Search results for " switching"
showing 10 items of 176 documents
Inhibition of murine IgE and immediate cutaneous hypersensitivity responses to ovalbumin by the immunomodulatory agent leflunomide
1999
SUMMARYLeflunomide has been identified as an immunoregulatory and anti-inflammatory compound. Allergic disease is characterized by elevated serum IgE levels, production of allergen-specific IgE and the release of inflammatory mediators from mast cells and granulocytes. Here we demonstrate, using an in vivo murine model, the ability of leflunomide to down-regulate levels of total and allergen-specific serum IgE production. Mice receiving leflunomide (45 mg/kg) orally at the time of primary immunization with ovalbumin adsorbed to aluminium hydroxide adjuvant, showed a reduction in total serum IgE levels of 95%, 41% and 32% following primary, secondary and tertiary immunizations, respectively …
Toll-like receptors – sentries in the B-cell response
2009
Summary Toll-like receptors (TLR) play a central role in the initiation of the innate immune response to pathogens. Upon recognition of molecular motifs specific for microbial molecules TLR mediate pro-inflammatory cytokine secretion and enhance antigen presentation; in B cells they further promote expansion, class switch recombination and immunoglobulin secretion. As a result of their adjuvant properties, TLR ligands have become an integral component of antimicrobial vaccines. In spite of this, little is known of the direct effects of TLR engagement on B-lymphocyte function. The scope of this review is to outline the differences in TLR expression and reactivity in murine and human B-cell s…
Effect of platform switching on the peri-implant bone: A finite element study
2015
Background: There exists a relation between the presence and location of the micro-gap and the loss of peri-implant bone. Several authors have shown that the treatments based on the use of platform switching result in less peri-implant bone loss and an increased tissue stability. The purpose of this study was to analyse the effect of the platform switching on the distribution of stresses on the peri-implant bone using the finite element method. Material and Methods: A realistic 3D full-mandible finite element model representing cortical bone and trabecular bone was used to study the distribution of the stress on the bone induced by an implant of diameter 4.1 mm. Two abutments were modelled.…
Dissensus, death and division
2009
The modeling of switching systems describing networks where death and duplication processes occur is described. A dissensus protocol, complementary to consensus protocol, is introduced and the convergence or divergence of the agents' state evolution is studied. We discuss some properties of the topology reached by the network when different rules of duplication and inheritance are implemented.
Phenotypic Heterogeneity of the Insect Pathogen Photorhabdus luminescens: Insights into the Fate of Secondary Cells
2019
Photorhabdus luminescens is a Gram-negative bacterium that lives in symbiosis with soil nematodes and is simultaneously highly pathogenic toward insects. The bacteria exist in two phenotypically different forms, designated primary (1°) and secondary (2°) cells. Yet unknown environmental stimuli as well as global stress conditions induce phenotypic switching of up to 50% of 1° cells to 2° cells. An important difference between the two phenotypic forms is that 2° cells are unable to live in symbiosis with nematodes and are therefore believed to remain in the soil after a successful infection cycle. In this work, we performed a transcriptomic analysis to highlight and better understand the rol…
Survey data and Bayesian analysis: a cost-efficient way to estimate customer equity
2014
We present a Bayesian framework for estimating the customer lifetime value (CLV) and the customer equity (CE) based on the purchasing behavior deducible from the market surveys on customer purchasing behavior. The proposed framework systematically addresses the challenges faced when the future value of customers is estimated based on survey data. The scarcity of the survey data and the sampling variance are countered by utilizing the prior information and quantifying the uncertainty of the CE and CLV estimates by posterior distributions. Furthermore, information on the purchase behavior of the customers of competitors available in the survey data is integrated to the framework. The introduc…
INFLUENCE OF LENGTH ON THE NOISE DELAYED SWITCHING OF LONG JOSEPHSON JUNCTIONS
2008
The transient dynamics of long overlap Josephson junctions in the frame of the sine-Gordon model with a white noise source is investigated. The effect of noise delayed decay is observed for the case of overdamped sine-Gordon equation. It is shown that this noise induced effect, in the range of small noise intensities, vanishes for junctions lengths greater than several Josephson penetration length.
Stabilization Effects of Dichotomous Noise on the Lifetime of theSuperconducting State in a Long Josephson Junction
2015
We investigate the superconducting lifetime of a long overdamped current-biased Josephson junction, in the presence of telegraph noise sources. The analysis is performed by randomly choosing the initial condition for the noise source. However, in order to investigate how the initial value of the dichotomous noise affects the phase dynamics, we extend our analysis using two different fixed initial values for the source of random fluctuations. In our study, the phase dynamics of the Josephson junction is analyzed as a function of the noise signal intensity, for different values of the parameters of the system and external driving currents. We find that the mean lifetime of the superconductive…
DEVELOPMENT OF LIQUID CRYSTAL LAYER THICKNESS AND REFRACTIVE INDEX MEASUREMENT METHODS FOR SCATTERING TYPE LIQUID CRYSTAL DISPLAYS
2022
The research has been supported by ERDF No.1.1.1.1/19/A/120 “Improvement of Electro-Optical Characteristics of Liquid Crystal Shutters”.
Resistive switching behaviour in ZnO and VO 2 memristors grown by pulsed laser deposition
2014
The resistive switching behaviour observed in microscale memristors based on laser ablated ZnO and VO 2 is reported. A comparison between the two materials is reported against an active device size. The results show that devices up to 300 × 300 μm 2 exhibit a memristive behaviour regardless of the device size, and 100 × 100 μm 2 ZnO-based memristors have the best resistance off/on ratio.