Search results for "030204 cardiovascular system & hematology"

showing 10 items of 3288 documents

The effect of bergamot on dyslipidemia

2016

Abstract Background Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evid…

3003CitrusFuture studiesBergamotPharmaceutical Science030204 cardiovascular system & hematologyBioinformatics01 natural sciences03 medical and health scienceschemistry.chemical_compound0302 clinical medicineNutraceuticalDrug DiscoverymedicineAnimalsHumansAdverse effectDyslipidemiasHypolipidemic AgentsFlavonoidsPharmacologyPlant ExtractsChemistryCholesterolMedicine (all)Drug Discovery3003 Pharmaceutical ScienceCardiovascular riskComplementary and Alternative Medicine2708 Dermatologymedicine.disease0104 chemical sciences010404 medicinal & biomolecular chemistryDyslipidemiaComplementary and alternative medicineBiochemistryLDL cholesterolCitrus bergamiaMolecular MedicineNarrative reviewLipid loweringDyslipidemiaPhytomedicine
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Quality Control in 3D Printing: Accuracy Analysis of 3D-Printed Models of Patient-Specific Anatomy

2021

As comparative data on the precision of 3D-printed anatomical models are sparse, the aim of this study was to evaluate the accuracy of 3D-printed models of vascular anatomy generated by two commonly used printing technologies. Thirty-five 3D models of large (aortic, wall thickness of 2 mm, n = 30) and small (coronary, wall thickness of 1.25 mm, n = 5) vessels printed with fused deposition modeling (FDM) (rigid, n = 20) and PolyJet (flexible, n = 15) technology were subjected to high-resolution CT scans. From the resulting DICOM (Digital Imaging and Communications in Medicine) dataset, an STL file was generated and wall thickness as well as surface congruency were compared with the original …

3d printedMaterials science3D printing3d modelFDM printing030204 cardiovascular system & hematologylcsh:TechnologyArticle030218 nuclear medicine & medical imaginglaw.invention03 medical and health sciencesDICOM3D engineering0302 clinical medicinelawStl fileGeneral Materials Sciencelcsh:Microscopycoronarylcsh:QC120-168.85anatomical modellcsh:QH201-278.5Fused deposition modelingaccuracyPolyJet printinglcsh:Tbusiness.industryAnatomy3D printingPatient specificaortalcsh:TA1-2040lcsh:Descriptive and experimental mechanicslcsh:Electrical engineering. Electronics. Nuclear engineeringlcsh:Engineering (General). Civil engineering (General)Wall thicknessbusinesslcsh:TK1-9971Materials
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Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

2020

Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA an…

:Chemicals and Drugs::Pharmaceutical Preparations::Placebos [Medical Subject Headings]Physiologyα -lipoic acid ; thioctic acid ; dietary supplement ; safety ; meta-analysisClinical BiochemistryDisease030204 cardiovascular system & hematologyBiochemistrymeta-analysi:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings]Dietary supplementchemistry.chemical_compound0302 clinical medicinethioctic aciddietary supplement meta-analysis safety thioctic acid α-lipoic acid:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]α-lipoic acidLipoic acidSafety profile:Publication Type::Study Characteristics::Meta-Analysis [Medical Subject Headings]Suplementos dietéticosMeta-analysis:Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings]SafetysafetyAlpha-lipoic acidmedicine.medical_specialtyMEDLINEÁcido tióctico030209 endocrinology & metabolismPlacebo:Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiophenes::Thioctic Acid [Medical Subject Headings]Article:Health Care::Environment and Public Health::Public Health::Accidents::Accident Prevention::Safety [Medical Subject Headings]03 medical and health sciencesα‐lipoic acidThioctic acidInternal medicineDiabetes mellitusmedicineMetaanálisisAdverse effectSeguridad:Diseases::Cardiovascular Diseases [Medical Subject Headings]Molecular Biology:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Volatile [Medical Subject Headings]business.industryRevisión sistemáticalcsh:RM1-950Cell Biologymedicine.disease:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Food Habits::Smoking [Medical Subject Headings]meta-analysisMeta-analysislcsh:Therapeutics. Pharmacologychemistry:Diseases::Nervous System Diseases [Medical Subject Headings]dietary supplementMeta‐analysisbusinessAntioxidants
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Cardiovascular and Renal Outcomes of Renin–Angiotensin System Blockade in Adult Patients with Diabetes Mellitus: A Systematic Review with Network Met…

2016

Background Medications aimed at inhibiting the renin–angiotensin system (RAS) have been used extensively for preventing cardiovascular and renal complications in patients with diabetes, but data that compare their clinical effectiveness are limited. We aimed to compare the effects of classes of RAS blockers on cardiovascular and renal outcomes in adults with diabetes. Methods and Findings Eligible trials were identified by electronic searches in PubMed/MEDLINE and the Cochrane Database of Systematic Reviews (1 January 2004 to 17 July 2014). Interventions of interest were angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and direct renin (DR) inhibitors. T…

