Search results for " simple"

Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.

1980

Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized.

Influence of dibutyryl cyclic AMP on thymidine uptake by herpes simplex virus infected cells and the intracellular level of cyclic AMP.

1977

Abstract Dibutyryl cyclic AMP inhibits the increase of dThd and BrdUrd transport normally observed after infection with Herpesvirus hominis, type I and II. Incorporation is also reduced. Inhibition of uptake is non-competitive as analysed by the Lineweaver-Burk plot. Addition of this drug to infected cells also reduces the activity of the thymidine kinase (EC 2.7.1.75). Transport of dUrd, dCyd and dAdo is not reduced. 4–8 h after infection with thymidine kinase (+) herpes strains the level of cAMP increases. On infection with a thymidine kinase (−) virus, only a small elevation of cAMP can be shown. It was also found that early addition of actinomycin D or of cycloheximide prevents the incr…

Suppression of humoral immune response against herpes simplex virus induced by defective strains, ts- and TK- mutants.

1988

Suppression of humoral antibody formation against HSV is not only induced by replicating Herpes simplex virus type 2 (HSV-2) but also by the defective strain ANG and the deletion mutant 1301 of Herpes simplex virus type 1 (HSV-1). Moreover, ts-mutants A, H, K, S, 1201 and 1208 of HSV-1 as well as some ts-mutants of HSV-2 and “defective-interfering” particles of HSV-1 after high multiplicity of infection-passages induced suppression. Treatment of infected mice with ACG reduced antibody-formation but did not result in suppression. UV-irradiation of the antibody producing strain Len of HSV-1 strongly reduces antibody formation and induces suppression. Experiments using a series of intertypic r…

Some results concerning simple locally finite groups of 1-type

2005

AbstractIn this paper several aspects of infinite simple locally finite groups of 1-type are considered. In the first part, the classes of diagonal limits of finite alternating groups, of diagonal limits of finite direct products of alternating groups, and of absolutely simple groups of 1-type are distinguished from each other. In the second part, inductive systems of representations over fields of characteristic zero (which are known to correspond to ideals in the group algebra) are studied in general for groups of 1-type. The roles of primitive respectively imprimitive representations in inductive systems are investigated. Moreover it is shown that in any proper inductive system the depth…

A Uniform Way to Control Chief Series in Finite p -Groups and to Construct the Countable Algebraically Closed Locally Finite p -Groups

1986

Unraveling the Complexity of Tourist Experience with NFC Technology and Mobile Wallets

2014

By considering the tourist experience as a complex dynamic system, in this paper we depict the traveler as a kybernetes (κυβeρνήτης is the ancient Greek word for ‘sea captain’, ‘steersman’, or ‘governor’) in search of powerful tools to help him or her to obtain directions in the mare magnum of complexity, overcoming the fear of action and taking decisions. We focus our attention on the key role of Near Field Communication technology and mobile wallet as ‘attenuators of complexity’ in the travel and tourism industry.

Analysis of the TK enzyme complex induced by HSV types 1 and 2 by means of isoelectric focusing and polyacrylamide gel electrophoresis.

1982

Recently we have described that the Herpes simplex virus (HSV)-induced thymidine kinase (TK) induces AMP- and ADP-dThd-5'-phosphotransferase activities. We now demonstrate the heterogeneity of the described activities in isoelectric focusing experiments and polyacrylamide gel electrophoresis. A TK--mutant of HSV type 1 fails to induce these activities. The activities of the type 1 enzyme complex was neutralized by an anti-HSV-serum. The TK-enzyme complex expressed in LTK--cells transformed to a TK+-phenotype by sheared HSV-1 DNA was compared with the wild type TK complex in isoelectric focusing experiments. Additionally we demonstrate that the HSV type 1 enzyme complex has thymidylate kinas…

Suppression of humoral antibody formation against sheep red blood cells by infections with HSV-2 and the influence of mouse cytomegalovirus

1987

HSV-2 infections suppress the antibody response to HSV-1 but do not impair the mouse cytomegalo virus (MCMV) antibody generating system. In contrast, the sheep red blood cell (SRBC) IgM response is impaired by preinfections with HSV-2 but not with HSV-1. From the time kinetics of this suppression it can be concluded that only a certain submechanism "spills over" to the SRBC system. MCMV suppresses the antibody formation induced by HSV-1.

Replication of HSV-1 in murine peritoneal macrophages: comparison of various virus strains with different properties.

1984

The in vitro replication of eleven different strains of herpes simplex virus type 1 was studied in resident or thioglycollate-stimulated mouse macrophages. The strains of herpes simplex virus differed in the type of cytopathic effect, induction capacity for herpes simplex virus coded thymidine kinase and pathogenicity in the mouse. Herpes simplex virus replicated better in thioglycollate-stimulated macrophages than in resident macrophages. In vitro ageing of macrophages increased their replicative potency. Herpes simplex virus replicated better in macrophages from homozygous bg/bg C57/BL6J mice than in macrophages from their heterozygous littermates. Separation of macrophages on discontinuo…

DESIGN OPTIMIZATION AND ANALYSIS OF A NEW REAR UNDERRUN PROTECTIVE DEVICE FOR TRUCK

2010

In this paper the optimization process of a new High Energy Absorption Rear Underrun Protective Device called HEARUPD is discussed. The main objectives of the HEARUPD design optimization process have been related to the reduction in car decelerations (high crashworthiness) and avoiding the car underrun (high structure stability). In the implemented optimization process, the crash between an economy car (GEO Metro) and the rear part of a truck has been simulated by numerical models. A linear function of the decelerations measured on the car has been used as objective to minimize, the main dimensional values of the rear underrun protective device, instead, have been chosen as design variables…