on Ward’s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results A total of 9363 were available for this analysis. We identified three …

RegistrieResearch Reportmedicine.medical_specialtyMajor adverse outcomeCardiovascular risk factorsCluster analysisRisk FactorsInternal medicineClinical phenotypeAtrial FibrillationEpidemiologyHumansMedicineRegistriesCluster analysiAtrial fibrillation; Clinical management; Clinical phenotypes; Cluster analysis; Major adverse outcomes; Humans; Phenotype; Registries; Research Report; Risk Factors; Atrial FibrillationClinical managementbusiness.industryProportional hazards modelRisk FactorHazard ratioRAtrial fibrillationClinical phenotypesMajor adverse outcomesGeneral Medicinemedicine.diseaseAtrial fibrillationConfidence intervalPhenotypeCohortMedicineObservational studybusinessResearch ArticleHumanBMC Medicine
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Impact of prognostic factors on long-term outcomes in metastatic breast cancer (MBC) patients (pts) receiving bevacizumab (B) plus paclitaxel as firs…

2014

e12007 Background: B combined with chemotherapy (CT) significantly improves progression-free survival (PFS) and response rate (RR) vs CT alone in the first-line treatment of HER2-negative MBC. In a...

Response rate (survey)OncologyCancer Researchmedicine.medical_specialtyChemotherapyBevacizumabbusiness.industryFirst linemedicine.medical_treatmentMedizinmedicine.diseaseMetastatic breast cancerSurgerychemistry.chemical_compoundOncologyPaclitaxelchemistryInternal medicinemedicineLong term outcomesCytotoxic T cellskin and connective tissue diseasesbusinessneoplasmsmedicine.drugJournal of Clinical Oncology
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Rehabilitation approach in robot assisted total knee arthroplasty: an observational study

2023

Abstract Background The purpose of this study is to evaluate the impact of total knee arthroplasty (TKA) with the aid of Navio Robot, comparing it with standard prosthetic surgery on the functional outcomes of patients after an intensive rehabilitation program. Method A case–control observational study was conducted on patients undergoing TKA for severe KOA. All patients underwent the same intensive hospital rehabilitation program of 14 daily sessions lasting 3 h. The following rating scales were administered: Numeric Rating Scale (NRS), Knee Society Score (KSS) and 12-Item Short Form Survey scale. Patient assessments were performed 1 week post-surgery (T0), 1 month post-surgery (T2), and 3…

RheumatologyKeywords Knee arthroplasty Rehabilitation Knee osteoarthritis NAVIO OutcomesOrthopedics and Sports MedicineBMC Musculoskeletal Disorders
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The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes

2015

Background. Critically ill patients appear to be at high risk of developing deep vein thrombosis (DVT) and pulmonary embolism during their stay in the intensive care unit (ICU). However, little is known about the clinical course of venous thromboembolism in the ICU setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of DVT on hospital and ICU stay, duration of mechanical ventilation and mortality in critically ill patients. We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the ICU setting. Materials and methods. MEDLINE and EMBASE databases were searched up…

RiskCritical IllnessIntensive Care UnitCritically ill patients; Deep vein thrombosis; Meta-analysis; Outcomes; Cohort Studies; Hospital Mortality; Humans; Intensive Care Units; Length of Stay; Pulmonary Embolism; Randomized Controlled Trials as Topic; Research Design; Respiration Artificial; Risk; Thrombophilia; Treatment Outcome; Venous Thrombosis; Critical Illness; Hematology; Immunology and AllergyReviewDeep Vein Thrombosis Critically Ill Patients outcomes metanalysisCohort StudiesDeep vein thrombosiImmunology and AllergyHumansThrombophiliaMeta-analysiVenous ThrombosiHospital MortalityOutcomeRandomized Controlled Trials as TopicVenous ThrombosisHematologyLength of StayRespiration ArtificialIntensive Care UnitsTreatment OutcomeResearch DesignCritical IllneCritically ill patientCohort StudiePulmonary EmbolismHuman
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Xenon treatment improves short-term and long-term outcomes in a rodent model of traumatic brain injury

2018

Science & TechnologyTraumatic brain injurybusiness.industrySITE1103 Clinical SciencesRodent modelmedicine.diseaseCOMPETITIVE-INHIBITIONTerm (time)D-ASPARTATE RECEPTORAnesthesiology and Pain MedicineAnesthesiologyAnesthesiamedicineLong term outcomesbusinessLife Sciences & BiomedicineBritish Journal of Anaesthesia
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Psychometric properties of the Finnish version of the Young Person's Clinical Outcomes in Routine Evaluation (YP-CORE) questionnaire.