ACE inhibitorsMyocardial InfarctionAngiotensin-Converting Enzyme Inhibitors030204 cardiovascular system & hematologyACE inhibitor therapyBiochemistryRenin-Angiotensin SystemAnginachemistry.chemical_compoundEndocrinologyMathematical and Statistical Techniques0302 clinical medicineReninMedicine and Health SciencesSecondary Prevention030212 general & internal medicineMyocardial infarctionDiureticsStrokePharmaceuticsRDrugsEnzyme inhibitorsCardiovascular therapyGeneral Medicine3. Good healthHospitalizationStrokeNephrologyCardiovascular DiseasesPhysical SciencesCardiologyMedicineDrug therapyStatistics (Mathematics)Research Articlemedicine.drugAdultmedicine.medical_specialtyEndocrine DisordersCardiologyResearch and Analysis MethodsAngina PectorisDiabetes ComplicationsAngiotensin Receptor Antagonists03 medical and health sciencesDiabetes mellitusInternal medicineRenal DiseasesDiabetes MellitusmedicineHumansStatistical MethodsRenal Insufficiency ChronicPharmacologyHeart FailureCreatinineBiology and life sciencesbusiness.industryOdds ratiomedicine.diseasechemistryMetabolic DisordersHeart failuresistema cardiovascularACE inhibitorEnzymologyKidney Failure ChronicbusinessMathematicsMeta-AnalysisPLOS Medicine
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Coronavirus Disease 2019–Associated Coagulopathy

2021

Patients with the severe form of coronavirus disease 2019 (COVID-19) have been frequently found to suffer from both arterial and venous thrombotic events due to the perpetuation of a hypercoagulable state. This phenomenon, termed COVID-19-associated coagulopathy (CC), is now considered a major component of the pathophysiology of this novel infectious disease, leading to widespread thrombosis. While at first, the vascular insults may be limited to the pulmonary microvasculature, as the disease progresses, systemic involvement occurs, culminating in distant organ thrombosis and multi-organ dysfunction syndrome. In this review article, we discuss recent insights into the pathophysiologic mecha…

ARDSPAI-1 Plasminogen Activator Inhibitor 1VTE venous thromboembolismDiseaseReview030204 cardiovascular system & hematologyCoronavirus Disease 20190302 clinical medicineCoagulopathy030212 general & internal medicineDIC disseminated intravascular coagulationDisseminated intravascular coagulationCOVID-19 Coronavirus disease 2019DVT deep vein thrombosisGeneral MedicineBlood Coagulation DisordersThrombosisICU intensive care unitTMA thrombotic microangiopathyDisease ProgressionCoronavirus Disease 2019 COVID-19 CoagulopathyVWF von Willebrand factormedicine.medical_specialtyThrombotic microangiopathyACE2 angiotensin-converting enzyme 2SARS-CoV-2 severe acute respiratory syndrome coronavirus 203 medical and health sciencesmedicineCoagulopathyHumansIntensive care medicineLY30 lysis at 30 minutesARDS acute respiratory distress syndromeHemostasisNO nitric oxideCoagulationbusiness.industrySARS-CoV-2COVID-19Thrombosismedicine.diseasetPA tissue plasminogen activatorReview articleIL interleukinCoronavirusVascular DisorderPE pulmonary embolismTF tissue factorbusinessCC COVID-associated coagulopathyMayo Clinic Proceedings
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Random allogeneic blood transfusion in pigs: characterisation of a novel experimental model.

2019

BackgroundOrgan cross-talk describes interactions between a primary affected organ and a secondarily injured remote organ, particularly in lung-brain interactions. A common theory is the systemic distribution of inflammatory mediators that are released by the affected organ and transferred through the bloodstream. The present study characterises the baseline immunogenic effects of a novel experimental model of random allogeneic blood transfusion in pigs designed to analyse the role of the bloodstream in organ cross-talk.MethodsAfter approval of the State and Institutional Animal Care Committee, 20 anesthetized pig were randomized in a donor and an acceptor (eachn = 8): the acceptor animals …

ARDSmedicine.medical_specialtyBlood transfusionEmergency and Critical Caremedicine.medical_treatmentSurgery and Surgical Specialtieslcsh:MedicineInflammation030204 cardiovascular system & hematologyGeneral Biochemistry Genetics and Molecular BiologyPulmonary function testing03 medical and health sciences0302 clinical medicinemedicineExperimental modelAdverse effectRespiratory MedicineCrosstalkLungAnesthesiology and Pain ManagementWhole bloodInflammationLungbusiness.industryTransfusionGeneral Neurosciencelcsh:RBrain030208 emergency & critical care medicineHematologyGeneral Medicinemedicine.diseaseBloodPig modellmedicine.anatomical_structureAnesthesiaARDSHistopathologymedicine.symptomGeneral Agricultural and Biological SciencesbusinessPeerJ
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Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study

