Search results for " stratification"
showing 10 items of 144 documents
High-sensitivity troponin I for risk stratification in normotensive pulmonary embolism
2020
While numerous studies have confirmed the prognostic role of high-sensitivity troponin T (hsTnT) in pulmonary embolism (PE), high-sensitivity troponin I (hsTnI) is inappropriately studied. This study aimed to investigate the prognostic relevance of hsTnI in normotensive PE, establish the optimal cut-off value for risk stratification and to compare the prognostic performances of hsTnI and hsTnT. Based on data from 459 consecutive PE patients enrolled in a single-centre registry, receiver operating characteristic analysis was used to identify an optimal hsTnI cut-off value for prediction of in-hospital adverse outcomes (PE-related death, cardiopulmonary resuscitation or vasopressor treatment)…
Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study.
2018
To externally validate the prognostic impact of copeptin, either alone or integrated in risk stratification models, in pulmonary embolism (PE), we performed a post hoc analysis of 843 normotensive PE patients prospectively included in three European cohorts.Within the first 30 days, 21 patients (2.5%, 95% CI 1.5–3.8) had an adverse outcome and 12 (1.4%, 95% CI 0.7–2.5) died due to PE. Patients with copeptin ≥24 pmol·L−1 had a 6.3-fold increased risk for an adverse outcome (95% CI 2.6–15.5, p<0.001) and a 7.6-fold increased risk for PE-related death (95% CI 2.3–25.6, p=0.001). Risk classification according to the 2014 European Society of Cardiology (ESC) guideline algorithm identified 248…
Prognostic Value of Troponins in Patients With or Without Coronary Heart Disease: Is it Dependent on Structure and Biology?
2020
Convincing evidence has emerged that cardiac troponins (cTns) T and I are the biochemical gold standard for diagnosing cardiac injury, and may also be used as efficient screening and risk stratification tools, especially when measured with the new high-sensitivity (hs-) immunoassays. In this narrative review, we aim to explore and critically discuss the results of recent epidemiological studies that have attempted to characterise the prognostic value of cTns in patients with or without cardiovascular disease, and then interpret this information according to cTn biology. Overall, all recent studies agree that higher blood levels of cTns reflect the larger risk of cardiovascular events and/or…
Patterns of oncogene co-expression at single cell resolution in cancer influence survival
2020
AbstractBackgroundCancers often overexpress multiple clinically relevant oncogenes. However, it is not known if multiple oncogenes within a cancer combine uniquely in specific cellular sub-populations to influence clinical outcome. We studied this phenomenon using the prognostically relevant oncogenes MYC, BCL2 and BCL6 in Diffuse Large B-Cell Lymphoma (DLBCL).MethodsQuantitative multispectral imaging simultaneously measured oncogene co-expression at single-cell resolution in reactive lymphoid tissue (n=12) and four independent cohorts (n=409) of DLBCL. Mathematically derived co-expression phenotypes were evaluated in DLBCLs with immunohistochemistry (n=316) and eight DLBCL cohorts with gen…
From limit to centrality. Regeneration of the Genoa's port area through architectural and urban design
2012
This survey’s core is the case study of the regeneration of the port area and of the urban waterfront of the city of Genoa, as an emblematic example where the architectural and urban design plays an important role, oriented to the transformation of the port area and to the modification of the relationship that exists between the harbour and the city. In particular this will deepen the possibility, to reverse the condition of limit that characterizes the port area into a new centrality, through the design, passing by intermediate steps that redefine the modalities of access and of connection between city and port, breaking the condition of isolation that ports usually present. As a matter of…
Controversial issues in soft tissue solitary fibrous tumors: A pathological and molecular review
2019
The clinical evolution of solitary fibrous tumor (SFT) remains unclear. Although various clinical, morphological and molecular criteria may indicate increased risk of malignancy, some SFT can still progress despite having a clearly benign appearance. Various risk stratification systems have been proposed, but unfortunately they are not sufficient to precisely determine the malignant potential. In this review, we discuss current knowledge on SFT, focusing on the following controversial issues: (i) the diverse morphologic spectrum: 'the great simulator;' (ii) malignant transformation or dedifferentiation; (iii) current risk stratification systems; and (iv) molecular factors associated with cl…
Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations
2016
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp.) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This pa…
Wine and Its Legality-A Survey to Know the Consumer Opinions on the Activities of Sicilian Wine Companies Operating on Lands Confiscated from the Maf…
2014
The current guidelines of the European Union Common Agricultural Policy face the agricultural sector in the position of the backbone for the economic development of rural areas and regions with difficult economic differentiation. The EU Common Agricultural Policy defines agriculture as “multifunctional” and among the different roles and functions expected, there is also the “social function”, defined as the ability that the farm has to generate services with respect to a population with risk of social exclusion. This paper investigated all the agricultural initiatives with social impacts that were carried in the lands confiscated from the organized crime (called mafia), mainly in the South …
Laghi Artificiali dell'Italia meridionale e delle isole maggiori
2014
In questo articolo gli autori analizzano i principali fattori ecologici che determinano il funzionamento dei laghi artificiali localizzati nel meridione d’Italia e nelle isole maggiori. In particolare, viene illustrato come il ciclo idrologico annuale di questi ecosistemi sia fortemente influenzato dalle attività umane connesse all’uso dell’acqua invasata. Tali attività spesso interferiscono negativamente con la dinamica dei fattori fisici (stratificazione/circolazione), chimici (concentrazioni di nutrienti e ossigeno) e biologici (successione stagionale del fitoplancton) che governano il funzionamento di questi ecosistemi. Comprendere come il cambiamento climatico in atto influenzi il cicl…
Heterogeneous vertical structure of the bacterioplankton community in a non-stratified Antarctic lake
2013
10 páginas, 4 figuras, 2 tablas.