Search results for " panel"
showing 10 items of 190 documents
First Nationwide Molecular Screening Program in Spain for Patients With Advanced Breast Cancer: Results From the AGATA SOLTI-1301 Study
2021
Anàlisi de seqüències d'ADN; Subtipus PAM50; Genètica molecular Análisis de secuencias de ADN; Subtipo PAM50; Genética molecular DNA sequence analyses; PAM50 subtype; Molecular genetic Background: The SOLTI-1301 AGATA study aimed to assess the feasibility of a multi-institutional molecular screening program to better characterize the genomic landscape of advanced breast cancer (ABC) and to facilitate patient access to matched-targeted therapies in Spain. Methods: DNA sequencing of 74 cancer-related genes was performed using FFPE tumor samples in three different laboratories with three different gene panels. A multidisciplinary advisory board prospectively recommended potential targeted trea…
Impact of deleterious variants in other genes beyond BRCA1/2 detected in breast/ovarian and pancreatic cancer patients by NGS-based multi-gene panel …
2021
Background Hereditary breast cancer (BC), ovarian cancer (OC), and pancreatic cancer (PC) are the major BRCA-associated tumours. However, some BRCA1/2-wild-type (wt) patients with a strong personal and/or family history of cancer need a further genetic testing through a multi-gene panel containing other high- and moderate-risk susceptibility genes. Patients and methods Our study was aimed to assess if some BC, OC, or PC patients should be offered multi-gene panel testing, based on well-defined criteria concerning their personal and/or family history of cancer, such as earliness of cancer onset, occurrence of multiple tumours, or presence of at least two or more affected first-degree relativ…
Scalable Bio Marker Combinations for Early Stroke Diagnosis: A Systematic Review
2021
Background: Acute stroke treatment is a time-critical process in which every minute counts. Laboratory biomarkers are needed to aid clinical decisions in the diagnosis. Although imaging is critical for this process, these biomarkers may provide additional information to distinguish actual stroke from its mimics and monitor patient condition and the effect of potential neuroprotective strategies. For such biomarkers to be effectively scalable to public health in any economic setting, these must be cost-effective and non-invasive. We hypothesized that blood-based combinations (panels) of proteins might be the key to this approach and explored this possibility through a systematic review.Metho…
Evaluation and application of Opuntia ficus-indica insulation panel
2015
Today the attention to the building sustainability issue is increasingly important, because of the major responsibility of the buildings field in the environmental degradation: both in terms of energy consumption from non-renewable sources and the raw materials impoverishment. In addition, the level of comfort required by users are growing and the thermal insulation of buildings becomes the key element in the reduction of energy consumption and C02 emissions, both in the case of new construction and existing ones. The thermal insulation of buildings is the key element in the reduction of energy consumption and C02 emissions due to the cooling of building interiors, both in the case of new c…
A review of DEA models when the internal structure of the decision making units is considered
2005
Classical Data Envelopment Analysis (DEA) models consider each Decision Making Unit (DMU), whose relative efficiency they evaluate, as a "black box", i.e., its internal structure is disregarded. The paper presents a comprehensive framework of the most advanced theoretical findings in DEA when the internal structure of the. DMUs is taken into account, thus giving directions for novel applications of such methodology and introducing it as a powerful toot for complex processes performance evaluation.
Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and …
2016
WOS: 000393031600001
Effects of a Travel Behaviour Change Program on Sustainable Travel
2018
The main objective of the present study is to analyse the effect of a Travel Behaviour Change Program (TBCP) based on health improvement actions, in relation to a potential for an increase in walking and cycling, with reference to particular groups of people defined according to sociodemographics. A TBCP consisting of three persuasion actions based on health improvements was planned and executed in Valencia (Spain). A two-wave panel survey was used to study the effects of taking part in the TBCP. The panel survey collected data related to activity-travel scheduling process before and after the execution of the TBCP. To study the influence of participating in the TBCP, respondents were separ…
Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: A joint ESA/ESICM guideline.
2020
Hypoxaemia is a potential life-threatening yet common complication in the peri-operative and periprocedural patient (e.g. during an invasive procedure at risk of deterioration of gas exchange, such as bronchoscopy). The European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM) developed guidelines for the use of noninvasive respiratory support techniques in the hypoxaemic patient in the peri-operative and periprocedural period. The panel outlined five clinical questions regarding treatment with noninvasive respiratory support techniques [conventional oxygen therapy (COT), high flow nasal cannula, noninvasive positive pressure ventilation (NIPPV) a…
Stability of moving viscoelastic panels interacting with surrounding fluid
2012
We study a model describing the out-of-plane vibrations of an axially moving viscoelastic panel submerged in flowing fluid. The panel is assumed to travel at a constant velocity between two fixed supports, and it is modeled as a flat panel made of viscoelastic Kelvin-Voigt material. The fluid flow is modeled with the help of the added mass coefficients. The resulting dynamic equation is a partial differential equation of fifth order in space. Five boundary conditions are set for the studied problem. The behavior of the panel is analyzed with the help of its eigenvalues (eigenfrequencies). These characteristics are studied with respect to the velocity of the panel. In our study, we have incl…
High Wage Workers Match with High Wage Firms: Clear Evidence of the Effects of Limited Mobility Bias
2012
Positive assortative matching implies that high productivity workers and firms match together. However, there is almost no evidence of a positive correlation between the worker and firm contributions in two-way fixed-effects wage equations. This could be the result of a bias caused by standard estimation error. Using German social security records we show that the effect of this bias is substantial in samples with limited inter-firm movement. The correlation between worker and firm contributions to wage equations is unambiguously positive.