2020

Abstract Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence o…

ARDSmedicine.medical_treatment030204 cardiovascular system & hematologyCritical Care and Intensive Care MedicineHyperoxemiaHypoxemialaw.inventionHypoxemia0302 clinical medicinelawFraction of inspired oxygenOxygen therapyPrevalenceMedicineHypoxiaAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapy;Respiratory Distress SyndromeHyperbaric OxygenationAcute respiratory distress syndromeRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidHyperoxemiaIntensive care unitIntensive Care UnitsAnesthesiaArtificialmedicine.symptomHumanArtificial ventilationAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapyIntensive Care UnitHyperoxiaNO03 medical and health sciencesIntensive careSettore MED/41 - ANESTESIOLOGIAHumansInvasive mechanical ventilationMortalitybusiness.industryResearchRespiratory Distress Syndrome Adultlcsh:RC86-88.9medicine.diseaseOxygen therapyRespiration Artificialrespiratory tract diseasesOxygenlnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]030228 respiratory systembusiness
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Angiotensin II dependent cardiac remodeling in the eel Anguilla anguilla involves the NOS/NO system

2017

Angiotensin II (AngII), the principal effector of the Renin-Angiotensin System (RAS), plays an important role in controlling mammalian cardiac morpho-functional remodelling. In the eel Anguilla anguilla, one month administration of AngII improves cardiac performance and influences the expression and localization of molecules which regulate cell growth. To deeper investigate the morpho-functional chronic influences of AngII on the eel heart and the molecular mechanisms involved, freshwater eels (A. anguilla) were intraperitoneally injected for 2 months with AngII (1 nmol g BW-1). Then the isolated hearts were subjected to morphological and western blotting analyses, and nitrite measurements.…

AT(2) receptor; ERK(1-2); Hsp90; Myocardial growth; NOSTRIN0301 basic medicineMAPK/ERK pathwayCancer ResearchPhysiologyClinical Biochemistry030204 cardiovascular system & hematologyBiochemistrychemistry.chemical_compound0302 clinical medicineEnosMyocardial growthReceptorMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Receptors AngiotensinVentricular RemodelingAngiotensin IIHeartNitric oxide synthaseERKmedicine.anatomical_structurecardiovascular systemCollagenmedicine.medical_specialtyEndotheliumHeart VentriclesHsp90BiologyNitric OxideNitric oxide03 medical and health sciencesInternal medicinemedicineAnimalsHSP90 Heat-Shock ProteinsVentricular remodelingAT receptorNitritesERK(1-2)Anguillamedicine.diseasebiology.organism_classificationNOSTRINAngiotensin II030104 developmental biologyEndocrinologychemistryAT(2) receptorbiology.proteinNitric Oxide SynthaseProto-Oncogene Proteins c-akt
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Intraoperative transfusion practices in Europe

2016

PubMed: 26787795

AUSTRIAN BENCHMARKMaleBlood transfusionmedicine.medical_treatment610 Medizinanaemia anesthesia blood transfusion surgery transfusion trigger030204 cardiovascular system & hematologyGUIDELINESsurgeryCohort Studies0302 clinical medicine030202 anesthesiologyMedicine and Health SciencesMedicineProspective StudiesProspective cohort studyddc:610Research Support Non-U.S. Gov'tMiddle AgedHospitalsEuropeFemaleAllogeneic transfusionCohort studymedicine.medical_specialtyTransfusion rateObservational Studyanesthesiablood transfusionELECTIVE SURGERYClinical Practice03 medical and health sciencesJournal Articleanaemia ; anesthesia ; blood transfusion ; surgery ; transfusion triggerHumansBlood TransfusionElective surgeryCHLC ANSIntensive care medicineanaemiatransfusion triggerIntraoperative Carebusiness.industryPREOPERATIVE ANEMIAPATIENT BLOOD MANAGEMENTClinical trialAnesthesiology and Pain MedicineEmergency medicinebusinessPacked red blood cellsREQUIREMENTSBritish journal of anaesthesia
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Hypotensive Hemostasis in Patients Presenting with Ruptured Aortic Aneurysm

2017

Hypotensive hemostasis in aortic rupture has been showed to be feasible and advantageous, especially in trauma patients. To date, there are no randomized studies on hypotensive hemostasis in patients with ruptured abdominal aortic aneurysm (rAAA), but observational studies indicate similar advantages when hypotensive hemostasis is used for endovascular aneurysm repair (EVAR) as in trauma patients. Actually, in EVAR for rAAA, a target systolic blood pressure of 90 mmHg or even lower is considered safe in conscious patients. Fluids should be administrated judiciously with the sole aim of maintaining adequate cardiac output and tissue oxygenation, whereas vasoactive pressors or dilatators may …

Abdominal compartment syndromebusiness.industrymedicine.medical_treatmentHypotensive; Hemostasis; Ruptured; Aortic AneurysmHemodynamics030208 emergency & critical care medicineRuptured Aortic Aneurysm030204 cardiovascular system & hematologyHypotensiveHemostasimedicine.diseaseEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareAbdominal aortic aneurysmRupturedAortic Aneurysm03 medical and health sciences0302 clinical medicineBlood pressureAnesthesiaHemostasiscardiovascular systemmedicinebusinessAortic rupture
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