Search results for "0.9"
showing 10 items of 2547 documents
Minimal clinically important difference and minimal detectable change of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0…
2020
Objectives: The aim of this study is to estimate a minimal clinically important difference (MCID) and a minimal detectable change (MDC) of the 12-item WHODAS 2.0 amongst patients with chronic musculoskeletal pain. Design: Cross-sectional cohort study. Setting: Outpatient Physical and Rehabilitation Medicine clinic. Subjects: A total of 1988 consecutive patients with musculoskeletal pain. Interventions: A distribution-based approach was employed to estimate a minimal clinically important difference, a minimal detectable change, and a minimal detectable percent change (MDC%). Results: The mean age of the patients was 48 years, and 65% were women. The average intensity of pain was 6,3 (2.0) po…
SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients
2020
Background The involvement of SARS-CoV-2 antibodies in mediating immunopathogenetic events in COVID-19 patients has been suggested. By using several experimental approaches, we investigated the potential association between SARS-CoV-2 IgGs recognizing the spike (S) protein receptor-binding domain (RBD), neutralizing antibodies (NtAb) targeting S, and COVID-19 severity. Patients and methods This unicenter, retrospective, observational study included 51 hospitalized patients (24 at the intensive care unit; ICU). A total of 93 sera from these patients collected at different time points from the onset of symptoms were analyzed. SARS-CoV-2 RBD IgGs were quantitated by ELISA and NtAb50 titers wer…
Editorial: The Challenge of New Therapeutic Approaches for Unmet Therapeutic Needs
2020
Bioactive pyrrole-based compounds with target selectivity
2020
The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in medicinal chemistry. Natural products have inspired the synthesis of compounds for pharmaceutical application, most of which are based on N-heterocyclic motifs. Among these, the pyrrole ring is one of the most explored heterocycles in drug discovery programs for several therapeutic areas, confirmed by the high number of pyrrole-based drugs reaching the market. In the present review, we focused on pyrrole and its hetero-fused derivatives with anticancer, antimicrobial, and antiviral activities, reported in the literature between 2015 and 2019, for which a specific target was identified, being resp…
Les ultimes feux de la résistance païenne dans l'antiquité tardive
2010
Os trabalhos recentes do autor convidam a um exame renovado do significado ideológico e religioso de certas fontes historiográficas importantes do final do século IV, entre as quais a História Augusta. De fato, parece que esta obra se inscreve, com outras, no contexto do último combate conduzido contra o cristianismo triunfante pelos derradeiros defensores da antiga religião da qual Nicômaco Flaviano sênior surge como o principal líder. De 384, data da morte de Pretextato, a 395. data da morte de Teodósio, os pagão puderam preservar os cultos antigos, chegando inclusive a armar-se em boa medida por este motivo, na batalha de Frígido. Entre 395 e 408, isto é, até o desaparecimento de Estili…
Endometrial Receptivity Analysis (ERA): data versus opinions
2021
Abstract This article summarises and contextualises the accumulated basic and clinical data on the ERA test and addresses specific comments and opinions presented by the opponent as part of an invited debate. Progress in medicine depends on new technologies and concepts that translate to practice to solve long-standing problems. In a key example, combining RNA sequencing data (transcriptomics) with artificial intelligence (AI) led to a clinical revolution in personalising disease diagnosis and fostered the concept of precision medicine. The reproductive field is no exception. Translation of endometrial transcriptomics to the clinic yielded an objective definition of the limited time period …
A Taxonomy as a Vehicle for Learning
2009
In this article, we describe the development of a classification system providing a framework for analysis of, and communication about, a subgroup of learning objects. The objects we consider are highly visual, animated, interactive, and mathematics-related, and we call them VaniMaps. Secondly, we discuss the use of the system. In the first phase, the development was based on literature studies and discussions on examples of VaniMaps. In the second phase, the classification system was tested by students and their responses were analyzed to identify possible improvements. Now, the system is developed further based on experience gained while using it for different purposes. We see several pos…
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systema…
2020
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Gianfrancesco Maineri, Paolo da San Leocadio i la gènesi d?un model de Crist portacreu
2020
[CA] El present article es centra en la vinculació entre els diversos exemplars de Crist portacreu de Gianfrancesco Maineri i els homònims de Paolo da San Leocadio. A través de diverses comparacions, tractarà d¿explicar-se la gènesi d¿aquest model, aportant, a més, dades que permetran una millor classificació dels exemplars leocadians. Finalment, es realitzen una sèrie de reflexions entorn de l¿hipotètic retorn de San Leocadio a Itàlia (1485-1489) i a la seua possible vinculació amb Maineri.
Formación artística en el grado de maestro de primaria de la Universitat de València. Enfoques y propuestas
2014
Este trabajo presenta una propuesta enfocada a mejorar la docencia en el actual grado de maestro de Primaria en lo que a Educación Artística se refiere, según el plan de estudios de la Facultat de Magisteri de la Universitat de València. La implantación del grado es relativamente reciente con lo cual permite plantearse mejoras que conlleven dotar a los futuros maestros de herramientas que optimicen sus conocimientos del área artística. Así, se llevará a cabo una colaboración horizontal basada en la cooperación entre profesores de las diferentes áreas artísticas: Educación Plástica y Música. Por ello, se plantea la puesta en práctica de una metodología innovadora de índole cooperativa, revis…