Search results for "102"

APOBEC4 Enhances the Replication of HIV-1

2016

APOBEC4 (A4) is a member of the AID/APOBEC family of cytidine deaminases. In this study we found a high mRNA expression of A4 in human testis. In contrast, there were only low levels of A4 mRNA detectable in 293T, HeLa, Jurkat or A3.01 cells. Ectopic expression of A4 in HeLa cells resulted in mostly cytoplasmic localization of the protein. To test whether A4 has antiviral activity similar to that of proteins of the APOBEC3 (A3) subfamily, A4 was co-expressed in 293T cells with wild type HIV-1 and HIV-1 luciferase reporter viruses. We found that A4 did not inhibit the replication of HIV-1 but instead enhanced the production of HIV-1 in a dose-dependent manner and seemed to act on the viral L…

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

2021

Antiphospholipid antibodies (aPL), assumed to cause antiphospholipid syndrome (APS), are notorious for their heterogeneity in targeting phospholipids and phospholipid-binding proteins. The persistent presence of Lupus anticoagulant and/or aPL against cardiolipin and/or β2-glycoprotein I have been shown to be independent risk factors for vascular thrombosis and pregnancy morbidity in APS. aPL production is thought to be triggered by–among other factors–viral infections, though infection-associated aPL have mostly been considered non-pathogenic. Recently, the potential pathogenicity of infection-associated aPL has gained momentum since an increasing number of patients infected with Severe Acu…

Seeking the Holy Grail: robust chronologies from archaeology and radiocarbon dating combined

2018

The strengths of formal Bayesian chronological modelling are restated, combining as it does knowledge of the archaeology with the radiocarbon dating of carefully chosen samples of known taphonomy in association with diagnostic material culture. The risks of dating bone samples are reviewed, along with a brief history of the development of approaches to the radiocarbon dating of bone. In reply to Strien (2017), selected topics concerned with the emergence and aftermath of the LBK are discussed, as well as the early Vinča, Ražište and Hinkelstein sequences. The need for rigour in an approach which combines archaeology and radiocarbon dating is underlined.

Poisoning histories in the Italian renaissance: The case of Pico Della Mirandola and Angelo Poliziano.

2018

Giovanni Pico della Mirandola and Angelo Poliziano were two of the most important humanists of the Italian Renaissance. They died suddenly in 1494 and their deaths have been for centuries a subject of debate. The exhumation of their remains offered the opportunity to study the cause of their death through a multidisciplinary research project. Anthropological analyses, together with documentary evidences, radiocarbon dating and ancient DNA analysis supported the identification of the remains attributed to Pico. Macroscopic examination did not reveal paleopathological lesions or signs related to syphilis. Heavy metals analysis, carried out on bones and mummified tissues, showed that in Pico's…

Some notes on a second-order random boundary value problem

2017

We consider a two-point boundary value problem of second-order random differential equation. Using a variant of the α-ψ-contractive type mapping theorem in metric spaces, we show the existence of at least one solution.

Structure of eigenvectors of random regular digraphs

2018

Let $d$ and $n$ be integers satisfying $C\leq d\leq \exp(c\sqrt{\ln n})$ for some universal constants $c, C>0$, and let $z\in \mathbb{C}$. Denote by $M$ the adjacency matrix of a random $d$-regular directed graph on $n$ vertices. In this paper, we study the structure of the kernel of submatrices of $M-z\,{\rm Id}$, formed by removing a subset of rows. We show that with large probability the kernel consists of two non-intersecting types of vectors, which we call very steep and gradual with many levels. As a corollary, we show, in particular, that every eigenvector of $M$, except for constant multiples of $(1,1,\dots,1)$, possesses a weak delocalization property: its level sets have cardin…

Fields of values of odd-degree irreducible characters

2019

Abstract In this paper we clarify the quadratic irrationalities that can be admitted by an odd-degree complex irreducible character χ of an arbitrary finite group. Write Q ( χ ) to denote the field generated over the rational numbers by the values of χ, and let d > 1 be a square-free integer. We prove that if Q ( χ ) = Q ( d ) then d ≡ 1 (mod 4) and if Q ( χ ) = Q ( − d ) , then d ≡ 3 (mod 4). This follows from the main result of this paper: either i ∈ Q ( χ ) or Q ( χ ) ⊆ Q ( exp ⁡ ( 2 π i / m ) ) for some odd integer m ≥ 1 .

Free differential Galois groups

2019

We study the structure of the absolute differential Galois group of a rational function field over an algebraically closed field of characteristic zero. In particular, we relate the behavior of differential embedding problems to the condition that the absolute differential Galois group is free as a proalgebraic group. Building on this, we prove Matzat's freeness conjecture in the case that the field of constants is algebraically closed of countably infinite transcendence degree over the rationals. This is the first known case of the twenty year old conjecture.

Cre-lox: Target Sensitivity Matters

2019

Approximation of Baskakov type Pólya–Durrmeyer operators

2017

In the present paper we propose the Durrmeyer type modification of Baskakov operators based on inverse Polya-Eggenberger distribution. First we estimate a recurrence relation by using hypergeometric series. We give a global approximation theorem in terms of second order modulus of continuity, a direct approximation theorem by means of the Ditzian-Totik modulus of smoothness and a Voronovskaja type theorem. Some approximation results in weighted space are obtained. Also, we show the rate of convergence of these operators to certain functions by illustrative graphics using the Maple algorithms.