Search results for " proline"
showing 8 items of 18 documents
Salivary properties involved in astringency sensitivity in human differ as a function of age
2022
Astringency is an important sensory characteristic of foods and beverages containing polyphenols. However, astringency perception in elderly people is not documented. Current hypothesis on astringency mechanism involved aggregation of the mucosal pellicle by tannins and its protective role by salivary proteins in particular proline rich-proteins (PRPs). The aim of the present work was to evaluate sensitivity to astringency in function of age and saliva (flow and composition). Fifty-four panelists including (30 elderlies and 24 young) participated in this study. Astringency was evaluated by 2-Alternative Forced Choice procedure. For salivary PRPs, a western blot methodology was set up to eva…
Toward More Efficient Organocatalysts
2011
Prolidase in the Marine Sponge Suberites domuncula: Enzyme Activity, Molecular Cloning, and Phylogenetic Relationship
1999
: The enzyme prolidase hydrolyzes the peptide bond that involves the imino nitrogen of proline or hydroxyproline; hence, it catalyzes the final step in collagen degradation. From mammals it is known that this enzyme plays a major role in the recycling of proline for collagen synthesis and can be considered to be essential for the control of cell growth. The dominant organic exoskeleton in sponges, especially in Demospongiae, is collagen and the collagen-related spongin. Here we demonstrate that crude extracts of the demosponge Suberites domuncula contain prolidase or prolidase-like activity. The complementary DNA encoding the putative prolidase was cloned from a library of the same animal. …
Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women
2014
AIM: To investigate the safety/efficacy of Boceprevirbased triple therapy in hepatitis C virus (HCV)-G1 menopausal women who were historic relapsers, partial-responders and null-responders. METHODS: In this single-assignment, unblinded study, we treated fifty-six menopausal women with HCV-G1, 46% F3-F4, and previous PEG-α/RBV failure (7% null, 41% non-responder, and 52% relapser) with 4 wk lead-in with PEG-IFNα2b/RBV followed by PEGIFNα2b/RBV+Boceprevir for 32 wk, with an additional 12 wk of PEG-IFN-α-2b/RBV if patients were HCV-RNA-positive by week 8. In previous null-responders, 44 wk of triple therapy was used. The primary objective of retreatment was to verify whether a sustained virolo…
Mass spectrometry for the study of protein-ligand interactions and supramolecular complexes: Application to an intrinsically disordered protein
2015
International audience
Asymmetric Aldol Reaction with Polystyrene-Supported Proline-Based Catalysts
2009
Stereoselective aldol reaction catalyzed by a highly recyclable polystyrene supported substituted prolinamide catalyst
2008
Polystyrene supported substituted prolinamide was used as catalyst in the aldol reaction between cyclohexanone or acetone and several substituted benzaldehydes in chloroform/water. This catalyst afforded aldol products in high yields and stereoselectivities, especially in the case of reactions performed with acetone. The catalyst was easily recovered by filtration and reused, after regeneration with formic acid, up to 22 times.
Contribution des interactions tanins - protéines salivaires dans la sensation d'astringence
2015
National audience