Search results for " stream"
showing 10 items of 205 documents
Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell–cell Adhesion in the Postnatal Brain
2018
In the rodent olfactory system, neuroblasts produced in the ventricular-subventricular zone of the postnatal brain migrate tangentially in chain-like cell aggregates toward the olfactory bulb (OB) through the rostral migratory stream (RMS). After reaching the OB, the chains are dissociated and the neuroblasts migrate individually and radially toward their final destination. The cellular and molecular mechanisms controlling cell–cell adhesion during this detachment remain unclear. Here we report that Fyn, a nonreceptor tyrosine kinase, regulates the detachment of neuroblasts from chains in the male and female mouse OB. By performing chemical screening andin vivoloss-of-function and gain-of-f…
Ultrastructure of the subventricular zone in Macaca fascicularis and evidence of a mouse-like migratory stream.
2009
Recent publications have shown that the lateral wall of the lateral ventricles in the Macaca fascicularis brain, in particular the subventricular zone (SVZ), contains neural stem cells throughout adulthood that migrate through a migratory pathway (RMS) to the olfactory bulb (OB). To date, a detailed and systematic cytoarchitectural and ultrastructural study of the monkey SVZ and RMS has not been done. We found that the organization of the SVZ was similar to that of humans, with the ependymal layer surrounding the lateral ventricles, a hypocellular GAP layer formed by astrocytic and ependymal expansions, and the astrocyte ribbon, composed of astrocytic bodies. We found no cells corresponding…
Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain.
1997
The adult mammalian subventricular zone (SVZ) contains stem cells that give rise to neurons and glia.In vivo, SVZ progeny migrate 3–8 mm to the olfactory bulb, where they form neurons. We show here that the SVZ of the lateral wall of the lateral ventricles in adult mice is composed of neuroblasts, glial cells, and a novel putative precursor cell. The topographical organization of these cells suggests how neurogenesis and migration are integrated in this region. Type A cells had the ultrastructure of migrating neuronal precursors. These cells were arranged as chains parallel to the walls of the ventricle and were polysialylated neural adhesion cell molecule- (PSA–NCAM), TuJ1- (β-tubulin), an…
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
1999
AbstractNeural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This germinal region, which continually generates new neurons destined for the olfactory bulb, is composed of four cell types: migrating neuroblasts, immature precursors, astrocytes, and ependymal cells. Here we show that SVZ astrocytes, and not ependymal cells, remain labeled with proliferation markers after long survivals in adult mice. After elimination of immature precursors and neuroblasts by an antimitotic treatment, SVZ astrocytes divide to generate immature precursors and neuroblasts. Furthermore, in untreated mice, SVZ astrocytes specifically infected with a retrovirus give rise to new n…
Migration of Neuronal Precursors From the Telencephalic Ventricular Zone Into the Olfactory Bulb in Adult Zebrafish
2011
In the brain of adult mammals, neuronal precursors are generated in the subventricular zone in the lateral wall of the lateral ventricles and migrate into the olfactory bulbs (OBs) through a well-studied route called the rostral migratory stream (RMS). Recent studies have revealed that a comparable neural stem cell niche is widely conserved at the ventricular wall of adult vertebrates. However, little is known about the migration route of neuronal precursors in nonmammalian adult brains. Here, we show that, in the adult zebrafish, a cluster of neuronal precursors generated in the telencephalic ventricular zone migrates into the OB via a route equivalent to the mammalian RMS. Unlike the mamm…
Across space and time : infants learn from backward and forward visual statistics
2016
International audience; This study investigates whether infants are sensitive to backward and forward transitional probabilities within temporal and spatial visual streams. Two groups of 8-month-old infants were familiarized with an artificial grammar of shapes, comprising backward and forward base pairs (i.e. two shapes linked by strong backward or forward transitional probability) and part-pairs (i.e. two shapes with weak transitional probabilities in both directions). One group viewed the continuous visual stream as a temporal sequence, while the other group viewed the same stream as a spatial array. Following familiarization, infants looked longer at test trials containing part-pairs th…
Bibliometric analysis of absorptive capacity
2017
Abstract This study contributes to our understanding of absorptive capacity (AC) by reviewing AC articles systematically using two types of blibliometric co-citation analysis – bibliometric co-citation and bibliometric cartography – for the last 25 years. In total, we analyzed 336 articles (using HistCite ) and 2088 articles (using VOSviewer ), respectively, finding five research streams in AC: (1) intra-organizational learning; (2) inter-organizational learning; (3) knowledge transfer; (4) dynamic capability; and (5) micro-foundations. This integrative literature review of AC adds to the categorization of the literature, links the international business research to AC, and provides promisi…
Business models of FinTechs – Difference in similarity?
2021
Abstract The FinTech industry is gradually maturing and offers a wide range of financial services on the global stage. Still, the understanding of FinTech business models remains at its infancy with a shortage of cross-country comparisons. This paper aims to determine the differences in business model attributes of FinTechs in five rapidly emerging FinTech hotspots in Central and Eastern Europe (CEE). Survey results from Estonia, Latvia, Lithuania, Poland, and Russia, accompanied by cluster analysis, enable us to provide unique in-depth evidence on FinTech business models. Across the selected countries, we observe significant differences in the attributes of FinTech business models: key act…
Interorganizational network and innovation: a bibliometric study and proposed research agenda
2015
Purpose – This paper aims to explore the latent structure of the literature on interorganizational network and innovation as well as to map the main themes and empirical advances in this research stream. Design/methodology/approach – Using bibliometric coupling, the authors analyze the citation patterns in 67 management studies regarding innovation networks, published in ISI-journals from January 1996 to October 2012. Findings – The authors identify the conceptual orientations that studies share. Bibliometric analysis allows us to draw an overview of how this field of research has developed, recognizing in essence six main clustered research themes: networks as a framework that sustains fi…
Engineering a Digital Twin for Manual Assembling
2021
The paper synthesizes our preliminary work on developing a digital twin, with learning capabilities, for a system that includes cyber, physical, and social components. The system is an industrial workstation for manual assembly tasks that uses several machine learning models implemented as microservices in a hybrid architecture, a combination between the orchestrated and the event stream approaches. These models have either similar objectives but context-dependent performance, or matching functionalities when the results are fused to support real-life decisions. Some of the models are descriptive but easy to transform in inductive models with extra tuning effort, while others are purely ind…