2017

An increasing need exists for suitable measures to evaluate treatment outcome in adolescents. YP-CORE is a pan-theoretical brief questionnaire developed for this purpose, but it lacks studies in different cultures or languages.To explore the acceptability, factor structure, reliability, validity, and sensitivity to change of the Finnish translation of YP-CORE.The study was conducted at the Department of Adolescent Psychiatry, Helsinki University Central Hospital. A Finnish translation was prepared by a team of professionals and adolescents. A clinical sample of 104 patients was asked to complete the form together with BDI-21 and BAI, and 92 of them filled the forms again after a 3-month tre…

Self-assessmentCross-Cultural ComparisonMale050103 clinical psychologymedicine.medical_specialtySelf-AssessmentPsychometricsAdolescentPsychometricsConcurrent validitypsychometric properties03 medical and health sciencesoutcome measures0302 clinical medicineSurveys and QuestionnairesYP-COREOutcome Assessment Health CaremedicineHumans0501 psychology and cognitive sciencesPsychiatryReliability (statistics)ta515Finlandbusiness.industryMental Disorders05 social sciencesBeck Depression InventoryYoung Person’s Clinical Outcomes in Routine EvaluationReproducibility of ResultsquestionnairesTranslatingCross-cultural studiesroutine evaluationConfirmatory factor analysisclinical outcomes3. Good health030227 psychiatryPsychiatry and Mental healthAnxietyadolescenceFemalemedicine.symptombusinessNordic journal of psychiatry
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Leveraging Collaborative Governance: How Co-production Contributes to Outcomes and Public Value in a Small Town

2020

Collaborative governance is increasingly considered an effective approach to improve outcomes and public value. This chapter focuses on co-production as an instrument to implement collaborative governance at local level. It is not uncommon that small towns develop co-production processes to deliver cultural and touristic services. Out of a literature review, the study develops a Dynamic Multidimensional Performance Management framework to explore the impact of co-production on community outcomes. To this end, this chapter discusses the case “Museo Civico di Castelbuono (MCC)”,which concerns the co-production process of the guided tour of the museum’s venue. The resulting model provides insi…

Service (business)Knowledge managementPerformance managementbusiness.industryProcess (engineering)Corporate governanceProduction (economics)Collaborative Governance Co-production of Public Service Performance Management Outcomes cultural serviceCollaborative governancePublic valueAction researchbusinessCollaborative Governance
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Prospettive di riforma della tutela penale dell'ambiente nel diritto europeo e sovranazionale

2021

Il saggio descrive le prospettive di riforma della normativa penale ambientale, di recente delineatesi tanto a livello internazionale, quanto in ambito europeo. Pur non spingendosi sino a prevedere i possibili esiti delle dinamiche in corso, il contributo non rinuncia ad analizzarne luci ed ombre, anche alla luce delle difficoltà di tipizzazione delle fattispecie incriminatrici determinata dalla particolare complessità della materia ambientale.

Settore IUS/17 - Diritto PenaleThe essay describes the prospects of reform of environmental criminal law recently outlined both at international and European level. Although the contribution does not go so far as to predict the possible outcomes of the dynamics in progress it does not shy away from analysing the lights and shadows also in the light of the difficulties of typifying criminal offences determined by the particular complexity of environmental matters.
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Profiling the risk of hepatocellular carcinoma after long-term HCV eradication in patients with liver cirrhosis in the PITER cohort

2023

Background and aims: Severe liver disease markers assessed before HCV eradication are acknowledged to usually improve after the SVR. We prospectively evaluated, in the PITER cohort, the long-term HCC risk profile based on predictors monitored after HCV eradication by direct-acting antivirals in patients with cirrhosis. Methods: HCC occurrence was evaluated by Kaplan-Meier analysis. Cox regression analysis identified the post-treatment variables associated with de-novo HCC; their predictive power was presented in a nomogram. Results: After the end of therapy (median follow-up:28.47 months), among 2064 SVR patients, 119 (5.8%) developed de-novo HCC. The HCC incidence was 1.90%, 4.21%, 6.47% a…

Settore MED/12Real-life cohort.HepatologyDirect-acting antiviral; HCC; Long term outcomes; Predictive factors; Real-life cohortGastroenterologyReal-life cohortLong term outcomeHCCPredictive factorDirect-acting antiviralLong term outcomesPredictive factors
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