Search results for "ètica"
showing 10 items of 343 documents
Genome-wide studies of mRNA synthesis and degradation in eukaryotes
2012
In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing results for thousands of genes at every step of mRNA life. The statistical analyses of the results for a single condition, different conditions, different transcription stages, or even between different techniques, is outlining a totally new landscape of the eukaryotic transcription process. Although most studies have been conducted in the yeast Saccharomyces cerevisiae as a model cell, others have also focused on higher eukaryotes, which can also be comparatively analyzed. The picture which emerges is that transcription is a more variable process than initially suspected,…
Genomics of mRNA turnover
2007
Most studies on eukaryotic gene regulation have focused on mature mRNA levels. Nevertheless, the steady-state mRNA level is the result of two opposing biological processes: transcription and degradation, both of which can be important points to regulate gene expression. It is now possible to determine the transcription and degradation rates (TR and DR), as well as the mRNA amount, for each gene using DNA chip technologies. In this way, each individual contribution to gene expression can be analysed. This review will deal with the techniques used for the genomic evaluation of TR and DR developed for the yeast Saccharomyces cerevisiae. They will be described in detail and their potential draw…
A method for genome-wide analysis of DNA helical tension by means of psoralen-DNA photobinding
2010
The helical tension of chromosomal DNA is one of the epigenetic landmarks most difficult to examine experimentally. The occurrence of DNA crosslinks mediated by psoralen photobinding (PB) stands as the only suitable probe for assessing this problem. PB is affected by chromatin structure when is done to saturation; but it is mainly determined by DNA helical tension when it is done to very low hit conditions. Hence, we developed a method for genome-wide analysis of DNA helical tension based on PB. We adjusted in vitro PB conditions that discern DNA helical tension and applied them to Saccharomyces cerevisiae cells. We selected the in vivo cross-linked DNA sequences and identified them on DNA …
A genomic view of mRNA turnover in yeast
2011
The steady-state mRNA level is the result of two opposing processes: transcription and degradation; both of which can provide important points to regulate gene expression. In the model organism yeast Saccharomyces cerevisiae, it is now possible to determine, at the genomic level, the transcription and degradation rates, as well as the mRNA amount, using DNA chip or parallel sequencing technologies. In this way, the contribution of both rates to individual and global gene expressions can be analysed. Here we review the techniques used for the genomic evaluation of the transcription and degradation rates developed for this yeast, and we discuss the integration of the data obtained to fully an…
Jürgen Habermas and the risk of liberal eugnics for the ethical self-understanding of species
2016
The article analyzes the problem of human nature that presents Jürgen Habermas in his work The future of human nature, Towards a liberal eugenics? The rapid advances in biotechnology demand a rigorous bioethical reflection that the German philosopher confronts superimposing to his ethics of the discourse a new ethics of the species. Habermas outlines a model of human nature built on precepts such as human dignity and dignity of the human life, symmetry of people's inter-relationships and, as a result of these, the ethical self-understanding of the species. Regarding the liberal eugenics, the author criticizes positive eugenics and protects the negative one, for which bases its argument abou…
The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging stu…
2017
Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N = 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared …
Tipología de los errores en el cálculo mental : un estudio en el contexto educativo
1995
Resumen basado en el de la publicación Resumen en inglés Se aborda una tipología de errores y dificultades de los estudiantes españoles de un Colegio de Formación de Profesores cuando aplican métodos históricos de cálculo mental (métodos tomados de la tradición escrita que se encuentra en la aritmética) de los libros de texto para resolver problemas con números naturales y con números decimales. ESP
Processos i mecanismes evolutius: Pràctiques d'informàtica
2016
S'inclouen dues pràctiques informàtiques amb el software docent de lliure distribució Populus. Les pràctiques tenen com a objectiu familiaritzar l'estudiant amb els processos de selecció natural i deriva genètica aleatòria mitjançant simulacions computacionals. L'estudiant haurà de resoldre qüestions pràctiques.
Processos i Mecanismes Evolutius: Problemes
2016
S´inclouen dues enunciats de problemes de genètica de poblacions, que permetran l´estudiant aprofundir en els conceptes de equilibri de Hardy-Weinberg, selecció natural, deriva genètica aleatòria, mutació, migració i endogàmia.
Tècniques d'anàlisi genètica: Tema 3
2014
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. Tema 3 de, de què consta l'assignatura. Tracta de la complementació gènica i de la localització cromosòmica precisa de gens mitjançant l'ús de delecions en Drosophila melanogaster