Search results for " shape"
showing 10 items of 298 documents
The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability.
2008
Abstract Lysyl hydroxylase (LH) isoform 3 is a post-translational enzyme possessing LH, collagen galactosyltransferase (GT) and glucosyltransferase (GGT) activities. We have demonstrated that LH3 is found not only intracellularly, but also on the cell surface and in the extracellular space, suggesting additional functions for LH3. Here we show that the targeted disruption of LH3 by siRNA causes a marked reduction of both glycosyltransferase activities, and the overexpression of LH3 in HT-1080 cells increases hydroxylation of lysyl residues and the subsequent galactosylation and glucosylation of hydroxylysyl residues. These data confirm the multi-functionality of LH3 in cells. Furthermore, t…
Means of 2D and 3D Shapes and Their Application in Anatomical Atlas Building
2015
This works deals with the concept of mean when applied to 2D or 3D shapes and with its applicability to the construction of digital atlases to be used in digital anatomy. Unlike numerical data, there are several possible definitions of the mean of a shape distribution and procedures for its estimation from a sample of shapes. Most popular definitions are based in the distance function or in the coverage function, each with its strengths and limitations. Closely related to the concept of mean shape is the concept of atlas, here understood as a probability or membership map that tells how likely is that a point belongs to a shape drawn from the shape distribution at hand. We devise a procedur…
Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus
2006
Recent observations indicate that drugs of abuse, including alcohol and opiates, impair adult neurogenesis in the hippocampus. We have studied in rats the impact of cocaine treatment (20 mg/kg, daily, i.p.) on cell proliferation, survival and maturation following short-term (8-day) and long-term (24-day) exposure. Using 5'-bromo-2-deoxyuridine (BrdU) and Ki-67 as mitotic markers at the end of the drug treatments, we found that both short- and long-term cocaine exposures significantly reduced cell proliferation in the dentate gyrus (DG) of the hippocampus. By labelling mitotic cells with BrdU pulses before or during the early stages of the drug treatment, we determined that long-term cocaine…
Springback evaluation in fully 3-D sheet metal forming processes
1997
Abstract In the modern manufacturing industries the knowledge and proper control of the sheet metal springback after forming is a fundamental aspect in the achievement of near net shape stamped parts. In this paper an effective springback prediction in some fully three-dimensional stamping processes is carried out. Such a prediction is based on a combined approach in which an explicit finite element code has been employed to simulate the forming phase while a traditional implicit procedure has been used to analyse the springback phase. The results obtained have been compared with a set of experimental tests and an excellent correlation between the predicted and experimental data has been fo…
Scalable and Privacy-Preserving Admission Control for Smart Grids
2015
International audience; Energy demand and production need to be constantly matched in the power grid. The traditional paradigm to continuously adapt the production to the demand is challenged by the increasing penetration of more variable and less predictable energy sources, like solar photovoltaics and wind power. An alternative approach is the so called direct control of some inherently flexible electric loads to shape the demand. Direct control of deferrable loads presents analogies with flow admission control in telecommunication networks: a request for network resources (bandwidth or energy) can be delayed on the basis of the current network status in order to guarantee some performanc…
3D image acquisition system based on shape from focus technique
2013
agent Agrosup Dijon de l'UMREcolDurGEAPSI; This paper describes the design of a 3D image acquisition system dedicated to natural complex scenes composed of randomly distributed objects with spatial discontinuities. In agronomic sciences, the 3D acquisition of natural scene is difficult due to the complex nature of the scenes. Our system is based on the Shape from Focus technique initially used in the microscopic domain. We propose to adapt this technique to the macroscopic domain and we detail the system as well as the image processing used to perform such technique. The Shape from Focus technique is a monocular and passive 3D acquisition method that resolves the occlusion problem affecting…
New theoretical solution of the outflow process with a weir with complex shape
2016
AbstractIn this paper, the outflow process of a weir with an irregular shape is studied using dimensional analysis and the incomplete self-similarity theory. The new unique stage–discharge relationship, which is deduced theoretically, represents a novel and comprehensive equation to describe the weir outflow process for a full range of flow and different geometric variables of weirs, including finite-crested weirs, broad-crested weirs with positive or negative crest slope, broad-crested weirs with an upstream, downstream, or both upstream and downstream crest ramps, and, triangular weirs with an upstream or downstream ramp. Finally the proposed stage–discharge relationship is calibrated usi…
Free-surface shape in unbaffled stirred vessels: Experimental study via digital image analysis
2013
There is a growing interest in using unbaffled stirred tanks for addressing a number of processing needs such as low shear damage (sensitive biocultures), low attrition (solid–liquid applications), deep-cleaning/sterilization (pharmaceutical applications). The main feature of uncovered, unbaffled stirred tanks is highly swirling motion of the fluid that results in a deformation of the free liquid surface. At sufficiently high agitation speeds the resulting whirlpool reaches the impeller and gives rise to a gas–liquid dispersion, so leading to the formation of a dispersion without the use of gas-sparger; the so-called self-inducing operation of the vessel. In this work, digital image analysi…
U.I.R.D.A. – Unbuilt Italian Rationalism Digital Archive
2018
For twenty years, the architecture of Italian rationalism through the digital modelling has been investigated. Very often, the production of a model and the consequent representation of tridimensional views, in many case studies, as outcome of the research on architecture have been considered. Actually, the digital model, intended as a critical tool, has to be conceived as a ‘starting point' for graphic analysis of architecture and not as the outcome. Indeed, it is associated to other graphics, sometimes not ‘deducted' from the model, useful for the understanding/translation of architecture. The construction of the model is not the construction of a simple image, operation, which is often c…
Optimization of the contact surface shape of a shrinkage fit
1998
Amongst many processes existing today for the assembly of two cylindrical parts, the shrinkage fit is commonly used. However, in the calculation methods, the contact surfaces are assumed to be perfect. Therefore, in order to apply these, the standards necessitate very small geometrical tolerances. The objective of the present paper is to show that it is possible to take into account form defects by closely conformed contact modelling and to have a good representation of reality: form defects always exist to an increasing extent and are inherent in all kinds of manufacturing processes. Finally, it is shown that the presence of defects can be beneficial, allowing optimization from both a mech…