Search results for " surface"
showing 10 items of 2838 documents
Integrated optic surface plasmon resonance measurements in a borosilicate glass substrate
2008
The surface plasmon resonance (SPR) technique is a well-known optical method that can be used to measure the refractive index of organic nano-layers adsorbed on a thin metal film. Although there are many configurations for measuring biomolecular interactions, SPR-based techniques play a central role in many current biosensing experiments, since they are the most suited for sensitive and quantitative kinetic measurements. Here we give some results from the analysis and numerical elaboration of SPR data from integrated optics experiments in a particular borosilicate glass, chosen for its composition offering the rather low refractive index of 1.4701 at 633 nm wavelength. These data regard the…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysin…
2016
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foral was also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on pe…
Entry of Human Parechovirus 1
2001
ABSTRACT Human parechovirus 1 (HPEV-1) is a prototype member of parechoviruses, a recently established picornavirus genus. Although there is preliminary evidence that HPEV-1 recognizes α V integrins as cellular receptors, our understanding of early events during HPEV-1 infection is still very limited. The aim of this study was to clarify the entry mechanisms of HPEV-1, including the attachment of the virus onto the host cell surface and subsequent internalization. In blocking experiments with monoclonal antibodies against different receptor candidates, antibodies against α V and β 3 integrin subunits, in particular in combination, appeared to be the most efficient ones in preventing the HPE…
A unified approach to quasi-static shakedown problems for elastic-plastic solids with piecewise linear yield surface
1978
The paper concerns shakedown analysis of elastic-plastic bodies subjected to quasi-statically varying loads within a given domain. Using a perturbation method, a general inequality is given, from which, by simply specializing the perturbing terms, the generalized Melan theorem as well as bounds on various deformation parameters (such as displacements or plastic strain intensities) are derived. The solution of the «perturbed» shakedown problem in finite or holonimic terms permits the bound to be the most stringent and expressible in «local» terms instead of integral terms. A simple application concludes the paper.
Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
2015
The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the oil to the skin.S. insularis essential oil was obtained by steam distillation, and was predominantly composed of terpenes, the most abundant being β-phellandrene (22.6%), myrcene (11.4%) and curcumenes (12.1%). Vesicles were prepared using phosphatidylcholine, and ethylene or propylene glycol were added to the water phase (10% (v/v)) to improve vesicle performances as delivery systems. Vesicles were deeply characterized by light scattering,…
Hidden Oscillations In The Closed-Loop Aircraft-Pilot System And Their Prevention* *This work was supported by Russian Science Foundation (project 14…
2016
Abstract The paper is devoted to studying and prevention of a special kind of oscillations-the Pilot Involved Oscillations (PIOs) which may appear in man-machine closed-loop dynamical systems. The PIO of categories II and III are defined as essentially non-linear unintended steady fluctuations of the piloted aircraft, generated due to pilot efforts to control the aircraft with a high precision. The main non-linear factor leading to the PIO is, generally, rate limitations of the aircraft control surfaces, resulting in a delay in the response of the aircraft to pilot commands. In many cases, these oscillations indicate presence of hidden, rather than self-excited attractors in the aircraft-pi…
A methodology for obtaining the crop temperature from NOAA-9 AVHRR data
1991
Abstract In this paper a methodology for obtaining the crop temperature from NOAA-9 AVHRR data has been developed, which is based on a theoretical model that permits interpreting the remote sensing temperature measurement in heterogeneous and rough surfaces. This procedure determines the crop temperature by evaluating prsviously: (1) the temperature difference between crop and ground, (2) the atmospheric and emissivity corrections, (3) the ground and vegetation emissi-vities in the AVHRR bands 4 (10-3-11-3 μm) and 5 (11 -5-12-5 μm), and (4) the proportion of ground in each pixel. We have applied this method to obtain a map of orange-tree temperatures for the Valencian region and satisfactor…
Enantioselective Total Syntheses of (+)-Hippolachnin A, (+)-Gracilioether A, (-)-Gracilioether E, and (-)-Gracilioether F.
2018
The Plakortin polyketides represent a structurally and biologically fascinating class of marine natural products. Herein, we report a unified strategy that enables the divergent syntheses of various Plakortin polyketides with high step-economy and overall efficiency. As proof-of-concept cases, the enantioselective total syntheses of (+)-hippolachnin A, (+)-gracilioether A, (-)-gracilioether E, and (-)-gracilioether F have been accomplished based on a series of bio-inspired, rationally designed, or serendipitously discovered transformations, which include (1) an organocatalytic asymmetric 1,4-conjugate addition to assemble the common chiral γ-butenolide intermediate enroute to all of the afo…
Robotic Exploration of Planetary Surfaces – Rover Technologies Developed for Space Exploration
2009
Mobility is a key feature for any science mission and for space exploration in general. Missions with mobile systems provide a much wider spectrum of outcomes by employing a higher number of samples within an increased area of exploration. The additional degree of freedom of a rover in comparison to a lander or even a robotic arm allows the mission to be flexibly adapted to the landing site as it is encountered.
Orbital variations in planktonic foraminifera assemblages from the Ionian Sea during the Middle Pleistocene Transition
2013
Abstract The Middle Pleistocene Transition (1.2–0.7 Ma) is the most recent re-organization of the global climate system which includes variations in the frequency and amplitude of glacial/interglacial cycles, increased ice sheet volume, sea surface temperature cooling and a significant drop in the CO 2 atmospheric levels. Here we present high-resolution planktonic foraminifera data (mean sampling resolution of about 780 years) from core LC10 recovered in the Ionian Sea (eastern Mediterranean), between 1.2 and 0.9 Ma. Selected taxa, among them G. ruber , T. quinqueloba and G. bulloides , show significant periodicities that can be associated to orbital cycles, mainly precession and obliquity.…