Search results for " regulation."

Protein Phosphorylation by Peroxisome Proliferators: Species-specific Stimulation of Protein Kinases and Its Role in PP-induced Transcriptional Activ…

1996

Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells

2009

The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. However, the underlying mechanisms and genetic programmes regulated by AhR to cause adverse effects but also to counteract poisoning are still poorly understood. Here we analysed the effects of two AhR ligands, benzo[a]pyrene (B[a]P), a DNA damaging tumour initiator and promotor and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a pure tumour promoter, on cell survival and on nucleotide excision repair (NER) gene expression. NER deals with so called "bulky" DNA adducts including those generated by enzymatically activated B[a]P. Therefore, t…

Heterogeneity within and between primary colorectal carcinomas and matched metastases as revealed by analysis of Ki-ras and p53 mutations

2004

Analysis of the genetic status of Ki-ras and p53 in primary colorectal carcinomas and matched colorectal liver metastasis from 30 patients reveals an overall heterogeneity both within and between the two tumoral tissues. Both genes were found mutated with a similar frequency in both tissues; however, identical mutations in primary tumor and matched metastasis were found less frequently in the case of the Ki-ras than the p53 gene. Only in three cases the same p53 and Ki-ras mutations found in the primary tumor were found also in the metastasis. In several metastatic specimens the DNA bearing a mutation detected also in the primary tumor appears significantly less abundant than the wild-type …

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

2018

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…

Net currents obtained from zero-average potentials in single amphoteric nanopores

2013

We have studied experimentally and theoretically the rectifying properties of a single asymmetric nanopore functionalized with amphoteric lysine groups and characterized the net current obtained with zero-average time dependent potentials. The pH-controlled rectification phenomena may be relevant to bio-electrochemistry, pH sensing and regulation, and energy conversion. (C) 2013 Elsevier B.V. All rights reserved.

Adolescents ́ career goals in social context

2013

Party autonomy regarding jurisdiction under the property regimes regulations

2021

The main accomplishment of the Property Regimes Regulations lies in their bringing more coherence into the cross-border family law adjudication. In the field of international jurisdiction, they strive to align the competence in couples? patrimony disputes to that in succession and in separation proceedings, or else to align the competence of the courts to the applicable law. These tendencies are clearly visible in the Regulations? provisions on choice of court agreements. Namely, the Regulations allow for such agreements, but severely limit parties? choice and the possible effects of these clauses. When succession or separation proceedings are pending, it is often only possible to institute…

Banche e struttura modulare dei sistemi di pagamento: una prospettiva di analisi economico-aziendale

2019

Technology is changing the fundamental economics of the payment industry, just as it has in many other industries. Technological innovations in payment systems have deep managerial and financial implications at firm, industry, and regulatory levels. This paper adopts a business management perspective of studies to examine the distinctive factors of the adoption and diffusion of technological innovation in the economics of payments systems. The main aim is to identify the relevant drivers which lead to modularity of payments systems in the financial industry. In this paper, I adopt a modular design methodology to identify the factors related to the interoperability of payments systems, to an…

Emociju regulācijas saistība ar uztverto sociālo atbalstu un sasniegumu motivāciju notiesātām personām ieslodzījumā

2019

Šī bakalaura darba mērķis bija noskaidrot, vai pastāv saistība starp emociju regulāciju, uztverto sociālo atbalstu un sasniegumu motivāciju notiesātām personām ieslodzījumā, analizējot teorētisko literatūru, jaunāko zinātnisko pētījumu rezultātus un veicot praktisku pētījumu. Tika izvirzīts pētījuma jautājums: Kādas ir sakarības starp emociju regulācijas, uztverto sociālā atbalsta un sasniegumu motivācijas rādītājiem notiesātām personām ieslodzījumā? Tāpat tika izvirzīti arī sekojoši papildjautājumi: 1) Kādas ir sakarības starp notiesātu personu ieslodzījumā uztvertā sociālā atbalsta rādītājiem, vecumu un attiecību statusu? 2) Kādas ir sakarības starp notiesātu personu ieslodzījumā sasniegu…

Characterization and transcription studies of a phytochelatin synthase gene from the solitary tunicate Ciona intestinalis exposed to cadmium.

2014

The major thiol-containing molecules involved in controlling the level of intracellular ROS in eukaryotes, acting as a nonenzymatic detoxification system, are metallothioneins (MTs), glutathione (GSH) and phytochelatins (PCs). Both MTs and GSH are well-known in the animal kingdom. PC was considered a prerogative of the plant kingdom but, in 2001, a phytochelatin synthase (PCS) gene was described in the nematode Caenorhabditis elegans; additional genes encoding this enzyme were later described in the earthworm Eisenia fetida and in the parasitic nematode Schistosoma mansoni but scanty data are available, up to now, for Deuterostomes. Here, we describe the molecular characteristics and transc…