Search results for " risk"
showing 10 items of 3823 documents
EMAS position statement: Predictors of premature and early natural menopause.
2019
Simoncini, Tommaso/0000-0002-2971-0079; Chung, Hsin-Fang/0000-0003-3261-5942; Mishra, Gita/0000-0001-9610-5904 WOS:000468709100014 PubMed ID: 31027683 Introduction: While the associations of genetic, reproductive and environmental factors with the timing of natural menopause have been extensively investigated, few epidemiological studies have specifically examined their association with premature (< 40 years) or early natural menopause (40-45 years). Aim: The aim of this position statement is to provide evidence on the predictors of premature and early natural menopause, as well as recommendations for the management of premature and early menopause and future research. Materials and methods…
Cement augmentation for trochanteric fracture in elderly: A systematic review()
2021
Abstract Background Cement augmentation of internal fixation of hip fracture has reported to improve fracture stability in osteoporotic hip fractures, reducing the risk of cut-out of the sliding screw through the femoral head. The purpose of present study was to perform a systematic literature review on the effects of augmentation technique in patients with osteoporotic hip fractures. Material and methods A comprehensive literature search was systematically performed to evaluate all papers published in English language included in the literature between January 2010 and July 2020, according to the PRISMA 2009 guidelines. In vivo and in vitro studies, case reports, review articles, cadaveric…
Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes
2018
The following article: Jung, R.E., Al-Nawas, B., Araujo, M., Avila-Ortiz, G., Barter, S., Brodala, N., ... Windisch, P. (2018). Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes. Clinical Oral Implants Research, 29(S16), 69-77, can be accessed at https://doi.org/10.1111/clr.13342. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Objectives: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient‐re…
Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms
2019
Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors describe the scarce preclinical and human research about the actions of CBD on the effects of stimulant drugs, mainly cocaine and methamphetamine (METH). Additionally, the possible mechanisms underlying the therapeutic potential of CBD on stimulant use disorders are reviewed. CBD has reversed toxicity and seizures induced by cocaine, behavioural sensitization induced by amphetamines, motivation to self-administer cocaine and METH, context- …
Is COVID‐19 infection more severe in kidney transplant recipients?
2021
International audience; There are no studies which have compared the risk of severe Covid-19 and related mortality between transplant recipients and non-transplant patients. We enrolled two groups of patients hospitalized for Covid-19, i.e., kidney transplant recipients from the French Registry of Solid Organ Transplant (n=306) and a single-center cohort of non-transplant patients (n=795). An analysis was performed among subgroups matched for age and risk factors for severe Covid-19 or mortality. Severe Covid-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death.Transplant recipients were younger and had more comorbidities compared to…
Mid- to Long-Term Outcomes of Cervical Disc Arthroplasty versus Anterior Cervical Discectomy and Fusion for Treatment of Symptomatic Cervical Disc Di…
2015
Purpose This study aimed to investigate the mid- to long-term outcomes of cervical disc arthroplasty (CDA) versus anterior cervical discectomy and fusion (ACDF) for the treatment of 1-level or 2-level symptomatic cervical disc disease. Methods Medline, Embase, and the Cochrane Central Register of Controlled Trials databases were searched to identify relevant randomized controlled trials that reported mid- to long-term outcomes (at least 48 months) of CDA versus ACDF. All data were analyzed by Review Manager 5.3 software. The relative risk (RR) and 95% confidence intervals (CIs) were calculated for dichotomous variables. The weighted mean difference (WMD) and 95%CIs were calculated for conti…
Impact of Glucose-Lowering Medications on Cardiometabolic Risk in Type 2 Diabetes
2019
Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular (CV) disease. Contributing pathophysiologic factors include endothelial dysfunction caused by excessive production of reactive oxygen species (ROS), increased activity of nuclear factor kB (NFkB), altered macrophage polarization, and reduced synthesis of endothelial progenitor cells (EPC). Consequently, there can be a potentially rapid progression of the atherosclerotic disease with a higher propensity to unstable plaque, leading to increased cardiovascular mortality. Management is aimed at prevention, early diagnosis, and treatment of hyperglycemia and vascular complications. Innovative therape…
Pacientu tiesību aizsardzības līdzekļi Latvijā
2019
Pacientu tiesības ir medicīnas tiesību apakšnozare, kura regulē attiecības starp pacientu, veselības pakalpojuma sniedzēju un valsti. Pacienta attiecības ar valsti ir atspoguļotas ne vien normatīvo aktu izdošanā un tiesību un pienākumu noteikšanā, bet arī pacientu tiesību aizsardzības līdzekļu izveidē un to darbības nodrošināšanā. Bakalaura darbā tiek apskatīts pacientu tiesību tvērums un pacientu kā īpašas sociālās grupas tiesiskais stāvoklis Latvijā un ārpus tās, noteikti pacientu tiesību aizskāruma izveidošanās mehānismi un iespējamās sekas. Tāpat ir veikts Latvijā pastāvošo pacientu tiesību aizsardzības līdzekļu izvērtējums, kur tiesu prakses apkopošanas rezultātā tiek secināts par to e…
What we learn about bipolar disorder from large-scale neuroimaging
2020
Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…
Izmaiņas augsta un vidēja riska gēnos gados jauniem melanomas pacientiem
2016
Melanoma ir ļaundabīgs ādas audzējs, kas attīstās vides un gēnu mijiedarbības rezultātā. Bakalaura darba mērķis bija izvērtēt izmaiņas augsta un vidēja riska gēnos melanomas pacientiem ar vairākiem primāriem audzējiem un gados jauniem (līdz 40 gadu vecumam) melanomas pacientiem Latvijā. Analīzē tika iekļauti seši pacienti ar vairākām primārām melanomām un 67 gados jauni melanomas pacienti. Tika izanalizēti pieci augsta (CDKN2A, CDK4, BAP1, POT1, TERT) un divi vidēja (MITF, MC1R) melanomas riska gēni. Atrastas trīs dažādas izmaiņas POT1 gēnā, no kurām viena ir jauna līdz šim neaprakstīta izmaiņa, viens rets MITF, divi CDKN2A un 8 dažādi MC1R gēnu polimorfismi. Izmaiņas BAP1, POT1 un CDK4 gēn…